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Journal Abstract Search

238 related items for PubMed ID: 2344370

  • 1. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
    Walton MI, Workman P.
    Biochem Pharmacol; 1990 Jun 01; 39(11):1735-42. PubMed ID: 2344370
    [Abstract] [Full Text] [Related]

  • 2. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Riley RJ, Hemingway SA, Graham MA, Workman P.
    Biochem Pharmacol; 1993 Mar 09; 45(5):1065-77. PubMed ID: 8461036
    [Abstract] [Full Text] [Related]

  • 3. The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
    Walton MI, Wolf CR, Workman P.
    Biochem Pharmacol; 1992 Jul 22; 44(2):251-9. PubMed ID: 1642640
    [Abstract] [Full Text] [Related]

  • 4. Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
    Walton MI, Wolf CR, Workman P.
    Int J Radiat Oncol Biol Phys; 1989 Apr 22; 16(4):983-6. PubMed ID: 2703406
    [Abstract] [Full Text] [Related]

  • 5. Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
    Riley RJ, Workman P.
    Biochem Pharmacol; 1992 Jan 22; 43(2):167-74. PubMed ID: 1739405
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
    Cahill A, Jenkins TC, White IN.
    Biochem Pharmacol; 1993 Jan 26; 45(2):321-9. PubMed ID: 7679576
    [Abstract] [Full Text] [Related]

  • 7. Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.
    Fitzsimmons SA, Lewis AD, Riley RJ, Workman P.
    Carcinogenesis; 1994 Aug 26; 15(8):1503-10. PubMed ID: 8055626
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  • 10. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    Walton MI, Workman P.
    J Pharmacol Exp Ther; 1993 May 26; 265(2):938-47. PubMed ID: 8496834
    [Abstract] [Full Text] [Related]

  • 11. The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
    Walton MI, Sugget N, Workman P.
    Int J Radiat Oncol Biol Phys; 1992 May 26; 22(4):643-7. PubMed ID: 1544831
    [Abstract] [Full Text] [Related]

  • 12. Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
    Silva JM, O'Brien PJ.
    Br J Cancer; 1993 Sep 26; 68(3):484-91. PubMed ID: 8394729
    [Abstract] [Full Text] [Related]

  • 13. Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro.
    Walton MI, Workman P.
    Biochem Pharmacol; 1987 Mar 15; 36(6):887-96. PubMed ID: 3105539
    [Abstract] [Full Text] [Related]

  • 14. Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
    Khan S, O'Brien PJ.
    Br J Cancer; 1995 Apr 15; 71(4):780-5. PubMed ID: 7710944
    [Abstract] [Full Text] [Related]

  • 15. p-nitrosophenol reduction by liver cytosol from ADH-positive and -negative deermice (Peromyscus maniculatus).
    Dudley BF, Winston GW.
    Arch Biochem Biophys; 1995 Feb 01; 316(2):879-85. PubMed ID: 7532387
    [Abstract] [Full Text] [Related]

  • 16. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 17. Metabolism of tirapazamine by multiple reductases in the nucleus.
    Delahoussaye YM, Evans JW, Brown JM.
    Biochem Pharmacol; 2001 Nov 01; 62(9):1201-9. PubMed ID: 11705453
    [Abstract] [Full Text] [Related]

  • 18. NAD (P) H-dependent reduction of nicotinamide N-oxide by an unique enzyme system consisting of liver microsomal NADPH-cytochrome C reductase and cytosolic aldehyde oxidase.
    Kitamura S, Wada Y, Tatsumi K.
    Biochem Biophys Res Commun; 1984 Dec 28; 125(3):1117-22. PubMed ID: 6240269
    [Abstract] [Full Text] [Related]

  • 19. The enzymology of doxorubicin quinone reduction in tumour tissue.
    Cummings J, Allan L, Willmott N, Riley R, Workman P, Smyth JF.
    Biochem Pharmacol; 1992 Dec 01; 44(11):2175-83. PubMed ID: 1472082
    [Abstract] [Full Text] [Related]

  • 20. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 01; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

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