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Journal Abstract Search

258 related items for PubMed ID: 2310416

  • 1.
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  • 3. Hydroxylation of the thiophene ring by hepatic monooxygenases. Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay.
    Neau E, Dansette PM, Andronik V, Mansuy D.
    Biochem Pharmacol; 1990 Mar 15; 39(6):1101-7. PubMed ID: 2322296
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  • 5. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
    López-Garcia MP, Dansette PM, Mansuy D.
    Biochemistry; 1994 Jan 11; 33(1):166-75. PubMed ID: 8286335
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  • 6. Differential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9.
    Rademacher PM, Woods CM, Huang Q, Szklarz GD, Nelson SD.
    Chem Res Toxicol; 2012 Apr 16; 25(4):895-903. PubMed ID: 22329513
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  • 7. Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat.
    Mansuy D, Dansette PM, Foures C, Jaouen M, Moinet G, Bayer N.
    Biochem Pharmacol; 1984 May 01; 33(9):1429-35. PubMed ID: 6732860
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  • 8. Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
    Bonierbale E, Valadon P, Pons C, Desfosses B, Dansette PM, Mansuy D.
    Chem Res Toxicol; 1999 Mar 01; 12(3):286-96. PubMed ID: 10077492
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  • 9. Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein.
    Masubuchi Y, Araki J, Narimatsu S, Suzuki T.
    Biochem Pharmacol; 1992 Jun 23; 43(12):2551-7. PubMed ID: 1632813
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  • 10. Molecular structure and hepatotoxicity: compared data about two closely related thiophene compounds.
    Mansuy D.
    J Hepatol; 1997 Jun 23; 26 Suppl 2():22-5. PubMed ID: 9204406
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  • 11. Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9.
    Jean P, Lopez-Garcia P, Dansette P, Mansuy D, Goldstein JL.
    Eur J Biochem; 1996 Nov 01; 241(3):797-804. PubMed ID: 8944768
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  • 12. In vitro metabolism of the antianxiety drug buspirone as a predictor of its metabolism in vivo.
    Jajoo HK, Blair IA, Klunk LJ, Mayol RF.
    Xenobiotica; 1990 Aug 01; 20(8):779-86. PubMed ID: 2219961
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  • 13. Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations.
    Miller KJ, Anderholm DC, Ames MM.
    Biochem Pharmacol; 1986 May 15; 35(10):1737-42. PubMed ID: 3707603
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  • 14. Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer.
    Coen M, Rademacher PM, Zou W, Scott M, Ganey PE, Roth R, Nelson SD.
    Chem Res Toxicol; 2012 Nov 19; 25(11):2412-22. PubMed ID: 23013248
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  • 15. Monooxygenase-mediated activation of chlorotrianisene (TACE) in covalent binding to rat hepatic microsomal proteins.
    Juedes MJ, Bulger WH, Kupfer D.
    Drug Metab Dispos; 1987 Nov 19; 15(6):786-93. PubMed ID: 2893703
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  • 17. Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.
    Valadon P, Dansette PM, Girault JP, Amar C, Mansuy D.
    Chem Res Toxicol; 1996 Dec 19; 9(8):1403-13. PubMed ID: 8951246
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  • 18. Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin.
    Vyas KP, Kari PH, Prakash SR, Duggan DE.
    Drug Metab Dispos; 1990 Dec 19; 18(2):218-22. PubMed ID: 1971576
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  • 19. Practolol metabolism. III. Irreversible binding of [14C]practolol metabolite(s) to mammalian liver microsomes.
    Orton TC, Lowery C.
    J Pharmacol Exp Ther; 1981 Oct 19; 219(1):207-12. PubMed ID: 6793710
    [Abstract] [Full Text] [Related]

  • 20. Metabolic activation of hydralazine by rat liver microsomes.
    LaCagnin LB, Colby HD, Dalal NS, O'Donnell JP.
    Biochem Pharmacol; 1987 Aug 15; 36(16):2667-72. PubMed ID: 3038130
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