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152 related items for PubMed ID: 23223498

  • 1. Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.
    Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF.
    Drug Metab Dispos; 2013 Feb; 41(2):518-28. PubMed ID: 23223498
    [Abstract] [Full Text] [Related]

  • 2. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
    Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE.
    Drug Metab Dispos; 2006 Dec; 34(12):1985-94. PubMed ID: 16997912
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  • 3. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
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  • 8. Application of a higher throughput approach to derive apparent Michaelis-Menten constants of isoform-selective p450-mediated biotransformation reactions in human hepatocytes.
    Li AP, Schlicht KE.
    Drug Metab Lett; 2014 Jul; 8(1):2-11. PubMed ID: 24910237
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  • 10. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.
    Gallagher EP, Kunze KL, Stapleton PL, Eaton DL.
    Toxicol Appl Pharmacol; 1996 Dec; 141(2):595-606. PubMed ID: 8975785
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  • 12. Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
    Khojasteh-Bakht SC, Rossulek MI, Fouda HG, Prakash C.
    Xenobiotica; 2003 Dec; 33(12):1201-10. PubMed ID: 14742142
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  • 14. Interaction between 3,4‑dichlorophenyl‑propenoyl‑sec.‑butylamine (3,4‑DCPB), an antiepileptic drug, and cytochrome P450 in rat liver microsomes and recombinant human enzymes in vitro.
    Cheng HX, Lu YY, Wang X, Ren H, Li Q, Wang SM, Ding Y, Lou YQ, Zhang GL.
    Eur J Pharm Sci; 2018 Oct 15; 123():241-248. PubMed ID: 30010032
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  • 15. In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices.
    Rodrigues AD, Mulford DJ, Lee RD, Surber BW, Kukulka MJ, Ferrero JL, Thomas SB, Shet MS, Estabrook RW.
    Drug Metab Dispos; 1995 Jul 15; 23(7):765-75. PubMed ID: 7587966
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  • 16. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
    Xu L, Woodward C, Khan S, Prakash C.
    Drug Metab Dispos; 2012 Apr 15; 40(4):680-93. PubMed ID: 22217465
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  • 18. Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1.
    Ozawa S, Ohta K, Miyajima A, Kurebayashi H, Sunouchi M, Shimizu M, Murayama N, Matsumoto Y, Fukuoka M, Ohno Y.
    Xenobiotica; 2000 Oct 15; 30(10):1005-17. PubMed ID: 11315102
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  • 19. In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2,3,5-trimethoxy-xanthone purified from Halenia elliptica D. Don.
    Feng R, Zhou X, Tan XS, Or PM, Hu T, Fu J, Ma JY, Huang M, He CY, Shi JG, Che CT, Yeung JH, Wang Y.
    Chem Biol Interact; 2014 Mar 05; 210():12-9. PubMed ID: 24380714
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  • 20. The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
    Chapron BD, Dinh JC, Toren PC, Gaedigk A, Leeder JS.
    Drug Metab Dispos; 2020 Nov 05; 48(11):1113-1120. PubMed ID: 32847865
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