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Journal Abstract Search

859 related items for PubMed ID: 22993429

  • 1. Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
    Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.
    J Neurosci; 2012 Sep 19; 32(38):13125-36. PubMed ID: 22993429
    [Abstract] [Full Text] [Related]

  • 2. Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.
    Carter AY, Letronne F, Fitz NF, Mounier A, Wolfe CM, Nam KN, Reeves VL, Kamboh H, Lefterov I, Koldamova R.
    PLoS One; 2017 Sep 19; 12(2):e0172161. PubMed ID: 28241068
    [Abstract] [Full Text] [Related]

  • 3. Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
    Fitz NF, Wolfe CM, Playso BE, Biedrzycki RJ, Lu Y, Nam KN, Lefterov I, Koldamova R.
    Mol Neurodegener; 2020 Jul 23; 15(1):41. PubMed ID: 32703241
    [Abstract] [Full Text] [Related]

  • 4. A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3.
    Valencia-Olvera AC, Balu D, Bellur S, McNally T, Saleh Y, Pham D, Ghura S, York J, Johansson JO, LaDu MJ, Tai L.
    Alzheimers Res Ther; 2023 Dec 15; 15(1):216. PubMed ID: 38102668
    [Abstract] [Full Text] [Related]

  • 5. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
    Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L.
    J Neurosci; 2002 Dec 15; 22(24):10539-48. PubMed ID: 12486146
    [Abstract] [Full Text] [Related]

  • 6. Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.
    Boehm-Cagan A, Bar R, Harats D, Shaish A, Levkovitz H, Bielicki JK, Johansson JO, Michaelson DM.
    PLoS One; 2016 Dec 15; 11(11):e0166195. PubMed ID: 27824936
    [Abstract] [Full Text] [Related]

  • 7. Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.
    Fitz NF, Tapias V, Cronican AA, Castranio EL, Saleem M, Carter AY, Lefterova M, Lefterov I, Koldamova R.
    Brain; 2015 Dec 15; 138(Pt 12):3699-715. PubMed ID: 26510953
    [Abstract] [Full Text] [Related]

  • 8. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
    Honda K, Saito Y, Saito H, Toyoda M, Abe R, Saito T, Saido TC, Michikawa M, Taru H, Sobu Y, Hata S, Nakaya T, Suzuki T.
    Neurobiol Aging; 2023 Mar 15; 123():63-74. PubMed ID: 36638682
    [Abstract] [Full Text] [Related]

  • 9. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.
    Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM.
    J Neurosci; 2005 Mar 16; 25(11):2803-10. PubMed ID: 15772340
    [Abstract] [Full Text] [Related]

  • 10. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
    Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T.
    J Neurosci; 2016 Mar 30; 36(13):3848-59. PubMed ID: 27030769
    [Abstract] [Full Text] [Related]

  • 11. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.
    Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM.
    Acta Neuropathol Commun; 2015 Nov 10; 3():70. PubMed ID: 26556230
    [Abstract] [Full Text] [Related]

  • 12. Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.
    Boehm-Cagan A, Michaelson DM.
    J Neurosci; 2014 May 21; 34(21):7293-301. PubMed ID: 24849361
    [Abstract] [Full Text] [Related]

  • 13. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease.
    Fitz NF, Nam KN, Wolfe CM, Letronne F, Playso BE, Iordanova BE, Kozai TDY, Biedrzycki RJ, Kagan VE, Tyurina YY, Han X, Lefterov I, Koldamova R.
    Nat Commun; 2021 Jun 07; 12(1):3416. PubMed ID: 34099706
    [Abstract] [Full Text] [Related]

  • 14. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.
    Jansen PJ, Lütjohann D, Thelen KM, von Bergmann K, van Leuven F, Ramaekers FC, Monique M.
    J Alzheimers Dis; 2009 Jun 07; 18(2):319-29. PubMed ID: 19584433
    [Abstract] [Full Text] [Related]

  • 15. Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.
    Lattanzio F, Carboni L, Carretta D, Rimondini R, Candeletti S, Romualdi P.
    Neuroscience; 2014 Jan 03; 256():360-9. PubMed ID: 24161275
    [Abstract] [Full Text] [Related]

  • 16. Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4.
    Velma GR, Laham MS, Lewandowski C, Valencia-Olvera AC, Balu D, Moore A, Ackerman-Berrier M, Rychetsky P, Penton C, Musku SR, Annadurai A, Sulaiman MI, Ma N, J Thatcher GR.
    J Med Chem; 2024 Sep 12; 67(17):15061-15079. PubMed ID: 39191400
    [Abstract] [Full Text] [Related]

  • 17. ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
    Fitz NF, Carter AY, Tapias V, Castranio EL, Kodali R, Lefterov I, Koldamova R.
    J Alzheimers Dis; 2017 Sep 12; 56(3):1075-1085. PubMed ID: 28106559
    [Abstract] [Full Text] [Related]

  • 18. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.
    Pankiewicz JE, Guridi M, Kim J, Asuni AA, Sanchez S, Sullivan PM, Holtzman DM, Sadowski MJ.
    Acta Neuropathol Commun; 2014 Jun 28; 2():75. PubMed ID: 24972680
    [Abstract] [Full Text] [Related]

  • 19. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1.
    Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T.
    J Clin Invest; 2019 Mar 01; 129(3):1272-1277. PubMed ID: 30741718
    [Abstract] [Full Text] [Related]

  • 20. APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice.
    Kunzler J, Youmans KL, Yu C, Ladu MJ, Tai LM.
    Neurosci Lett; 2014 Feb 07; 560():131-6. PubMed ID: 24368217
    [Abstract] [Full Text] [Related]

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