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Journal Abstract Search

153 related items for PubMed ID: 23025997

  • 1. Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR).
    Zinglé C, Kuntz L, Tritsch D, Grosdemange-Billiard C, Rohmer M.
    Bioorg Med Chem Lett; 2012 Nov 01; 22(21):6563-7. PubMed ID: 23025997
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  • 5. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L, de Andrés-Gómez A, Dick B, Cox RJ, Godfrey CR.
    Chembiochem; 2005 Oct 01; 6(10):1866-74. PubMed ID: 16116659
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  • 9. Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
    Andaloussi M, Lindh M, Björkelid C, Suresh S, Wieckowska A, Iyer H, Karlén A, Larhed M.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5403-7. PubMed ID: 21824775
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  • 10. Synthesis and biological evaluation of phosphate isosters of fosmidomycin and analogs as inhibitors of Escherichia coli and Mycobacterium smegmatis 1-deoxyxylulose 5-phosphate reductoisomerases.
    Munier M, Tritsch D, Krebs F, Esque J, Hemmerlin A, Rohmer M, Stote RH, Grosdemange-Billiard C.
    Bioorg Med Chem; 2017 Jan 15; 25(2):684-689. PubMed ID: 27955925
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  • 11. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A, Lange R, Fernandes RP, Schulz H, Dale GE, Douangamath A, Proteau PJ, Oefner C.
    J Mol Biol; 2005 Jan 07; 345(1):115-27. PubMed ID: 15567415
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  • 13. Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S.
    J Med Chem; 2015 Apr 09; 58(7):2988-3001. PubMed ID: 25781377
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  • 14. Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
    Kuntz L, Tritsch D, Grosdemange-Billiard C, Hemmerlin A, Willem A, Bach TJ, Rohmer M.
    Biochem J; 2005 Feb 15; 386(Pt 1):127-35. PubMed ID: 15473867
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  • 15. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
    Humnabadkar V, Jha RK, Ghatnekar N, De Sousa SM.
    J Biomol Screen; 2011 Mar 15; 16(3):303-12. PubMed ID: 21335601
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  • 19. α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.
    Brücher K, Illarionov B, Held J, Tschan S, Kunfermann A, Pein MK, Bacher A, Gräwert T, Maes L, Mordmüller B, Fischer M, Kurz T.
    J Med Chem; 2012 Jul 26; 55(14):6566-75. PubMed ID: 22731758
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  • 20. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
    Ortmann R, Wiesner J, Silber K, Klebe G, Jomaa H, Schlitzer M.
    Arch Pharm (Weinheim); 2007 Sep 26; 340(9):483-90. PubMed ID: 17806130
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