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325 related items for PubMed ID: 23252716

  • 1. Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
    Lennard L, Cartwright CS, Wade R, Richards SM, Vora A.
    Br J Clin Pharmacol; 2013 Jul; 76(1):125-36. PubMed ID: 23252716
    [Abstract] [Full Text] [Related]

  • 2. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
    Lennard L, Welch JC, Lilleyman JS.
    Br J Clin Pharmacol; 1997 Nov; 44(5):455-61. PubMed ID: 9384462
    [Abstract] [Full Text] [Related]

  • 3. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
    Relling MV, Hancock ML, Rivera GK, Sandlund JT, Ribeiro RC, Krynetski EY, Pui CH, Evans WE.
    J Natl Cancer Inst; 1999 Dec 01; 91(23):2001-8. PubMed ID: 10580024
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  • 5. Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.
    Adam de Beaumais T, Fakhoury M, Medard Y, Azougagh S, Zhang D, Yakouben K, Jacqz-Aigrain E.
    Br J Clin Pharmacol; 2011 Apr 01; 71(4):575-84. PubMed ID: 21395650
    [Abstract] [Full Text] [Related]

  • 6. No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
    Nielsen SN, Toksvang LN, Grell K, Nersting J, Abrahamsson J, Lund B, Kanerva J, Jónsson ÓG, Vaitkeviciene G, Pruunsild K, Appell ML, Hjalgrim LL, Schmiegelow K.
    Cancer Chemother Pharmacol; 2021 Aug 01; 88(2):271-279. PubMed ID: 33928426
    [Abstract] [Full Text] [Related]

  • 7. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia.
    Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM.
    Lancet; 1990 Jul 28; 336(8709):225-9. PubMed ID: 1973780
    [Abstract] [Full Text] [Related]

  • 8. Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies.
    Lennard L, Lewis IJ, Michelagnoli M, Lilleyman JS.
    Med Pediatr Oncol; 1997 Oct 28; 29(4):252-5. PubMed ID: 9251729
    [Abstract] [Full Text] [Related]

  • 9. Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.
    Lennard L, Cartwright CS, Wade R, Vora A.
    Br J Haematol; 2015 Apr 28; 169(2):228-40. PubMed ID: 25441457
    [Abstract] [Full Text] [Related]

  • 10. High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
    van Egmond R, Chin P, Zhang M, Sies CW, Barclay ML.
    Aliment Pharmacol Ther; 2012 May 28; 35(10):1181-9. PubMed ID: 22486532
    [Abstract] [Full Text] [Related]

  • 11. Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?
    Fakhoury M, Andreu-Gallien J, Mahr A, Medard Y, Azougagh S, Vilmer E, Jacqz-Aigrain E.
    J Clin Pharm Ther; 2007 Dec 28; 32(6):633-9. PubMed ID: 18021342
    [Abstract] [Full Text] [Related]

  • 12. Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.
    Bayoumy AB, Mulder CJJ, Loganayagam A, Sanderson JD, Anderson S, Boekema PJ, Derijks LJJ, Ansari AR.
    Ther Drug Monit; 2021 Oct 01; 43(5):617-623. PubMed ID: 34521801
    [Abstract] [Full Text] [Related]

  • 13. Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
    Levinsen M, Rosthøj S, Nygaard U, Heldrup J, Harila-Saari A, Jonsson OG, Bechensteen AG, Abrahamsson J, Lausen B, Frandsen TL, Weinshilboum RM, Schmiegelow K.
    Cancer Chemother Pharmacol; 2015 Jan 01; 75(1):59-66. PubMed ID: 25347948
    [Abstract] [Full Text] [Related]

  • 14. Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: a comparison of haematological toxicity and drug metabolite concentrations.
    Lancaster DL, Lennard L, Rowland K, Vora AJ, Lilleyman JS.
    Br J Haematol; 1998 Jul 01; 102(2):439-43. PubMed ID: 9695957
    [Abstract] [Full Text] [Related]

  • 15. Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
    Stanulla M, Schaeffeler E, Flohr T, Cario G, Schrauder A, Zimmermann M, Welte K, Ludwig WD, Bartram CR, Zanger UM, Eichelbaum M, Schrappe M, Schwab M.
    JAMA; 2005 Mar 23; 293(12):1485-9. PubMed ID: 15784872
    [Abstract] [Full Text] [Related]

  • 16. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
    Hawwa AF, Millership JS, Collier PS, Vandenbroeck K, McCarthy A, Dempsey S, Cairns C, Collins J, Rodgers C, McElnay JC.
    Br J Clin Pharmacol; 2008 Oct 23; 66(4):517-28. PubMed ID: 18662289
    [Abstract] [Full Text] [Related]

  • 17. Thiopurine S-methyltransferase phenotype-genotype correlation in children with acute lymphoblastic leukemia.
    Chrzanowska M, Kuehn M, Januszkiewicz-Lewandowska D, Kurzawski M, Droździk M.
    Acta Pol Pharm; 2012 Oct 23; 69(3):405-10. PubMed ID: 22594254
    [Abstract] [Full Text] [Related]

  • 18. Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
    Pettersson B, Almer S, Albertioni F, Söderhäll S, Peterson C.
    Ther Drug Monit; 2002 Jun 23; 24(3):351-8. PubMed ID: 12021625
    [Abstract] [Full Text] [Related]

  • 19. Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.
    Duley JA, Florin TH.
    Ther Drug Monit; 2005 Oct 23; 27(5):647-54. PubMed ID: 16175140
    [Abstract] [Full Text] [Related]

  • 20. Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.
    Gearry RB, Barclay ML, Roberts RL, Harraway J, Zhang M, Pike LS, George PM, Florkowski CM.
    Intern Med J; 2005 Oct 23; 35(10):580-5. PubMed ID: 16207256
    [Abstract] [Full Text] [Related]

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