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Journal Abstract Search

160 related items for PubMed ID: 23010268

  • 1. Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
    Sund C, Belda O, Borkakoti N, Lindberg J, Derbyshire D, Vrang L, Hamelink E, Åhgren C, Woestenenk E, Wikström K, Eneroth A, Lindström E, Kalayanov G.
    Bioorg Med Chem Lett; 2012 Nov 01; 22(21):6721-7. PubMed ID: 23010268
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  • 4. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
    Probst GD, Bowers S, Sealy JM, Stupi B, Dressen D, Jagodzinska BM, Aquino J, Gailunas A, Truong AP, Tso L, Xu YZ, Hom RK, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Sham HL, Jagodzinski J, Toth G, Brecht E, Yao N, Pan H, Lin M, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Gauby S, Zmolek W, Quinn KP, Sauer JM.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6034-9. PubMed ID: 20822903
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  • 11. Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
    Choi SJ, Cho JH, Im I, Lee SD, Jang JY, Oh YM, Jung YK, Jeon ES, Kim YC.
    Eur J Med Chem; 2010 Jun 15; 45(6):2578-90. PubMed ID: 20303626
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  • 12. Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
    Truong AP, Tóth G, Probst GD, Sealy JM, Bowers S, Wone DW, Dressen D, Hom RK, Konradi AW, Sham HL, Wu J, Peterson BT, Ruslim L, Bova MP, Kholodenko D, Motter RN, Bard F, Santiago P, Ni H, Chian D, Soriano F, Cole T, Brigham EF, Wong K, Zmolek W, Goldbach E, Samant B, Chen L, Zhang H, Nakamura DF, Quinn KP, Yednock TA, Sauer JM.
    Bioorg Med Chem Lett; 2010 Nov 01; 20(21):6231-6. PubMed ID: 20833041
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  • 17. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
    Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF.
    J Med Chem; 2010 Feb 11; 53(3):942-50. PubMed ID: 20043700
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  • 18. Design, synthesis and docking studies of Hydroxyethylamine and Hydroxyethylsulfide BACE-1 inhibitors.
    Rizzi L, Vaiana N, Sagui F, Genesio E, Pilli E, Porcari V, Romeo S.
    Protein Pept Lett; 2009 Feb 11; 16(1):86-90. PubMed ID: 19149679
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  • 19. Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives.
    Park H, Min K, Kwak HS, Koo KD, Lim D, Seo SW, Choi JU, Platt B, Choi DY.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2900-4. PubMed ID: 18434152
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  • 20. BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
    Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4639-44. PubMed ID: 20579874
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