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Journal Abstract Search

55 related items for PubMed ID: 23278303

  • 1. CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice.
    Giuliani A, Beggiato S, Baldassarro VA, Mangano C, Giardino L, Imbimbo BP, Antonelli T, Calzà L, Ferraro L.
    J Neurochem; 2013 Mar; 124(5):613-20. PubMed ID: 23278303
    [Abstract] [Full Text] [Related]

  • 2. CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice.
    Beggiato S, Giuliani A, Sivilia S, Lorenzini L, Antonelli T, Imbimbo BP, Giardino L, Calzà L, Ferraro L.
    Neuroscience; 2014 Apr 25; 266():13-22. PubMed ID: 24530449
    [Abstract] [Full Text] [Related]

  • 3. The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
    Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R.
    J Alzheimers Dis; 2011 Apr 25; 24(4):799-816. PubMed ID: 21321397
    [Abstract] [Full Text] [Related]

  • 4. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.
    Imbimbo BP, Giardino L, Sivilia S, Giuliani A, Gusciglio M, Pietrini V, Del Giudice E, D'Arrigo A, Leon A, Villetti G, Calzà L.
    J Alzheimers Dis; 2010 Apr 25; 20(1):159-73. PubMed ID: 20164581
    [Abstract] [Full Text] [Related]

  • 5. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.
    J Pharmacol Exp Ther; 2007 Dec 25; 323(3):822-30. PubMed ID: 17895400
    [Abstract] [Full Text] [Related]

  • 6. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
    Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, Calzà L, Flaibani R, Spano PF, Imbimbo BP, Pizzi M.
    Neuroscience; 2015 Aug 27; 302():112-20. PubMed ID: 25450955
    [Abstract] [Full Text] [Related]

  • 7. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
    Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L.
    BMC Neurosci; 2013 Apr 05; 14():44. PubMed ID: 23560952
    [Abstract] [Full Text] [Related]

  • 8. CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
    Imbimbo BP, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M.
    Br J Pharmacol; 2009 Mar 05; 156(6):982-93. PubMed ID: 19239474
    [Abstract] [Full Text] [Related]

  • 9. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
    Imbimbo BP, Del Giudice E, Cenacchi V, Volta R, Villetti G, Facchinetti F, Riccardi B, Puccini P, Moretto N, Grassi F, Ottonello S, Leon A.
    Pharmacol Res; 2007 Apr 05; 55(4):318-28. PubMed ID: 17292621
    [Abstract] [Full Text] [Related]

  • 10. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease.
    Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M.
    Brain Res; 2009 Jan 16; 1249():222-8. PubMed ID: 18996097
    [Abstract] [Full Text] [Related]

  • 11. Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie.
    Poli G, Corda E, Lucchini B, Puricelli M, Martino PA, Dall'ara P, Villetti G, Bareggi SR, Corona C, Vallino Costassa E, Gazzuola P, Iulini B, Mazza M, Acutis P, Mantegazza P, Casalone C, Imbimbo BP.
    Prion; 2012 Jan 16; 6(1):62-72. PubMed ID: 22453180
    [Abstract] [Full Text] [Related]

  • 12. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.
    Mango D, Barbato G, Piccirilli S, Panico MB, Feligioni M, Schepisi C, Graziani M, Porrini V, Benarese M, Lanzillotta A, Pizzi M, Pieraccini S, Sironi M, Blandini F, Nicoletti F, Mercuri NB, Imbimbo BP, Nisticò R.
    Pharmacol Res; 2014 Mar 16; 81():83-90. PubMed ID: 24630950
    [Abstract] [Full Text] [Related]

  • 13. CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro.
    Ronsisvalle N, Di Benedetto G, Parenti C, Amoroso S, Bernardini R, Cantarella G.
    Curr Alzheimer Res; 2014 Mar 16; 11(7):714-24. PubMed ID: 24938499
    [Abstract] [Full Text] [Related]

  • 14. Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease.
    Guzmán-Ramos K, Moreno-Castilla P, Castro-Cruz M, McGaugh JL, Martínez-Coria H, LaFerla FM, Bermúdez-Rattoni F.
    Learn Mem; 2012 Sep 14; 19(10):453-60. PubMed ID: 22984283
    [Abstract] [Full Text] [Related]

  • 15. Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.
    Porrini V, Sarnico I, Benarese M, Branca C, Mota M, Lanzillotta A, Bellucci A, Parrella E, Faggi L, Spano P, Imbimbo BP, Pizzi M.
    Int J Mol Sci; 2017 Jan 18; 18(1):. PubMed ID: 28106772
    [Abstract] [Full Text] [Related]

  • 16. Recognition memory and β-amyloid plaques in adult Tg2576 mice are not modified after oral exposure to aluminum.
    Ribes D, Torrente M, Vicens P, Colomina MT, Gómez M, Domingo JL.
    Alzheimer Dis Assoc Disord; 2012 Jan 18; 26(2):179-85. PubMed ID: 21642811
    [Abstract] [Full Text] [Related]

  • 17. Galanin inhibits acetylcholine release from rat cerebral cortex via a pertussis toxin-sensitive G(i)protein.
    Wang HY, Wild KD, Shank RP, Lee DH.
    Neuropeptides; 1999 Jun 18; 33(3):197-205. PubMed ID: 10657492
    [Abstract] [Full Text] [Related]

  • 18. Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease.
    Luo F, Rustay NR, Ebert U, Hradil VP, Cole TB, Llano DA, Mudd SR, Zhang Y, Fox GB, Day M.
    Neurobiol Aging; 2012 May 18; 33(5):933-44. PubMed ID: 20961663
    [Abstract] [Full Text] [Related]

  • 19. Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease.
    Ognibene E, Middei S, Daniele S, Adriani W, Ghirardi O, Caprioli A, Laviola G.
    Behav Brain Res; 2005 Jan 30; 156(2):225-32. PubMed ID: 15582108
    [Abstract] [Full Text] [Related]

  • 20. Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease.
    Aucoin JS, Jiang P, Aznavour N, Tong XK, Buttini M, Descarries L, Hamel E.
    Neuroscience; 2005 Jan 30; 132(1):73-86. PubMed ID: 15780468
    [Abstract] [Full Text] [Related]

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