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182 related items for PubMed ID: 22982239

  • 1. A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.
    Jetzt AE, Cheng JS, Li XP, Tumer NE, Cohick WS.
    Int J Biochem Cell Biol; 2012 Dec; 44(12):2204-11. PubMed ID: 22982239
    [Abstract] [Full Text] [Related]

  • 2. Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells.
    Jetzt AE, Cheng JS, Tumer NE, Cohick WS.
    Int J Biochem Cell Biol; 2009 Dec; 41(12):2503-10. PubMed ID: 19695342
    [Abstract] [Full Text] [Related]

  • 3. Ribosome depurination by ricin leads to inhibition of endoplasmic reticulum stress-induced HAC1 mRNA splicing on the ribosome.
    Pierce M, Vengsarkar D, McLaughlin JE, Kahn JN, Tumer NE.
    J Biol Chem; 2019 Nov 22; 294(47):17848-17862. PubMed ID: 31624149
    [Abstract] [Full Text] [Related]

  • 4. Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.
    Jetzt AE, Li XP, Tumer NE, Cohick WS.
    Toxicol Appl Pharmacol; 2016 Nov 01; 310():120-128. PubMed ID: 27639428
    [Abstract] [Full Text] [Related]

  • 5. Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.
    Li XP, Baricevic M, Saidasan H, Tumer NE.
    Infect Immun; 2007 Jan 01; 75(1):417-28. PubMed ID: 17101666
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  • 9. Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.
    Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.
    J Biol Chem; 2013 Oct 18; 288(42):30270-30284. PubMed ID: 24003229
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  • 10. Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding.
    Li XP, Kahn JN, Tumer NE.
    Toxins (Basel); 2018 Sep 13; 10(9):. PubMed ID: 30217009
    [Abstract] [Full Text] [Related]

  • 11. Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.
    Pierce M, Kahn JN, Chiou J, Tumer NE.
    RNA; 2011 Jan 13; 17(1):201-10. PubMed ID: 21098653
    [Abstract] [Full Text] [Related]

  • 12. Identification of small molecules that suppress ricin-induced stress-activated signaling pathways.
    Wahome PG, Ahlawat S, Mantis NJ.
    PLoS One; 2012 Jan 13; 7(11):e49075. PubMed ID: 23133670
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  • 13. The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.
    Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.
    Mol Microbiol; 2008 Dec 13; 70(6):1441-52. PubMed ID: 19019145
    [Abstract] [Full Text] [Related]

  • 14. The action of pokeweed antiviral protein and ricin A-chain on mutants in the alpha-sarcin loop of Escherichia coli 23S ribosomal RNA.
    Marchant A, Hartley MR.
    J Mol Biol; 1995 Dec 15; 254(5):848-55. PubMed ID: 7500355
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  • 15. Expression of novel fusion antiviral proteins ricin a chain-pokeweed antiviral proteins (RTA-PAPs) in Escherichia coli and their inhibition of protein synthesis and of hepatitis B virus in vitro.
    Hassan Y, Ogg S, Ge H.
    BMC Biotechnol; 2018 Aug 06; 18(1):47. PubMed ID: 30081895
    [Abstract] [Full Text] [Related]

  • 16. Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes.
    Gould JH, Hartley MR, Welsh PC, Hoshizaki DK, Frankel A, Roberts LM, Lord JM.
    Mol Gen Genet; 1991 Nov 06; 230(1-2):81-90. PubMed ID: 1745246
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  • 17. Targeting ricin to the ribosome.
    May KL, Yan Q, Tumer NE.
    Toxicon; 2013 Jul 06; 69():143-51. PubMed ID: 23454625
    [Abstract] [Full Text] [Related]

  • 18. Adapting yeast as model to study ricin toxin a uptake and trafficking.
    Becker B, Schmitt MJ.
    Toxins (Basel); 2011 Jul 06; 3(7):834-47. PubMed ID: 22069743
    [Abstract] [Full Text] [Related]

  • 19. Leucine 232 and hydrophobic residues at the ribosomal P stalk binding site are critical for biological activity of ricin.
    Zhou Y, Li XP, Kahn JN, McLaughlin JE, Tumer NE.
    Biosci Rep; 2019 Oct 30; 39(10):. PubMed ID: 31548364
    [Abstract] [Full Text] [Related]

  • 20. Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.
    Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE.
    J Biol Chem; 2010 Dec 31; 285(53):41463-71. PubMed ID: 20974854
    [Abstract] [Full Text] [Related]

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