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710 related items for PubMed ID: 22982773

  • 1. A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.
    Maxwell DM, Brecht KM, Sweeney RE.
    Chem Biol Interact; 2013 Mar 25; 203(1):72-6. PubMed ID: 22982773
    [Abstract] [Full Text] [Related]

  • 2. Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
    Worek F, Herkert NM, Koller M, Aurbek N, Thiermann H.
    Toxicol Lett; 2009 Jun 01; 187(2):119-23. PubMed ID: 19429253
    [Abstract] [Full Text] [Related]

  • 3. Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
    Aurbek N, Herkert NM, Koller M, Thiermann H, Worek F.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):215-9. PubMed ID: 20105433
    [Abstract] [Full Text] [Related]

  • 4. Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
    Worek F, Aurbek N, Koller M, Becker C, Eyer P, Thiermann H.
    Biochem Pharmacol; 2007 Jun 01; 73(11):1807-17. PubMed ID: 17382909
    [Abstract] [Full Text] [Related]

  • 5. Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
    Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H.
    Arch Toxicol; 2012 Sep 01; 86(9):1379-86. PubMed ID: 22437842
    [Abstract] [Full Text] [Related]

  • 6. Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.
    Luo C, Saxena A, Smith M, Garcia G, Radić Z, Taylor P, Doctor BP.
    Biochemistry; 1999 Aug 03; 38(31):9937-47. PubMed ID: 10433700
    [Abstract] [Full Text] [Related]

  • 7. Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
    Bartling A, Worek F, Szinicz L, Thiermann H.
    Toxicology; 2007 Apr 20; 233(1-3):166-72. PubMed ID: 16904809
    [Abstract] [Full Text] [Related]

  • 8. Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
    Renou J, Mercey G, Verdelet T, Păunescu E, Gillon E, Arboléas M, Loiodice M, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY.
    Chem Biol Interact; 2013 Mar 25; 203(1):81-4. PubMed ID: 23111374
    [Abstract] [Full Text] [Related]

  • 9. Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.
    Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F.
    Toxicol Lett; 2016 Feb 26; 244():136-142. PubMed ID: 26210933
    [Abstract] [Full Text] [Related]

  • 10. Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.
    Worek F, Aurbek N, Thiermann H.
    J Appl Toxicol; 2007 Feb 26; 27(6):582-8. PubMed ID: 17370251
    [Abstract] [Full Text] [Related]

  • 11. Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.
    Horn G, de Koning MC, van Grol M, Thiermann H, Worek F.
    Toxicol Lett; 2018 Dec 15; 299():218-225. PubMed ID: 30312685
    [Abstract] [Full Text] [Related]

  • 12. Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.
    Scheffel C, Thiermann H, Worek F.
    Toxicol Lett; 2015 Feb 03; 232(3):557-65. PubMed ID: 25522658
    [Abstract] [Full Text] [Related]

  • 13. Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
    Worek F, Wille T, Koller M, Thiermann H.
    Chem Biol Interact; 2013 Mar 25; 203(1):125-8. PubMed ID: 22827894
    [Abstract] [Full Text] [Related]

  • 14. A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
    Kuca K, Cabal J, Kassa J.
    Pharmazie; 2004 Oct 25; 59(10):795-8. PubMed ID: 15544060
    [Abstract] [Full Text] [Related]

  • 15. A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
    Bajgar J, Hajek P, Zdarova JK, Kassa J, Paseka A, Slizova D, Krs O, Kuca K, Jun D, Fusek J, Capek L.
    J Enzyme Inhib Med Chem; 2010 Dec 25; 25(6):790-7. PubMed ID: 21054236
    [Abstract] [Full Text] [Related]

  • 16. In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers.
    Acharya J, Dubey DK, Srivastava AK, Raza SK.
    Toxicol In Vitro; 2011 Feb 25; 25(1):251-6. PubMed ID: 20688148
    [Abstract] [Full Text] [Related]

  • 17. Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
    Kuca K, Jun D.
    J Med Toxicol; 2006 Dec 25; 2(4):141-6. PubMed ID: 18072133
    [Abstract] [Full Text] [Related]

  • 18. Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.
    Esposito EX, Stouch TR, Wymore T, Madura JD.
    Chem Res Toxicol; 2014 Jan 21; 27(1):99-110. PubMed ID: 24443939
    [Abstract] [Full Text] [Related]

  • 19. A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Maxwell DM, Koplovitz I, Worek F, Sweeney RE.
    Toxicol Appl Pharmacol; 2008 Sep 01; 231(2):157-64. PubMed ID: 18508103
    [Abstract] [Full Text] [Related]

  • 20. Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
    Worek F, Koller M, Thiermann H, Wille T.
    Toxicology; 2016 Mar 28; 350-352():25-30. PubMed ID: 27153754
    [Abstract] [Full Text] [Related]

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