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Journal Abstract Search

276 related items for PubMed ID: 23136880

  • 1. Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.
    Hutcheson J, Vanarsa K, Bashmakov A, Grewal S, Sajitharan D, Chang BY, Buggy JJ, Zhou XJ, Du Y, Satterthwaite AB, Mohan C.
    Arthritis Res Ther; 2012 Nov 08; 14(6):R243. PubMed ID: 23136880
    [Abstract] [Full Text] [Related]

  • 2. Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus.
    Wakui M, Morel L, Butfiloski EJ, Kim C, Sobel ES.
    J Immunol; 2005 Jul 15; 175(2):1337-45. PubMed ID: 16002739
    [Abstract] [Full Text] [Related]

  • 3. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis.
    Liu K, Li QZ, Yu Y, Liang C, Subramanian S, Zeng Z, Wang HW, Xie C, Zhou XJ, Mohan C, Wakeland EK.
    Genes Immun; 2007 Dec 15; 8(8):634-45. PubMed ID: 17728789
    [Abstract] [Full Text] [Related]

  • 4. Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.
    Mohan C, Morel L, Yang P, Watanabe H, Croker B, Gilkeson G, Wakeland EK.
    J Clin Invest; 1999 Jun 15; 103(12):1685-95. PubMed ID: 10377175
    [Abstract] [Full Text] [Related]

  • 5. Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.
    Kil LP, de Bruijn MJ, van Nimwegen M, Corneth OB, van Hamburg JP, Dingjan GM, Thaiss F, Rimmelzwaan GF, Elewaut D, Delsing D, van Loo PF, Hendriks RW.
    Blood; 2012 Apr 19; 119(16):3744-56. PubMed ID: 22383797
    [Abstract] [Full Text] [Related]

  • 6. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.
    Morel L, Tian XH, Croker BP, Wakeland EK.
    Immunity; 1999 Aug 19; 11(2):131-9. PubMed ID: 10485648
    [Abstract] [Full Text] [Related]

  • 7. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.
    Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK.
    Proc Natl Acad Sci U S A; 2000 Jun 06; 97(12):6670-5. PubMed ID: 10841565
    [Abstract] [Full Text] [Related]

  • 8. BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis.
    Chalmers SA, Glynn E, Garcia SJ, Panzenbeck M, Pelletier J, Dimock J, Seccareccia E, Bosanac T, Khalil S, Harcken C, Webb D, Nabozny G, Fine JS, Souza D, Klein E, Herlitz L, Ramanujam M, Putterman C.
    Clin Immunol; 2018 Dec 06; 197():205-218. PubMed ID: 30339790
    [Abstract] [Full Text] [Related]

  • 9. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
    Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, Li S, Pan Z, Thamm DH, Miller RA, Buggy JJ.
    Proc Natl Acad Sci U S A; 2010 Jul 20; 107(29):13075-80. PubMed ID: 20615965
    [Abstract] [Full Text] [Related]

  • 10. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
    Rankin AL, Seth N, Keegan S, Andreyeva T, Cook TA, Edmonds J, Mathialagan N, Benson MJ, Syed J, Zhan Y, Benoit SE, Miyashiro JS, Wood N, Mohan S, Peeva E, Ramaiah SK, Messing D, Homer BL, Dunussi-Joannopoulos K, Nickerson-Nutter CL, Schnute ME, Douhan J.
    J Immunol; 2013 Nov 01; 191(9):4540-50. PubMed ID: 24068666
    [Abstract] [Full Text] [Related]

  • 11. Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice.
    Peters AL, Stunz LL, Meyerholz DK, Mohan C, Bishop GA.
    J Immunol; 2010 Oct 01; 185(7):4053-62. PubMed ID: 20810985
    [Abstract] [Full Text] [Related]

  • 12. Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.
    Loh C, Pau E, Lajoie G, Li TT, Baglaenko Y, Cheung YH, Chang NH, Wither JE.
    J Immunol; 2011 May 15; 186(10):5845-53. PubMed ID: 21464090
    [Abstract] [Full Text] [Related]

  • 13. Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.
    Xu Z, Duan B, Croker BP, Wakeland EK, Morel L.
    J Immunol; 2005 Jul 15; 175(2):936-43. PubMed ID: 16002692
    [Abstract] [Full Text] [Related]

  • 14. CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis.
    Shi X, Xie C, Chang S, Zhou XJ, Tedder T, Mohan C.
    Arthritis Rheum; 2007 Sep 15; 56(9):3057-69. PubMed ID: 17763445
    [Abstract] [Full Text] [Related]

  • 15. IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions.
    Wan S, Xia C, Morel L.
    J Immunol; 2007 Jan 01; 178(1):271-9. PubMed ID: 17182564
    [Abstract] [Full Text] [Related]

  • 16. Btk inhibition treats TLR7/IFN driven murine lupus.
    Bender AT, Pereira A, Fu K, Samy E, Wu Y, Liu-Bujalski L, Caldwell R, Chen YY, Tian H, Morandi F, Head J, Koehler U, Genest M, Okitsu SL, Xu D, Grenningloh R.
    Clin Immunol; 2016 Mar 01; 164():65-77. PubMed ID: 26821304
    [Abstract] [Full Text] [Related]

  • 17. Constitutive overexpression of BAFF in autoimmune-resistant mice drives only some aspects of systemic lupus erythematosus-like autoimmunity.
    Stohl W, Jacob N, Guo S, Morel L.
    Arthritis Rheum; 2010 Aug 01; 62(8):2432-42. PubMed ID: 20506216
    [Abstract] [Full Text] [Related]

  • 18. Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
    Katewa A, Wang Y, Hackney JA, Huang T, Suto E, Ramamoorthi N, Austin CD, Bremer M, Chen JZ, Crawford JJ, Currie KS, Blomgren P, DeVoss J, DiPaolo JA, Hau J, Johnson A, Lesch J, DeForge LE, Lin Z, Liimatta M, Lubach JW, McVay S, Modrusan Z, Nguyen A, Poon C, Wang J, Liu L, Lee WP, Wong H, Young WB, Townsend MJ, Reif K.
    JCI Insight; 2017 Apr 06; 2(7):e90111. PubMed ID: 28405610
    [Abstract] [Full Text] [Related]

  • 19. Yaa autoimmune phenotypes are conferred by overexpression of TLR7.
    Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK.
    Eur J Immunol; 2008 Jul 06; 38(7):1971-8. PubMed ID: 18521959
    [Abstract] [Full Text] [Related]

  • 20. Targeting Bruton's tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments.
    Tavakoli GM, Yazdanpanah N, Rezaei N.
    Adv Rheumatol; 2024 Aug 21; 64(1):61. PubMed ID: 39169436
    [Abstract] [Full Text] [Related]

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