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182 related items for PubMed ID: 23043506

  • 1. Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase.
    Liu YT, Hu TC, Chang CH, Shie WS, Wu TK.
    Org Lett; 2012 Oct 19; 14(20):5222-5. PubMed ID: 23043506
    [Abstract] [Full Text] [Related]

  • 2. Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
    Wu TK, Yu MT, Liu YT, Chang CH, Wang HJ, Diau EW.
    Org Lett; 2006 Mar 30; 8(7):1319-22. PubMed ID: 16562881
    [Abstract] [Full Text] [Related]

  • 3. Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions.
    Wu TK, Liu YT, Chang CH, Yu MT, Wang HJ.
    J Am Chem Soc; 2006 May 17; 128(19):6414-9. PubMed ID: 16683806
    [Abstract] [Full Text] [Related]

  • 4. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.
    Kimura M, Kushiro T, Shibuya M, Ebizuka Y, Abe I.
    Biochem Biophys Res Commun; 2010 Jan 01; 391(1):899-902. PubMed ID: 19951700
    [Abstract] [Full Text] [Related]

  • 5. [Construction of Saccharomyces cerevisiae haploid mutant deficient in lanosterol synthase gene].
    Gao LL, Wang QH, Liang HC, Gong T, Yang JL, Zhu P.
    Yao Xue Xue Bao; 2014 May 01; 49(5):742-6. PubMed ID: 25151749
    [Abstract] [Full Text] [Related]

  • 6. Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation.
    Matsuda SP, Darr LB, Hart EA, Herrera JB, McCann KE, Meyer MM, Pang J, Schepmann HG.
    Org Lett; 2000 Jul 27; 2(15):2261-3. PubMed ID: 10930258
    [Abstract] [Full Text] [Related]

  • 7. Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase.
    Chang CH, Wen HY, Shie WS, Lu CT, Li ME, Liu YT, Li WH, Wu TK.
    Org Biomol Chem; 2013 Jul 07; 11(25):4214-9. PubMed ID: 23680980
    [Abstract] [Full Text] [Related]

  • 8. Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships.
    Wu TK, Chang CH, Liu YT, Wang TT.
    Chem Rec; 2008 Jul 07; 8(5):302-25. PubMed ID: 18956480
    [Abstract] [Full Text] [Related]

  • 9. Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
    Wu TK, Liu YT, Chiu FH, Chang CH.
    Org Lett; 2006 Oct 12; 8(21):4691-4. PubMed ID: 17020279
    [Abstract] [Full Text] [Related]

  • 10. Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.
    Wu TK, Wang TT, Chang CH, Liu YT, Shie WS.
    Org Lett; 2008 Nov 06; 10(21):4959-62. PubMed ID: 18842050
    [Abstract] [Full Text] [Related]

  • 11. Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis.
    Segura MJ, Lodeiro S, Meyer MM, Patel AJ, Matsuda SP.
    Org Lett; 2002 Dec 12; 4(25):4459-62. PubMed ID: 12465912
    [Abstract] [Full Text] [Related]

  • 12. Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase.
    Lodeiro S, Schulz-Gasch T, Matsuda SP.
    J Am Chem Soc; 2005 Oct 19; 127(41):14132-3. PubMed ID: 16218577
    [Abstract] [Full Text] [Related]

  • 13. Oryza sativa Parkeol Cyclase: Changes in the Substrate-Folding Conformation and the Deprotonation Sites on Mutation at Tyr257: Importance of the Hydroxy Group and Steric Bulk.
    Suzuki A, Aikawa Y, Ito R, Hoshino T.
    Chembiochem; 2019 Nov 18; 20(22):2862-2875. PubMed ID: 31180162
    [Abstract] [Full Text] [Related]

  • 14. Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product.
    Wu TK, Wen HY, Chang CH, Liu YT.
    Org Lett; 2008 Jun 19; 10(12):2529-32. PubMed ID: 18494476
    [Abstract] [Full Text] [Related]

  • 15. Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana.
    Gas-Pascual E, Berna A, Bach TJ, Schaller H.
    PLoS One; 2014 Jun 19; 9(10):e109156. PubMed ID: 25343375
    [Abstract] [Full Text] [Related]

  • 16. [Downregulation of lanosterol synthase gene expression by antisense RNA technology in Saccharomyces cerevisiae].
    Wang QH, Gao LL, Liang HC, Du GH, Gong T, Yang JL, Zhu P.
    Yao Xue Xue Bao; 2015 Jan 19; 50(1):118-22. PubMed ID: 25924486
    [Abstract] [Full Text] [Related]

  • 17. The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid.
    Chang CH, Chen YC, Tseng SW, Liu YT, Wen HY, Li WH, Huang CY, Ko CY, Wang TT, Wu TK.
    Biochimie; 2012 Nov 19; 94(11):2376-81. PubMed ID: 22732192
    [Abstract] [Full Text] [Related]

  • 18. Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry.
    Wu TK, Chang YC, Liu YT, Chang CH, Wen HY, Li WH, Shie WS.
    Org Biomol Chem; 2011 Feb 21; 9(4):1092-7. PubMed ID: 21157613
    [Abstract] [Full Text] [Related]

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