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734 related items for PubMed ID: 23352505

  • 1. A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.
    Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A.
    Toxicol Appl Pharmacol; 2013 Apr 01; 268(1):1-16. PubMed ID: 23352505
    [Abstract] [Full Text] [Related]

  • 2. Preserved liver-specific functions of hepatocytes in 3D co-culture with endothelial cell sheets.
    Kim K, Ohashi K, Utoh R, Kano K, Okano T.
    Biomaterials; 2012 Feb 01; 33(5):1406-13. PubMed ID: 22118777
    [Abstract] [Full Text] [Related]

  • 3. Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.
    Schutte M, Fox B, Baradez MO, Devonshire A, Minguez J, Bokhari M, Przyborski S, Marshall D.
    Assay Drug Dev Technol; 2011 Oct 01; 9(5):475-86. PubMed ID: 21675871
    [Abstract] [Full Text] [Related]

  • 4. The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro.
    Thomas RJ, Bhandari R, Barrett DA, Bennett AJ, Fry JR, Powe D, Thomson BJ, Shakesheff KM.
    Cells Tissues Organs; 2005 Oct 01; 181(2):67-79. PubMed ID: 16534201
    [Abstract] [Full Text] [Related]

  • 5. Three-dimensional coculture of primary hepatocytes and stellate cells in silk scaffold improves hepatic morphology and functionality in vitro.
    Wei G, Wang J, Lv Q, Liu M, Xu H, Zhang H, Jin L, Yu J, Wang X.
    J Biomed Mater Res A; 2018 Aug 01; 106(8):2171-2180. PubMed ID: 29607608
    [Abstract] [Full Text] [Related]

  • 6. Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte-hepatic stellate cell interactions and flow effects.
    Lee SA, No da Y, Kang E, Ju J, Kim DS, Lee SH.
    Lab Chip; 2013 Sep 21; 13(18):3529-37. PubMed ID: 23657720
    [Abstract] [Full Text] [Related]

  • 7. Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.
    Richert L, Baze A, Parmentier C, Gerets HHJ, Sison-Young R, Dorau M, Lovatt C, Czich A, Goldring C, Park BK, Juhila S, Foster AJ, Williams DP.
    Toxicol Lett; 2016 Sep 06; 258():207-215. PubMed ID: 27363785
    [Abstract] [Full Text] [Related]

  • 8. Induction, expression and maintenance of cytochrome P450 isoforms in long-term cultures of primary human hepatocytes.
    Yuan J, Liu L, Shimada M, Wang A, Ruhnke M, Heeckt P, Muller AR, Nussler NC, Neuhaus P, Nussler A.
    ALTEX; 2004 Sep 06; 21 Suppl 3():3-11. PubMed ID: 15057403
    [Abstract] [Full Text] [Related]

  • 9. The suitability of hepatocyte culture models to study various aspects of drug metabolism.
    Nussler AK, Wang A, Neuhaus P, Fischer J, Yuan J, Liu L, Zeilinger K, Gerlach J, Arnold PJ, Albrecht W.
    ALTEX; 2001 Sep 06; 18(2):91-101. PubMed ID: 11378681
    [Abstract] [Full Text] [Related]

  • 10. Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies.
    Tuschl G, Hrach J, Walter Y, Hewitt PG, Mueller SO.
    Chem Biol Interact; 2009 Sep 14; 181(1):124-37. PubMed ID: 19482013
    [Abstract] [Full Text] [Related]

  • 11. Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities.
    Lan SF, Starly B.
    Toxicol Appl Pharmacol; 2011 Oct 01; 256(1):62-72. PubMed ID: 21839104
    [Abstract] [Full Text] [Related]

  • 12. Three-dimensional co-culture of primary human liver cells in bioreactors for in vitro drug studies: effects of the initial cell quality on the long-term maintenance of hepatocyte-specific functions.
    Zeilinger K, Sauer IM, Pless G, Strobel C, Rudzitis J, Wang A, Nüssler AK, Grebe A, Mao L, Auth SH, Unger J, Neuhaus P, Gerlach JC.
    Altern Lab Anim; 2002 Oct 01; 30(5):525-38. PubMed ID: 12405881
    [Abstract] [Full Text] [Related]

  • 13. Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.
    Nguyen DG, Funk J, Robbins JB, Crogan-Grundy C, Presnell SC, Singer T, Roth AB.
    PLoS One; 2016 Oct 01; 11(7):e0158674. PubMed ID: 27387377
    [Abstract] [Full Text] [Related]

  • 14. Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans.
    Atienzar FA, Novik EI, Gerets HH, Parekh A, Delatour C, Cardenas A, MacDonald J, Yarmush ML, Dhalluin S.
    Toxicol Appl Pharmacol; 2014 Feb 15; 275(1):44-61. PubMed ID: 24333257
    [Abstract] [Full Text] [Related]

  • 15. Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity.
    Novik EI, Dwyer J, Morelli JK, Parekh A, Cho C, Pludwinski E, Shrirao A, Freedman RM, MacDonald JS, Jayyosi Z.
    Toxicol Appl Pharmacol; 2017 Dec 01; 336():20-30. PubMed ID: 28942002
    [Abstract] [Full Text] [Related]

  • 16. Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen.
    Li AP, Uzgare A, LaForge YS.
    Chem Biol Interact; 2012 Jul 30; 199(1):1-8. PubMed ID: 22640811
    [Abstract] [Full Text] [Related]

  • 17. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
    Utkarsh D, Loretz C, Li AP.
    Chem Biol Interact; 2016 Aug 05; 255():12-22. PubMed ID: 26718876
    [Abstract] [Full Text] [Related]

  • 18. A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.
    Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water B, Price LS.
    Arch Toxicol; 2014 May 05; 88(5):1083-95. PubMed ID: 24599296
    [Abstract] [Full Text] [Related]

  • 19. Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure.
    Mueller D, Müller-Vieira U, Biemel KM, Tascher G, Nüssler AK, Noor F.
    Eur J Pharm Sci; 2012 Apr 11; 45(5):716-24. PubMed ID: 22330146
    [Abstract] [Full Text] [Related]

  • 20. Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.
    Ware BR, Berger DR, Khetani SR.
    Toxicol Sci; 2015 Jun 11; 145(2):252-62. PubMed ID: 25716675
    [Abstract] [Full Text] [Related]

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