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182 related items for PubMed ID: 23130825

  • 1. Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study.
    Tian BX, Eriksson LA.
    J Phys Chem B; 2012 Nov 29; 116(47):13857-62. PubMed ID: 23130825
    [Abstract] [Full Text] [Related]

  • 2. Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product.
    Wu TK, Wen HY, Chang CH, Liu YT.
    Org Lett; 2008 Jun 19; 10(12):2529-32. PubMed ID: 18494476
    [Abstract] [Full Text] [Related]

  • 3. The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid.
    Chang CH, Chen YC, Tseng SW, Liu YT, Wen HY, Li WH, Huang CY, Ko CY, Wang TT, Wu TK.
    Biochimie; 2012 Nov 19; 94(11):2376-81. PubMed ID: 22732192
    [Abstract] [Full Text] [Related]

  • 4. Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
    Wu TK, Yu MT, Liu YT, Chang CH, Wang HJ, Diau EW.
    Org Lett; 2006 Mar 30; 8(7):1319-22. PubMed ID: 16562881
    [Abstract] [Full Text] [Related]

  • 5. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
    Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A.
    Nature; 2004 Nov 04; 432(7013):118-22. PubMed ID: 15525992
    [Abstract] [Full Text] [Related]

  • 6. Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions.
    Wu TK, Liu YT, Chang CH, Yu MT, Wang HJ.
    J Am Chem Soc; 2006 May 17; 128(19):6414-9. PubMed ID: 16683806
    [Abstract] [Full Text] [Related]

  • 7. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.
    Kimura M, Kushiro T, Shibuya M, Ebizuka Y, Abe I.
    Biochem Biophys Res Commun; 2010 Jan 01; 391(1):899-902. PubMed ID: 19951700
    [Abstract] [Full Text] [Related]

  • 8. Biosynthetic Mechanism of Lanosterol: Cyclization.
    Chen N, Wang S, Smentek L, Hess BA, Wu R.
    Angew Chem Int Ed Engl; 2015 Jul 20; 54(30):8693-6. PubMed ID: 26069216
    [Abstract] [Full Text] [Related]

  • 9. Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase.
    Chang CH, Wen HY, Shie WS, Lu CT, Li ME, Liu YT, Li WH, Wu TK.
    Org Biomol Chem; 2013 Jul 07; 11(25):4214-9. PubMed ID: 23680980
    [Abstract] [Full Text] [Related]

  • 10. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.
    Huff MW, Telford DE.
    Trends Pharmacol Sci; 2005 Jul 07; 26(7):335-40. PubMed ID: 15951028
    [Abstract] [Full Text] [Related]

  • 11. Mechanistic insights into oxidosqualene cyclizations through homology modeling.
    Schulz-Gasch T, Stahl M.
    J Comput Chem; 2003 Apr 30; 24(6):741-53. PubMed ID: 12666166
    [Abstract] [Full Text] [Related]

  • 12. Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry.
    Wu TK, Chang YC, Liu YT, Chang CH, Wen HY, Li WH, Shie WS.
    Org Biomol Chem; 2011 Feb 21; 9(4):1092-7. PubMed ID: 21157613
    [Abstract] [Full Text] [Related]

  • 13. Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
    Wu TK, Liu YT, Chiu FH, Chang CH.
    Org Lett; 2006 Oct 12; 8(21):4691-4. PubMed ID: 17020279
    [Abstract] [Full Text] [Related]

  • 14. Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis.
    Takase S, Saga Y, Kurihara N, Naraki S, Kuze K, Nakata G, Araki T, Kushiro T.
    Org Biomol Chem; 2015 Jul 14; 13(26):7331-6. PubMed ID: 26058429
    [Abstract] [Full Text] [Related]

  • 15. Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase.
    Lodeiro S, Schulz-Gasch T, Matsuda SP.
    J Am Chem Soc; 2005 Oct 19; 127(41):14132-3. PubMed ID: 16218577
    [Abstract] [Full Text] [Related]

  • 16. Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution.
    Dang T, Prestwich GD.
    Chem Biol; 2000 Aug 19; 7(8):643-9. PubMed ID: 11048954
    [Abstract] [Full Text] [Related]

  • 17. Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae.
    Wu TK, Chang CH.
    Chembiochem; 2004 Dec 03; 5(12):1712-5. PubMed ID: 15508118
    [No Abstract] [Full Text] [Related]

  • 18. Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis.
    Wu TK, Griffin JH.
    Biochemistry; 2002 Jul 02; 41(26):8238-44. PubMed ID: 12081472
    [Abstract] [Full Text] [Related]

  • 19. Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions.
    Wu TK, Liu YT, Chang CH.
    Chembiochem; 2005 Jul 02; 6(7):1177-81. PubMed ID: 15915534
    [No Abstract] [Full Text] [Related]

  • 20. Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase.
    Liu YT, Hu TC, Chang CH, Shie WS, Wu TK.
    Org Lett; 2012 Oct 19; 14(20):5222-5. PubMed ID: 23043506
    [Abstract] [Full Text] [Related]

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