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348 related items for PubMed ID: 23275618

  • 1. Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
    Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.
    Am J Physiol Gastrointest Liver Physiol; 2013 Mar 01; 304(5):G527-35. PubMed ID: 23275618
    [Abstract] [Full Text] [Related]

  • 2. Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA.
    Yu X, Zhang Q, Zhao Y, Schwarz BJ, Stallone JN, Heaps CL, Han G.
    PLoS One; 2017 Mar 01; 12(3):e0173085. PubMed ID: 28278256
    [Abstract] [Full Text] [Related]

  • 3. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.
    Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV.
    J Biol Chem; 2011 May 13; 286(19):16681-92. PubMed ID: 21454546
    [Abstract] [Full Text] [Related]

  • 4. Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA.
    Sriwai W, Mahavadi S, Al-Shboul O, Grider JR, Murthy KS.
    PLoS One; 2013 May 13; 8(6):e66743. PubMed ID: 23825105
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA.
    Murthy KS, Zhou H, Grider JR, Makhlouf GM.
    Am J Physiol Gastrointest Liver Physiol; 2003 Jun 13; 284(6):G1006-16. PubMed ID: 12736149
    [Abstract] [Full Text] [Related]

  • 6. Epac as a novel effector of airway smooth muscle relaxation.
    Roscioni SS, Maarsingh H, Elzinga CR, Schuur J, Menzen M, Halayko AJ, Meurs H, Schmidt M.
    J Cell Mol Med; 2011 Jul 13; 15(7):1551-63. PubMed ID: 20716113
    [Abstract] [Full Text] [Related]

  • 7. G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA.
    Sriwai W, Zhou H, Murthy KS.
    Biochem J; 2008 May 01; 411(3):543-51. PubMed ID: 18237278
    [Abstract] [Full Text] [Related]

  • 8. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Roscioni SS, Kistemaker LE, Menzen MH, Elzinga CR, Gosens R, Halayko AJ, Meurs H, Schmidt M.
    Respir Res; 2009 Sep 29; 10(1):88. PubMed ID: 19788733
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.
    Nalli AD, Rajagopal S, Mahavadi S, Grider JR, Murthy KS.
    Am J Physiol Cell Physiol; 2015 Mar 15; 308(6):C485-95. PubMed ID: 25567809
    [Abstract] [Full Text] [Related]

  • 10. Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S.
    Bala V, Rajagopal S, Kumar DP, Nalli AD, Mahavadi S, Sanyal AJ, Grider JR, Murthy KS.
    Front Physiol; 2014 Mar 15; 5():420. PubMed ID: 25404917
    [Abstract] [Full Text] [Related]

  • 11. cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.
    Aslam M, Härtel FV, Arshad M, Gündüz D, Abdallah Y, Sauer H, Piper HM, Noll T.
    Cardiovasc Res; 2010 Jul 15; 87(2):375-84. PubMed ID: 20202976
    [Abstract] [Full Text] [Related]

  • 12. Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1.
    Bhattacharya S, Mahavadi S, Al-Shboul O, Rajagopal S, Grider JR, Murthy KS.
    Am J Physiol Cell Physiol; 2013 Aug 01; 305(3):C334-47. PubMed ID: 23784544
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide.
    Nalli AD, Wang H, Bhattacharya S, Blakeney BA, Murthy KS.
    Pharmacol Res Perspect; 2017 Oct 01; 5(5):. PubMed ID: 28971603
    [Abstract] [Full Text] [Related]

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  • 15. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Jeyaraj SC, Unger NT, Eid AH, Mitra S, Paul El-Dahdah N, Quilliam LA, Flavahan NA, Chotani MA.
    Am J Physiol Cell Physiol; 2012 Sep 01; 303(5):C499-511. PubMed ID: 22621783
    [Abstract] [Full Text] [Related]

  • 16. PKA and Epac synergistically inhibit smooth muscle cell proliferation.
    Hewer RC, Sala-Newby GB, Wu YJ, Newby AC, Bond M.
    J Mol Cell Cardiol; 2011 Jan 01; 50(1):87-98. PubMed ID: 20971121
    [Abstract] [Full Text] [Related]

  • 17. Diabetes-induced oxidative stress mediates upregulation of RhoA/Rho kinase pathway and hypercontractility of gastric smooth muscle.
    Mahavadi S, Sriwai W, Manion O, Grider JR, Murthy KS.
    PLoS One; 2017 Jan 01; 12(7):e0178574. PubMed ID: 28678840
    [Abstract] [Full Text] [Related]

  • 18. Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.
    Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Conway Morris A, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ.
    J Allergy Clin Immunol; 2016 Feb 01; 137(2):535-44. PubMed ID: 26388312
    [Abstract] [Full Text] [Related]

  • 19. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.
    Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Døskeland SO, Kristiansen K.
    Mol Cell Biol; 2008 Jun 01; 28(11):3804-16. PubMed ID: 18391018
    [Abstract] [Full Text] [Related]

  • 20. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.
    Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.
    Cell Signal; 2008 May 01; 20(5):803-14. PubMed ID: 18276108
    [Abstract] [Full Text] [Related]

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