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Journal Abstract Search

169 related items for PubMed ID: 23360470

  • 1. PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.
    Holmstock N, Gonzalez FJ, Baes M, Annaert P, Augustijns P.
    Mol Pharm; 2013 Mar 04; 10(3):1056-62. PubMed ID: 23360470
    [Abstract] [Full Text] [Related]

  • 2. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
    Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ.
    Drug Metab Dispos; 2008 Dec 04; 36(12):2506-12. PubMed ID: 18799805
    [Abstract] [Full Text] [Related]

  • 3. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
    Gupta A, Mugundu GM, Desai PB, Thummel KE, Unadkat JD.
    Drug Metab Dispos; 2008 Jun 04; 36(6):1172-80. PubMed ID: 18332086
    [Abstract] [Full Text] [Related]

  • 4. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
    Tan H, Xu C, Zeng H, Wang Y, Li Y, Fan X, Chen P, Jiang Y, Chen X, Huang M, Bi H.
    J Pharmacol Sci; 2016 Feb 04; 130(2):66-71. PubMed ID: 26782648
    [Abstract] [Full Text] [Related]

  • 5. Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells.
    Fan J, Maeng HJ, Du Y, Kwan D, Pang KS.
    Eur J Pharm Sci; 2011 Jan 18; 42(1-2):19-29. PubMed ID: 20955791
    [Abstract] [Full Text] [Related]

  • 6. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE, Simmermacher J, Dulac HA, Pizzano J, Sinz M.
    Drug Metab Dispos; 2010 Jan 18; 38(1):16-24. PubMed ID: 19833845
    [Abstract] [Full Text] [Related]

  • 7. Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
    Cheng J, Ma X, Gonzalez FJ.
    Br J Pharmacol; 2011 Jun 18; 163(3):461-8. PubMed ID: 21091656
    [Abstract] [Full Text] [Related]

  • 8. Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.
    Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.
    Drug Metab Dispos; 2012 Mar 18; 40(3):474-80. PubMed ID: 22126990
    [Abstract] [Full Text] [Related]

  • 9. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
    Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ.
    Drug Metab Dispos; 2009 Aug 18; 37(8):1611-21. PubMed ID: 19460945
    [Abstract] [Full Text] [Related]

  • 10. Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.
    MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR.
    Cancer Res; 2015 Nov 01; 75(21):4573-81. PubMed ID: 26363009
    [Abstract] [Full Text] [Related]

  • 11. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
    Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P.
    Drug Metab Dispos; 2008 Feb 01; 36(2):339-48. PubMed ID: 17998298
    [Abstract] [Full Text] [Related]

  • 12. Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.
    Liu CL, Lim YP, Hu ML.
    Mar Drugs; 2012 Jan 01; 10(1):242-257. PubMed ID: 22363234
    [Abstract] [Full Text] [Related]

  • 13. Essential oils of culinary herbs and spices activate PXR and induce CYP3A4 in human intestinal and hepatic in vitro models.
    Bartonkova I, Dvorak Z.
    Toxicol Lett; 2018 Oct 15; 296():1-9. PubMed ID: 30071242
    [Abstract] [Full Text] [Related]

  • 14. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
    Song X, Xie M, Zhang H, Li Y, Sachdeva K, Yan B.
    Drug Metab Dispos; 2004 Jan 15; 32(1):35-42. PubMed ID: 14709618
    [Abstract] [Full Text] [Related]

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  • 16. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
    Cummins CL, Jacobsen W, Benet LZ.
    J Pharmacol Exp Ther; 2002 Mar 15; 300(3):1036-45. PubMed ID: 11861813
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  • 18. CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
    Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.
    Mol Pharmacol; 2019 Nov 15; 96(5):600-608. PubMed ID: 31455676
    [Abstract] [Full Text] [Related]

  • 19. Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice.
    Yamasaki Y, Kobayashi K, Inaba A, Uehara D, Tojima H, Kakizaki S, Chiba K.
    Xenobiotica; 2018 Nov 15; 48(11):1098-1105. PubMed ID: 29095659
    [Abstract] [Full Text] [Related]

  • 20. Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells.
    Weiss J, Theile D, Spalwisz A, Burhenne J, Riedel KD, Haefeli WE.
    Biochem Pharmacol; 2013 Jan 15; 85(2):265-73. PubMed ID: 23219525
    [Abstract] [Full Text] [Related]

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