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Journal Abstract Search

253 related items for PubMed ID: 23275438

  • 1. Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
    Zurashvili T, Cordón-Barris L, Ruiz-Babot G, Zhou X, Lizcano JM, Gómez N, Giménez-Llort L, Bayascas JR.
    Mol Cell Biol; 2013 Mar; 33(5):1027-40. PubMed ID: 23275438
    [Abstract] [Full Text] [Related]

  • 2. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
    McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR.
    EMBO J; 2004 May 19; 23(10):2071-82. PubMed ID: 15116068
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  • 3. Serine 396 of PDK1 is required for maximal PKB activation.
    Moon Z, Wang Y, Aryan N, Mousseau DD, Scheid MP.
    Cell Signal; 2008 Nov 19; 20(11):2038-49. PubMed ID: 18718528
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  • 4. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
    Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.
    Curr Biol; 1997 Oct 01; 7(10):776-89. PubMed ID: 9368760
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  • 5. Fine-tuning the intensity of the PKB/Akt signal enables diverse physiological responses.
    Zhou X, Cordon-Barris L, Zurashvili T, Bayascas JR.
    Cell Cycle; 2014 Oct 01; 13(20):3164-8. PubMed ID: 25485494
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  • 6. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
    Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.
    Curr Biol; 2000 Apr 20; 10(8):439-48. PubMed ID: 10801415
    [Abstract] [Full Text] [Related]

  • 7. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
    Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR.
    Mol Cell Biol; 2008 May 20; 28(10):3258-72. PubMed ID: 18347057
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  • 9. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
    Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J.
    Biochem J; 1999 Feb 01; 337 ( Pt 3)(Pt 3):575-83. PubMed ID: 9895304
    [Abstract] [Full Text] [Related]

  • 10. Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
    Liao XH, Buggey J, Kimmel AR.
    J Cell Sci; 2010 Mar 15; 123(Pt 6):983-92. PubMed ID: 20200230
    [Abstract] [Full Text] [Related]

  • 11. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
    Najafov A, Shpiro N, Alessi DR.
    Biochem J; 2012 Dec 01; 448(2):285-95. PubMed ID: 23030823
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  • 14. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
    Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.
    J Cell Sci; 2005 Nov 01; 118(Pt 21):5023-34. PubMed ID: 16219676
    [Abstract] [Full Text] [Related]

  • 15. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
    Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR.
    EMBO J; 2003 Aug 15; 22(16):4202-11. PubMed ID: 12912918
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  • 17. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
    Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR.
    Curr Biol; 1999 Apr 22; 9(8):393-404. PubMed ID: 10226025
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  • 18. PDK1, the master regulator of AGC kinase signal transduction.
    Mora A, Komander D, van Aalten DM, Alessi DR.
    Semin Cell Dev Biol; 2004 Apr 22; 15(2):161-70. PubMed ID: 15209375
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  • 19. Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.
    Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D.
    Mol Cell Biol; 2009 Nov 22; 29(21):5952-62. PubMed ID: 19703999
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