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375 related items for PubMed ID: 23246572

  • 1. An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.
    Lin H, Kolosenko I, Björklund AC, Protsyuk D, Österborg A, Grandér D, Tamm KP.
    Exp Cell Res; 2013 Mar 10; 319(5):600-11. PubMed ID: 23246572
    [Abstract] [Full Text] [Related]

  • 2. Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.
    Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F.
    Clin Cancer Res; 2012 Apr 01; 18(7):1888-900. PubMed ID: 22351691
    [Abstract] [Full Text] [Related]

  • 3. Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.
    Davenport EL, Zeisig A, Aronson LI, Moore HE, Hockley S, Gonzalez D, Smith EM, Powers MV, Sharp SY, Workman P, Morgan GJ, Davies FE.
    Leukemia; 2010 Oct 01; 24(10):1804-7. PubMed ID: 20703255
    [No Abstract] [Full Text] [Related]

  • 4. Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.
    Palacios C, Martín-Pérez R, López-Pérez AI, Pandiella A, López-Rivas A.
    Leuk Res; 2010 Nov 01; 34(11):1533-8. PubMed ID: 20667592
    [Abstract] [Full Text] [Related]

  • 5. Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells.
    Mellatyar H, Talaei S, Nejati-Koshki K, Akbarzadeh A.
    Asian Pac J Cancer Prev; 2016 Nov 01; 17(5):2453-7. PubMed ID: 27268613
    [Abstract] [Full Text] [Related]

  • 6. IL-6 activated JAK/STAT3 pathway and sensitivity to Hsp90 inhibitors in multiple myeloma.
    Kolosenko I, Grander D, Tamm KP.
    Curr Med Chem; 2014 Nov 01; 21(26):3042-7. PubMed ID: 24735367
    [Abstract] [Full Text] [Related]

  • 7. Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.
    Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM.
    Clin Cancer Res; 2006 Nov 15; 12(22):6826-35. PubMed ID: 17121904
    [Abstract] [Full Text] [Related]

  • 8. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM.
    Cancer Chemother Pharmacol; 2005 Aug 15; 56(2):126-37. PubMed ID: 15841378
    [Abstract] [Full Text] [Related]

  • 9. Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
    Heo JY, Kim HJ, Kim SM, Park KR, Park SY, Kim SW, Nam D, Jang HJ, Lee SG, Ahn KS, Kim SH, Shim BS, Choi SH, Ahn KS.
    Cancer Lett; 2011 Sep 01; 308(1):71-80. PubMed ID: 21565443
    [Abstract] [Full Text] [Related]

  • 10. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity.
    Thyrell L, Arulampalam V, Hjortsberg L, Farnebo M, Grandér D, Pokrovskaja Tamm K.
    Exp Cell Res; 2007 Nov 15; 313(19):4015-24. PubMed ID: 17880940
    [Abstract] [Full Text] [Related]

  • 11. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells.
    Monaghan KA, Khong T, Burns CJ, Spencer A.
    Leukemia; 2011 Dec 15; 25(12):1891-9. PubMed ID: 21788946
    [Abstract] [Full Text] [Related]

  • 12. IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1.
    Song L, Li Y, Sun YX, Yu M, Shen BF.
    Ai Zheng; 2002 Feb 15; 21(2):113-6. PubMed ID: 12479056
    [Abstract] [Full Text] [Related]

  • 13. [Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].
    Yu WJ, Rao Q, Wang M, Tian Z, Xu ZF, Wang JX.
    Zhonghua Xue Ye Xue Za Zhi; 2007 Oct 15; 28(10):677-80. PubMed ID: 18399173
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of hsp90 compromises the DNA damage response to radiation.
    Dote H, Burgan WE, Camphausen K, Tofilon PJ.
    Cancer Res; 2006 Sep 15; 66(18):9211-20. PubMed ID: 16982765
    [Abstract] [Full Text] [Related]

  • 15. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.
    Kim SH, Ahn KS, Jeong SJ, Kwon TR, Jung JH, Yun SM, Han I, Lee SG, Kim DK, Kang M, Chen CY, Lee JW, Kim SH.
    Eur J Pharmacol; 2011 Mar 01; 654(1):10-6. PubMed ID: 21172343
    [Abstract] [Full Text] [Related]

  • 16. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
    Schwock J, Pham NA, Cao MP, Hedley DW.
    Cancer Chemother Pharmacol; 2008 Apr 01; 61(4):669-81. PubMed ID: 17579866
    [Abstract] [Full Text] [Related]

  • 17. Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.
    Shi L, Zhang Z, Fang S, Xu J, Liu J, Shen J, Fang F, Luo L, Yin Z.
    Mol Immunol; 2009 Feb 01; 46(4):541-50. PubMed ID: 18950863
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV, Li Y, Rassidakis GZ, Martinez-Valdez H, Medeiros LJ, Younes A.
    Clin Cancer Res; 2006 Jan 15; 12(2):584-90. PubMed ID: 16428504
    [Abstract] [Full Text] [Related]

  • 19. Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation.
    Fionda C, Soriani A, Malgarini G, Iannitto ML, Santoni A, Cippitelli M.
    J Immunol; 2009 Oct 01; 183(7):4385-94. PubMed ID: 19748980
    [Abstract] [Full Text] [Related]

  • 20. 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.
    Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.
    Invest Ophthalmol Vis Sci; 2008 Jun 01; 49(6):2348-56. PubMed ID: 18281615
    [Abstract] [Full Text] [Related]

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