These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

137 related items for PubMed ID: 23139381

  • 1. Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
    Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL.
    J Biomol Screen; 2013 Mar; 18(3):298-308. PubMed ID: 23139381
    [Abstract] [Full Text] [Related]

  • 2. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.
    Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A, McAndrews C, Rowlands MG, Morgan GJ, Aherne W, Collins I, Davies FE, Pearl LH.
    EMBO J; 2011 Mar 02; 30(5):894-905. PubMed ID: 21317875
    [Abstract] [Full Text] [Related]

  • 3. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
    Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.
    Blood; 2012 Jun 14; 119(24):5772-81. PubMed ID: 22538852
    [Abstract] [Full Text] [Related]

  • 4. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
    Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ.
    Nat Chem Biol; 2021 Nov 14; 17(11):1148-1156. PubMed ID: 34556859
    [Abstract] [Full Text] [Related]

  • 5. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
    Concha NO, Smallwood A, Bonnette W, Totoritis R, Zhang G, Federowicz K, Yang J, Qi H, Chen S, Campobasso N, Choudhry AE, Shuster LE, Evans KA, Ralph J, Sweitzer S, Heerding DA, Buser CA, Su DS, DeYoung MP.
    Mol Pharmacol; 2015 Dec 14; 88(6):1011-23. PubMed ID: 26438213
    [Abstract] [Full Text] [Related]

  • 6. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
    Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, Mok NY, Newbatt Y, Pickard L, Strover J, Hedayat S, Walton MI, Myers SM, Jones AM, Saville H, McAndrew C, Burke R, Eccles SA, Davies FE, Bayliss R, Collins I.
    J Med Chem; 2019 Mar 14; 62(5):2447-2465. PubMed ID: 30779566
    [Abstract] [Full Text] [Related]

  • 7. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
    Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.
    Cell; 2014 Jul 31; 158(3):534-48. PubMed ID: 25018104
    [Abstract] [Full Text] [Related]

  • 8. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
    Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ.
    ACS Chem Biol; 2016 Aug 19; 11(8):2195-205. PubMed ID: 27227314
    [Abstract] [Full Text] [Related]

  • 9. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
    Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.
    J Biol Chem; 2011 Apr 08; 286(14):12743-55. PubMed ID: 21303903
    [Abstract] [Full Text] [Related]

  • 10. Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
    Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A.
    Proc Natl Acad Sci U S A; 2019 Aug 13; 116(33):16420-16429. PubMed ID: 31371506
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological Targeting of IRE1 in Cancer.
    Raymundo DP, Doultsinos D, Guillory X, Carlesso A, Eriksson LA, Chevet E.
    Trends Cancer; 2020 Dec 13; 6(12):1018-1030. PubMed ID: 32861679
    [Abstract] [Full Text] [Related]

  • 12. Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch.
    Tashiro E.
    J Antibiot (Tokyo); 2019 Dec 13; 72(12):899-905. PubMed ID: 31399644
    [Abstract] [Full Text] [Related]

  • 13. The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus.
    Fung TS, Liao Y, Liu DX.
    J Virol; 2014 Nov 13; 88(21):12752-64. PubMed ID: 25142592
    [Abstract] [Full Text] [Related]

  • 14. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
    Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ.
    Nat Chem Biol; 2012 Dec 13; 8(12):982-9. PubMed ID: 23086298
    [Abstract] [Full Text] [Related]

  • 15. Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.
    Itzhak D, Bright M, McAndrew P, Mirza A, Newbatt Y, Strover J, Widya M, Thompson A, Morgan G, Collins I, Davies F.
    BMC Biochem; 2014 Feb 13; 15():3. PubMed ID: 24524643
    [Abstract] [Full Text] [Related]

  • 16. Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
    Su A, Wang H, Li Y, Wang X, Chen D, Wu Z.
    Viruses; 2017 Aug 23; 9(9):. PubMed ID: 28832521
    [Abstract] [Full Text] [Related]

  • 17. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.
    Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC.
    Mol Cancer Ther; 2016 Sep 23; 15(9):2055-65. PubMed ID: 27307600
    [Abstract] [Full Text] [Related]

  • 18. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
    Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ.
    J Clin Invest; 2005 Feb 23; 115(2):268-81. PubMed ID: 15690081
    [Abstract] [Full Text] [Related]

  • 19. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
    Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.
    Cell; 2009 Aug 07; 138(3):562-75. PubMed ID: 19665977
    [Abstract] [Full Text] [Related]

  • 20. Inositol-Requiring Enzyme 1α Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism.
    Huang Y, Lin Q, Huo Z, Chen C, Zhou S, Ma X, Gao H, Lin Y, Li X, He J, Zhang P, Liu C.
    J Virol; 2020 Nov 09; 94(23):. PubMed ID: 32967957
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 7.