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PUBMED FOR HANDHELDS

Journal Abstract Search

267 related items for PubMed ID: 23434029

  • 1. Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.
    Chae E, Shin YJ, Ryu EJ, Ji MK, Ryune Cho N, Lee KH, Jeong HJ, Kim SJ, Choi Y, Seok Oh K, Park CE, Soo Yoon Y.
    Bioorg Med Chem Lett; 2013 Apr 01; 23(7):2134-9. PubMed ID: 23434029
    [Abstract] [Full Text] [Related]

  • 2. Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
    Anighoro A, Graziani D, Bettinelli I, Cilia A, De Toma C, Longhi M, Mangiarotti F, Menegon S, Pirona L, Poggesi E, Riva C, Rastelli G.
    Bioorg Med Chem; 2015 Jul 01; 23(13):3040-58. PubMed ID: 26014480
    [Abstract] [Full Text] [Related]

  • 3. 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
    Weiss JM, Jimenez HN, Li G, April M, Uberti MA, Bacolod MD, Brodbeck RM, Doller D.
    Bioorg Med Chem Lett; 2011 Aug 15; 21(16):4891-9. PubMed ID: 21757343
    [Abstract] [Full Text] [Related]

  • 4. Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
    Wágner G, Wéber C, Nyéki O, Nógrádi K, Bielik A, Molnár L, Bobok A, Horváth A, Kiss B, Kolok S, Nagy J, Kurkó D, Gál K, Greiner I, Szombathelyi Z, Keseru GM, Domány G.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3737-41. PubMed ID: 20483612
    [Abstract] [Full Text] [Related]

  • 5. Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.
    Zhou H, Topiol SW, Grenon M, Jimenez HN, Uberti MA, Smith DG, Brodbeck RM, Chandrasena G, Pedersen H, Madsen JC, Doller D, Li G.
    Bioorg Med Chem Lett; 2013 Mar 01; 23(5):1398-406. PubMed ID: 23357634
    [Abstract] [Full Text] [Related]

  • 6. Recent progress in the discovery and development of negative allosteric modulators of mGluR5.
    Lindsley CW, Emmitte KA.
    Curr Opin Drug Discov Devel; 2009 Jul 01; 12(4):446-57. PubMed ID: 19562641
    [Abstract] [Full Text] [Related]

  • 7. 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Xiong H, Brugel TA, Balestra M, Brown DG, Brush KA, Hightower C, Hinkley L, Hoesch V, Kang J, Koether GM, McCauley JP, McLaren FM, Panko LM, Simpson TR, Smith RW, Woods JM, Brockel B, Chhajlani V, Gadient RA, Spear N, Sygowski LA, Zhang M, Arora J, Breysse N, Wilson JM, Isaac M, Slassi A, King MM.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7381-4. PubMed ID: 21067920
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
    Kulkarni SS, Nightingale B, Dersch CM, Rothman RB, Newman AH.
    Bioorg Med Chem Lett; 2006 Jul 01; 16(13):3371-5. PubMed ID: 16678408
    [Abstract] [Full Text] [Related]

  • 9. A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.
    Duvey G, Perry B, Le Poul E, Poli S, Bonnet B, Lambeng N, Charvin D, Donovan-Rodrigues T, Haddouk H, Gagliardi S, Rocher JP.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4523-7. PubMed ID: 23850200
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
    Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, Brizzi A, Pasquini S, Allarà M, Fantini N, Carai MA, Bigogno C, Rozio MG, Sinisi R, Novellino E, Colombo G, Di Marzo V, Dondio G, Corelli F.
    Eur J Med Chem; 2010 Dec 15; 45(12):5878-86. PubMed ID: 20943290
    [Abstract] [Full Text] [Related]

  • 11. Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
    Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L.
    J Med Chem; 2015 Feb 12; 58(3):1358-71. PubMed ID: 25565255
    [Abstract] [Full Text] [Related]

  • 12. Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
    Sams AG, Mikkelsen GK, Brodbeck RM, Pu X, Ritzén A.
    Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3407-10. PubMed ID: 21531137
    [Abstract] [Full Text] [Related]

  • 13. Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
    Packiarajan M, Grenon M, Zorn S, Hopper AT, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.
    Bioorg Med Chem Lett; 2013 Jul 15; 23(14):4037-43. PubMed ID: 23770058
    [Abstract] [Full Text] [Related]

  • 14. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR.
    J Med Chem; 2004 Nov 18; 47(24):5825-8. PubMed ID: 15537338
    [Abstract] [Full Text] [Related]

  • 15. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous C, Vernier JM, Hutchinson JH, Chung J, Reyes-Manalo G, Kamenecka T.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1197-200. PubMed ID: 15686941
    [Abstract] [Full Text] [Related]

  • 16. N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.
    Felts AS, Rodriguez AL, Morrison RD, Venable DF, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.
    Bioorg Med Chem Lett; 2016 Apr 15; 26(8):1894-900. PubMed ID: 26988308
    [Abstract] [Full Text] [Related]

  • 17. Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
    Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4393-6. PubMed ID: 18614364
    [Abstract] [Full Text] [Related]

  • 18. CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.
    Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG.
    J Pharmacol Exp Ther; 2011 Nov 01; 339(2):474-86. PubMed ID: 21849627
    [Abstract] [Full Text] [Related]

  • 19. Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
    Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR.
    Bioorg Med Chem Lett; 2014 Aug 01; 24(15):3641-6. PubMed ID: 24961642
    [Abstract] [Full Text] [Related]

  • 20. Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
    Arsova A, Møller TC, Vedel L, Hansen JL, Foster SR, Gregory KJ, Bräuner-Osborne H.
    Mol Pharmacol; 2020 Jul 01; 98(1):49-60. PubMed ID: 32358164
    [Abstract] [Full Text] [Related]

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