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Journal Abstract Search

210 related items for PubMed ID: 23288866

  • 1.
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  • 2. Intestinal first-pass metabolism by cytochrome p450 and not p-glycoprotein is the major barrier to amprenavir absorption.
    Dufek MB, Bridges AS, Thakker DR.
    Drug Metab Dispos; 2013 Sep; 41(9):1695-702. PubMed ID: 23821186
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  • 3. P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine.
    Lagas JS, Damen CW, van Waterschoot RA, Iusuf D, Beijnen JH, Schinkel AH.
    Mol Pharmacol; 2012 Oct; 82(4):636-44. PubMed ID: 22767610
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  • 4. Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.
    Darwich AS, Neuhoff S, Jamei M, Rostami-Hodjegan A.
    Curr Drug Metab; 2010 Nov; 11(9):716-29. PubMed ID: 21189140
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  • 5. The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice.
    Press RR, Buckle T, Beijnen JH, van Tellingen O.
    Cancer Chemother Pharmacol; 2006 Jun; 57(6):819-25. PubMed ID: 16163538
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  • 6. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL.
    Kamath AV, Wang J, Lee FY, Marathe PH.
    Cancer Chemother Pharmacol; 2008 Mar; 61(3):365-76. PubMed ID: 17429625
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  • 8. Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats.
    Hirunpanich V, Murakoso K, Sato H.
    Int J Pharm; 2008 Mar 03; 351(1-2):133-43. PubMed ID: 18082981
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  • 10. P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
    Hendrikx JJ, Lagas JS, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.
    Int J Cancer; 2013 May 15; 132(10):2439-47. PubMed ID: 23090875
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  • 13. Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells.
    Ikemura K, Urano K, Matsuda H, Mizutani H, Iwamoto T, Okuda M.
    J Pharmacol Exp Ther; 2009 Jan 15; 328(1):249-55. PubMed ID: 18842703
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  • 14. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.
    Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ.
    J Pharmacol Exp Ther; 1998 Oct 15; 287(1):246-52. PubMed ID: 9765344
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  • 15. A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice.
    van Waterschoot RA, Schinkel AH.
    Pharmacol Rev; 2011 Jun 15; 63(2):390-410. PubMed ID: 21490128
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  • 17. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
    Cummins CL, Salphati L, Reid MJ, Benet LZ.
    J Pharmacol Exp Ther; 2003 Apr 15; 305(1):306-14. PubMed ID: 12649383
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  • 18. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .
    Lin JH, Chiba M, Chen IW, Nishime JA, deLuna FA, Yamazaki M, Lin YJ.
    Drug Metab Dispos; 1999 Oct 15; 27(10):1187-93. PubMed ID: 10497146
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  • 19. A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum.
    Johnson BM, Chen W, Borchardt RT, Charman WN, Porter CJ.
    J Pharmacol Exp Ther; 2003 Apr 15; 305(1):151-8. PubMed ID: 12649363
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  • 20. Investigation of the effect of the uneven distribution of CYP3A4 and P-glycoprotein in the intestine on the barrier function against xenobiotics: a simulation study.
    Watanabe T, Maeda K, Nakai C, Sugiyama Y.
    J Pharm Sci; 2013 Sep 15; 102(9):3196-204. PubMed ID: 23754337
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