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433 related items for PubMed ID: 22984888

  • 1. Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.
    Aryapour H, Riazi GH, Ahmadian S, Foroumadi A, Mahdavi M, Emami S.
    Pharm Biol; 2012 Dec; 50(12):1551-60. PubMed ID: 22984888
    [Abstract] [Full Text] [Related]

  • 2. Development of a novel class of tubulin inhibitors with promising anticancer activities.
    Xi J, Zhu X, Feng Y, Huang N, Luo G, Mao Y, Han X, Tian W, Wang G, Han X, Luo R, Huang Z, An J.
    Mol Cancer Res; 2013 Aug; 11(8):856-64. PubMed ID: 23666368
    [Abstract] [Full Text] [Related]

  • 3. Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.
    Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.
    J Med Chem; 2014 Aug 14; 57(15):6364-82. PubMed ID: 25061803
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.
    Dyrager C, Wickström M, Fridén-Saxin M, Friberg A, Dahlén K, Wallén EA, Gullbo J, Grøtli M, Luthman K.
    Bioorg Med Chem; 2011 Apr 15; 19(8):2659-65. PubMed ID: 21459004
    [Abstract] [Full Text] [Related]

  • 5. Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
    Ducki S, Rennison D, Woo M, Kendall A, Chabert JF, McGown AT, Lawrence NJ.
    Bioorg Med Chem; 2009 Nov 15; 17(22):7698-710. PubMed ID: 19837593
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
    Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E.
    Bioorg Med Chem; 2008 May 15; 16(10):5367-76. PubMed ID: 18440234
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.
    Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.
    Bioorg Med Chem; 2012 Nov 01; 20(21):6285-95. PubMed ID: 23022053
    [Abstract] [Full Text] [Related]

  • 8. Brine shrimp lethality assay 'an effective prescreen': microwave-assisted synthesis, BSL toxicity and 3DQSAR studies-based designing, docking and antitumor evaluation of potent chalcones.
    Nazir S, Ansari FL, Hussain T, Mazhar K, Muazzam AG, Qasmi ZU, Makhmoor T, Noureen H, Mirza B.
    Pharm Biol; 2013 Sep 01; 51(9):1091-103. PubMed ID: 23745524
    [Abstract] [Full Text] [Related]

  • 9. Cytotoxic activity and cytostatic mechanism of novel 2-arylbenzo[b]furans.
    Yang H, Pang JY, Cai YC, Xu ZL, Xian LJ.
    J Pharm Pharmacol; 2006 Sep 01; 58(9):1281-7. PubMed ID: 16945188
    [Abstract] [Full Text] [Related]

  • 10. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system.
    Sengupta S, Smitha SL, Thomas NE, Santhoshkumar TR, Devi SK, Sreejalekshmi KG, Rajasekharan KN.
    Br J Pharmacol; 2005 Aug 01; 145(8):1076-83. PubMed ID: 15951833
    [Abstract] [Full Text] [Related]

  • 11. DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080.
    Qiao F, Zuo D, Shen X, Qi H, Wang H, Zhang W, Wu Y.
    Cancer Chemother Pharmacol; 2012 Aug 01; 70(2):259-70. PubMed ID: 22752214
    [Abstract] [Full Text] [Related]

  • 12. Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones.
    Raffa D, Edler MC, Daidone G, Maggio B, Merikech M, Plescia S, Schillaci D, Bai R, Hamel E.
    Eur J Med Chem; 2004 Apr 01; 39(4):299-304. PubMed ID: 15072839
    [Abstract] [Full Text] [Related]

  • 13. Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.
    Kim ND, Park ES, Kim YH, Moon SK, Lee SS, Ahn SK, Yu DY, No KT, Kim KH.
    Bioorg Med Chem; 2010 Oct 01; 18(19):7092-100. PubMed ID: 20810285
    [Abstract] [Full Text] [Related]

  • 14. A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.
    Yan J, Pang Y, Sheng J, Wang Y, Chen J, Hu J, Huang L, Li X.
    Biochem Pharmacol; 2015 Sep 01; 97(1):51-61. PubMed ID: 26212540
    [Abstract] [Full Text] [Related]

  • 15. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
    Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D.
    Biochemistry; 2004 Jun 01; 43(21):6645-55. PubMed ID: 15157098
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.
    Xu S, An B, Li Y, Luo X, Li X, Jia X.
    Bioorg Med Chem Lett; 2018 Jun 01; 28(10):1769-1775. PubMed ID: 29673981
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents.
    Cao D, Han X, Wang G, Yang Z, Peng F, Ma L, Zhang R, Ye H, Tang M, Wu W, Lei K, Wen J, Chen J, Qiu J, Liang X, Ran Y, Sang Y, Xiang M, Peng A, Chen L.
    Eur J Med Chem; 2013 Apr 01; 62():579-89. PubMed ID: 23425970
    [Abstract] [Full Text] [Related]

  • 18. Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.
    Chang JY, Chang CY, Kuo CC, Chen LT, Wein YS, Kuo YH.
    Mol Pharmacol; 2004 Jan 01; 65(1):77-84. PubMed ID: 14722239
    [Abstract] [Full Text] [Related]

  • 19. 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors.
    Nien CY, Chen YC, Kuo CC, Hsieh HP, Chang CY, Wu JS, Wu SY, Liou JP, Chang JY.
    J Med Chem; 2010 Mar 11; 53(5):2309-13. PubMed ID: 20148562
    [Abstract] [Full Text] [Related]

  • 20. Novel shikonin derivatives targeting tubulin as anticancer agents.
    Guo J, Chen XF, Liu J, Lin HY, Han HW, Liu HC, Huang SC, Shahla BK, Kulek A, Qi JL, Wang XM, Ling LJ, Yang YH.
    Chem Biol Drug Des; 2014 Nov 11; 84(5):603-15. PubMed ID: 24797889
    [Abstract] [Full Text] [Related]

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