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Journal Abstract Search

247 related items for PubMed ID: 23227175

  • 1. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
    James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT.
    PLoS One; 2012; 7(12):e50457. PubMed ID: 23227175
    [Abstract] [Full Text] [Related]

  • 2. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.
    Haikarainen T, Venkannagari H, Narwal M, Obaji E, Lee HW, Nkizinkiko Y, Lehtiö L.
    PLoS One; 2013; 8(6):e65404. PubMed ID: 23762361
    [Abstract] [Full Text] [Related]

  • 3. The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase.
    Okada-Iwasaki R, Takahashi Y, Watanabe Y, Ishida H, Saito J, Nakai R, Asai A.
    Mol Cancer Ther; 2016 Jul; 15(7):1525-34. PubMed ID: 27196752
    [Abstract] [Full Text] [Related]

  • 4. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
    Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.
    Nature; 2009 Oct 01; 461(7264):614-20. PubMed ID: 19759537
    [Abstract] [Full Text] [Related]

  • 5. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
    Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.
    Cancer Res; 2013 May 15; 73(10):3132-44. PubMed ID: 23539443
    [Abstract] [Full Text] [Related]

  • 6. Evidence for tankyrases as antineoplastic targets in lung cancer.
    Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.
    BMC Cancer; 2013 Apr 28; 13():211. PubMed ID: 23621985
    [Abstract] [Full Text] [Related]

  • 7. mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.
    Mashima T, Taneda Y, Jang MK, Mizutani A, Muramatsu Y, Yoshida H, Sato A, Tanaka N, Sugimoto Y, Seimiya H.
    Oncotarget; 2017 Jul 18; 8(29):47902-47915. PubMed ID: 28615517
    [Abstract] [Full Text] [Related]

  • 8. Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
    J Med Chem; 2019 Apr 11; 62(7):3407-3427. PubMed ID: 30883102
    [Abstract] [Full Text] [Related]

  • 9. Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.
    Martino-Echarri E, Brocardo MG, Mills KM, Henderson BR.
    PLoS One; 2016 Apr 11; 11(3):e0150484. PubMed ID: 26930278
    [Abstract] [Full Text] [Related]

  • 10. Tankyrase is necessary for canonical Wnt signaling during kidney development.
    Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ.
    Dev Dyn; 2010 Jul 11; 239(7):2014-23. PubMed ID: 20549720
    [Abstract] [Full Text] [Related]

  • 11. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
    Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M.
    PLoS One; 2011 Jul 11; 6(7):e22595. PubMed ID: 21799911
    [Abstract] [Full Text] [Related]

  • 12. Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
    Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H.
    Mol Cancer Res; 2015 Nov 11; 13(11):1487-501. PubMed ID: 26124443
    [Abstract] [Full Text] [Related]

  • 13. Drug discovery: Propping up a destructive regime.
    Peterson RT.
    Nature; 2009 Oct 01; 461(7264):599-600. PubMed ID: 19794479
    [No Abstract] [Full Text] [Related]

  • 14. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
    Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L.
    Mol Cell Biol; 2015 Jul 01; 35(14):2425-35. PubMed ID: 25939383
    [Abstract] [Full Text] [Related]

  • 15. Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.
    Ma L, Wang X, Jia T, Wei W, Chua MS, So S.
    Oncotarget; 2015 Sep 22; 6(28):25390-401. PubMed ID: 26246473
    [Abstract] [Full Text] [Related]

  • 16. APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
    Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.
    Mol Cancer Ther; 2017 Apr 22; 16(4):752-762. PubMed ID: 28179481
    [Abstract] [Full Text] [Related]

  • 17. Ubiquitin conjugating enzyme E2 M promotes apoptosis in osteoarthritis chondrocytes via Wnt/β-catenin signaling.
    Ba C, Ni X, Yu J, Zou G, Zhu H.
    Biochem Biophys Res Commun; 2020 Sep 03; 529(4):970-976. PubMed ID: 32819607
    [Abstract] [Full Text] [Related]

  • 18. TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer.
    Solberg NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S.
    Mol Cancer Res; 2018 Mar 03; 16(3):543-553. PubMed ID: 29222171
    [Abstract] [Full Text] [Related]

  • 19. Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening.
    Li B, Liang J, Lu F, Zeng G, Zhang J, Ma Y, Liu P, Wang Q, Zhou Q, Chen L.
    Molecules; 2020 Apr 06; 25(7):. PubMed ID: 32268564
    [Abstract] [Full Text] [Related]

  • 20. The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.
    Croy HE, Fuller CN, Giannotti J, Robinson P, Foley AVA, Yamulla RJ, Cosgriff S, Greaves BD, von Kleeck RA, An HH, Powers CM, Tran JK, Tocker AM, Jacob KD, Davis BK, Roberts DM.
    J Biol Chem; 2016 Jun 10; 291(24):12747-12760. PubMed ID: 27068743
    [Abstract] [Full Text] [Related]

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