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Journal Abstract Search

333 related items for PubMed ID: 23030823

  • 1. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
    Najafov A, Shpiro N, Alessi DR.
    Biochem J; 2012 Dec 01; 448(2):285-95. PubMed ID: 23030823
    [Abstract] [Full Text] [Related]

  • 2. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
    Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR.
    Biochem J; 2011 Jan 15; 433(2):357-69. PubMed ID: 21087210
    [Abstract] [Full Text] [Related]

  • 3. PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway.
    Zhang X, Zhong S.
    Anticancer Agents Med Chem; 2020 Jan 15; 20(7):828-833. PubMed ID: 32188393
    [Abstract] [Full Text] [Related]

  • 4. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
    Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.
    J Biol Chem; 1999 Dec 24; 274(52):37400-6. PubMed ID: 10601311
    [Abstract] [Full Text] [Related]

  • 5. Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
    Soares HP, Ming M, Mellon M, Young SH, Han L, Sinnet-Smith J, Rozengurt E.
    Mol Cancer Ther; 2015 Apr 24; 14(4):1014-23. PubMed ID: 25673820
    [Abstract] [Full Text] [Related]

  • 6. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
    McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR.
    EMBO J; 2004 May 19; 23(10):2071-82. PubMed ID: 15116068
    [Abstract] [Full Text] [Related]

  • 7. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
    Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W.
    Cancer Discov; 2015 Nov 19; 5(11):1194-209. PubMed ID: 26293922
    [Abstract] [Full Text] [Related]

  • 8. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
    Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR.
    Curr Biol; 1999 Apr 22; 9(8):393-404. PubMed ID: 10226025
    [Abstract] [Full Text] [Related]

  • 9. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.
    Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR.
    EMBO J; 2001 Aug 15; 20(16):4380-90. PubMed ID: 11500365
    [Abstract] [Full Text] [Related]

  • 10. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
    Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR.
    Biochem J; 2014 Nov 01; 463(3):413-27. PubMed ID: 25177796
    [Abstract] [Full Text] [Related]

  • 11. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
    Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB.
    PLoS One; 2010 Mar 26; 5(3):e9910. PubMed ID: 20361045
    [Abstract] [Full Text] [Related]

  • 12. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
    García-Martínez JM, Alessi DR.
    Biochem J; 2008 Dec 15; 416(3):375-85. PubMed ID: 18925875
    [Abstract] [Full Text] [Related]

  • 13. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
    Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.
    J Cell Sci; 2005 Nov 01; 118(Pt 21):5023-34. PubMed ID: 16219676
    [Abstract] [Full Text] [Related]

  • 14. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
    Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S.
    Hepatology; 2009 Jan 01; 49(1):204-14. PubMed ID: 19065678
    [Abstract] [Full Text] [Related]

  • 15. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
    Yang G, Murashige DS, Humphrey SJ, James DE.
    Cell Rep; 2015 Aug 11; 12(6):937-43. PubMed ID: 26235620
    [Abstract] [Full Text] [Related]

  • 16. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
    Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J.
    Biochem J; 1999 Feb 01; 337 ( Pt 3)(Pt 3):575-83. PubMed ID: 9895304
    [Abstract] [Full Text] [Related]

  • 17. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
    Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov DD.
    J Biol Chem; 2013 Sep 20; 288(38):27019-27030. PubMed ID: 23928304
    [Abstract] [Full Text] [Related]

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