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94 related items for PubMed ID: 22985969

  • 1. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
    Hansen RR, Erichsen HK, Brown DT, Mirza NR, Munro G.
    Neuropharmacology; 2012 Dec; 63(8):1360-7. PubMed ID: 22985969
    [Abstract] [Full Text] [Related]

  • 2. A question of balance--positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain.
    Munro G, Erichsen HK, Rae MG, Mirza NR.
    Neuropharmacology; 2011 Dec; 61(1-2):121-32. PubMed ID: 21439986
    [Abstract] [Full Text] [Related]

  • 3. GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.
    de Lucas AG, Ahring PK, Larsen JS, Rivera-Arconada I, Lopez-Garcia JA, Mirza NR, Munro G.
    Biochem Pharmacol; 2015 Feb 01; 93(3):370-9. PubMed ID: 25542996
    [Abstract] [Full Text] [Related]

  • 4. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain.
    Munro G, Lopez-Garcia JA, Rivera-Arconada I, Erichsen HK, Nielsen EØ, Larsen JS, Ahring PK, Mirza NR.
    J Pharmacol Exp Ther; 2008 Dec 01; 327(3):969-81. PubMed ID: 18791060
    [Abstract] [Full Text] [Related]

  • 5. The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
    Munro G, Storm A, Hansen MK, Dyhr H, Marcher L, Erichsen HK, Sheykhzade M.
    Pharmacol Biochem Behav; 2012 May 01; 101(3):465-78. PubMed ID: 22366217
    [Abstract] [Full Text] [Related]

  • 6. CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
    Bassani F, Bergamaschi M, Tonino Bolzoni P, Villetti G.
    Eur J Pharmacol; 2005 Sep 20; 519(3):231-6. PubMed ID: 16125167
    [Abstract] [Full Text] [Related]

  • 7. Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
    Zhu CZ, Mills CD, Hsieh GC, Zhong C, Mikusa J, Lewis LG, Gauvin D, Lee CH, Decker MW, Bannon AW, Rueter LE, Joshi SK.
    Eur J Pain; 2012 Jul 20; 16(6):816-26. PubMed ID: 22337256
    [Abstract] [Full Text] [Related]

  • 8. Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity.
    Joshi SK, Hernandez G, Mikusa JP, Zhu CZ, Zhong C, Salyers A, Wismer CT, Chandran P, Decker MW, Honore P.
    Neuroscience; 2006 Dec 01; 143(2):587-96. PubMed ID: 16962719
    [Abstract] [Full Text] [Related]

  • 9. Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem.
    Vinkers CH, Olivier B, Hanania T, Min W, Schreiber R, Hopkins SC, Campbell U, Paterson N.
    Eur J Pharmacol; 2011 Oct 01; 668(1-2):190-3. PubMed ID: 21762686
    [Abstract] [Full Text] [Related]

  • 10. Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
    Mills CD, Nguyen T, Tanga FY, Zhong C, Gauvin DM, Mikusa J, Gomez EJ, Salyers AK, Bannon AW.
    Eur J Pain; 2013 Apr 01; 17(4):469-79. PubMed ID: 22915527
    [Abstract] [Full Text] [Related]

  • 11. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
    Hofmann M, Kordás KS, Gravius A, Bölcskei K, Parsons CG, Dekundy A, Danysz W, Dézsi L, Wittko-Schneider IM, Sághy K, Gyertyán I, Horváth C.
    Behav Pharmacol; 2012 Dec 01; 23(8):790-801. PubMed ID: 23075708
    [Abstract] [Full Text] [Related]

  • 12. Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
    Suarez-Roca H, Leal L, Silva JA, Pinerua-Shuhaibar L, Quintero L.
    Behav Brain Res; 2008 May 16; 189(1):159-69. PubMed ID: 18255166
    [Abstract] [Full Text] [Related]

  • 13. Reversal of pathological pain through specific spinal GABAA receptor subtypes.
    Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU.
    Nature; 2008 Jan 17; 451(7176):330-4. PubMed ID: 18202657
    [Abstract] [Full Text] [Related]

  • 14. Comparative effects of nonselective and subtype-selective gamma-aminobutyric acidA receptor positive modulators in the rat-conditioned emotional response test.
    Mathiasen LS, Rodgers RJ, Mirza NR.
    Behav Pharmacol; 2007 May 17; 18(3):191-203. PubMed ID: 17426483
    [Abstract] [Full Text] [Related]

  • 15. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy.
    Mirza NR, Larsen JS, Mathiasen C, Jacobsen TA, Munro G, Erichsen HK, Nielsen AN, Troelsen KB, Nielsen EØ, Ahring PK.
    J Pharmacol Exp Ther; 2008 Dec 17; 327(3):954-68. PubMed ID: 18791063
    [Abstract] [Full Text] [Related]

  • 16. The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.
    Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, Yang L, Guo W, Golani LK, Anderson WH, Catlow JT, Jones TM, Porreca F, Smith JL, Knopp KL, Cook JM.
    Pharmacol Biochem Behav; 2019 May 17; 180():22-31. PubMed ID: 30825491
    [Abstract] [Full Text] [Related]

  • 17. Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
    Urban MO, Ren K, Park KT, Campbell B, Anker N, Stearns B, Aiyar J, Belley M, Cohen C, Bristow L.
    J Pharmacol Exp Ther; 2005 Jun 17; 313(3):1209-16. PubMed ID: 15734900
    [Abstract] [Full Text] [Related]

  • 18. Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms.
    Gannon RL, Millan MJ.
    Pharmacol Biochem Behav; 2011 Oct 17; 99(4):712-7. PubMed ID: 21756929
    [Abstract] [Full Text] [Related]

  • 19. TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
    Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM.
    J Pharmacol Exp Ther; 2006 Jan 17; 316(1):410-22. PubMed ID: 16183706
    [Abstract] [Full Text] [Related]

  • 20. Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
    Anseloni VC, Gold MS.
    J Pain; 2008 Aug 17; 9(8):732-8. PubMed ID: 18467182
    [Abstract] [Full Text] [Related]

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