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Journal Abstract Search

216 related items for PubMed ID: 22986013

  • 1. A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans.
    Wolf B, Morgan H, Krieg J, Gani Z, Milicov A, Warncke M, Brennan F, Jones S, Sims J, Kiessling A.
    Cytokine; 2012 Dec; 60(3):828-37. PubMed ID: 22986013
    [Abstract] [Full Text] [Related]

  • 2. A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.
    Dhir V, Fort M, Mahmood A, Higbee R, Warren W, Narayanan P, Wittman V.
    J Immunotoxicol; 2012 Dec; 9(1):34-42. PubMed ID: 22074378
    [Abstract] [Full Text] [Related]

  • 3. Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis.
    Walker MR, Makropoulos DA, Achuthanandam R, Van Arsdell S, Bugelski PJ.
    Int Immunopharmacol; 2011 Nov; 11(11):1697-705. PubMed ID: 21689786
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  • 4. A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies.
    Bailey L, Moreno L, Manigold T, Krasniqi S, Kropshofer H, Hinton H, Singer T, Suter L, Hansel TT, Mitchell JA.
    J Pharmacol Toxicol Methods; 2013 Nov; 68(2):231-239. PubMed ID: 23280407
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  • 5. Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?
    Iwata Y, Harada A, Hara T, Kubo C, Inoue T, Tabo M, Ploix C, Manigold T, Hinton H, Mishima M.
    J Toxicol Sci; 2016 Nov; 41(4):523-31. PubMed ID: 27432238
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  • 6. Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.
    Findlay L, Sharp G, Fox B, Ball C, Robinson CJ, Bird C, Stebbings R, Eastwood D, Wadhwa M, Poole S, Thorpe R, Thorpe SJ.
    Cytokine; 2011 Jul; 55(1):141-51. PubMed ID: 21493088
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  • 7. Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.
    Vessillier S, Eastwood D, Fox B, Sathish J, Sethu S, Dougall T, Thorpe SJ, Thorpe R, Stebbings R.
    J Immunol Methods; 2015 Sep; 424():43-52. PubMed ID: 25960173
    [Abstract] [Full Text] [Related]

  • 8. Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog.
    Iwata Y, Harada A, Kubo C, Inoue T, Tabo M, Mishima M.
    Biochem Biophys Res Commun; 2018 Jul 07; 502(1):91-97. PubMed ID: 29787754
    [Abstract] [Full Text] [Related]

  • 9. Antibody C region influences TGN1412-like functional activity in vitro.
    Ball C, Fox B, Hufton S, Sharp G, Poole S, Stebbings R, Eastwood D, Findlay L, Parren PW, Thorpe R, Bristow A, Thorpe SJ.
    J Immunol; 2012 Dec 15; 189(12):5831-40. PubMed ID: 23150712
    [Abstract] [Full Text] [Related]

  • 10. Development of the first reference antibody panel for qualification and validation of cytokine release assay platforms - Report of an international collaborative study.
    Vessillier S, Fort M, O'Donnell L, Hinton H, Nadwodny K, Piccotti J, Rigsby P, Staflin K, Stebbings R, Mekala D, Willingham A, Wolf B, participants of the study.
    Cytokine X; 2020 Dec 15; 2(4):100042. PubMed ID: 33458650
    [Abstract] [Full Text] [Related]

  • 11. Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.
    Tabares P, Berr S, Römer PS, Chuvpilo S, Matskevich AA, Tyrsin D, Fedotov Y, Einsele H, Tony HP, Hünig T.
    Eur J Immunol; 2014 Apr 15; 44(4):1225-36. PubMed ID: 24374661
    [Abstract] [Full Text] [Related]

  • 12. TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model.
    Weißmüller S, Kronhart S, Kreuz D, Schnierle B, Kalinke U, Kirberg J, Hanschmann KM, Waibler Z.
    PLoS One; 2016 Apr 15; 11(3):e0149093. PubMed ID: 26959227
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  • 14. Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics.
    Fletcher EAK, Eltahir M, Lindqvist F, Rieth J, Törnqvist G, Leja-Jarblad J, Mangsbo SM.
    Int Immunopharmacol; 2018 Jan 15; 54():1-11. PubMed ID: 29100032
    [Abstract] [Full Text] [Related]

  • 15. Cytokine release assays: current practices and future directions.
    Finco D, Grimaldi C, Fort M, Walker M, Kiessling A, Wolf B, Salcedo T, Faggioni R, Schneider A, Ibraghimov A, Scesney S, Serna D, Prell R, Stebbings R, Narayanan PK.
    Cytokine; 2014 Apr 15; 66(2):143-55. PubMed ID: 24412476
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  • 17. FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells.
    Sakuma S, Kato Y, Nishigaki F, Sasakawa T, Magari K, Miyata S, Ohkubo Y, Goto T.
    Br J Pharmacol; 2000 Aug 15; 130(7):1655-63. PubMed ID: 10928971
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