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492 related items for PubMed ID: 23449454

  • 1. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
    Qi XF, Zheng L, Lee KJ, Kim DH, Kim CS, Cai DQ, Wu Z, Qin JW, Yu YH, Kim SK.
    Cell Death Dis; 2013 Feb 28; 4(2):e518. PubMed ID: 23449454
    [Abstract] [Full Text] [Related]

  • 2. Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin.
    Qi XF, Kim DH, Lee KJ, Kim CS, Song SB, Cai DQ, Kim SK.
    Cancer Cell Int; 2013 Nov 08; 13(1):111. PubMed ID: 24209962
    [Abstract] [Full Text] [Related]

  • 3. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.
    Blanco-Colio LM, Villa A, Ortego M, Hernández-Presa MA, Pascual A, Plaza JJ, Egido J.
    Atherosclerosis; 2002 Mar 08; 161(1):17-26. PubMed ID: 11882313
    [Abstract] [Full Text] [Related]

  • 4. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways.
    Chen JC, Huang KC, Lin WW.
    Cell Signal; 2006 Jan 08; 18(1):32-9. PubMed ID: 16214041
    [Abstract] [Full Text] [Related]

  • 5. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
    Tanaka T, Tatsuno I, Uchida D, Moroo I, Morio H, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Saito Y, Hirai A.
    J Neurosci; 2000 Apr 15; 20(8):2852-9. PubMed ID: 10751437
    [Abstract] [Full Text] [Related]

  • 6. Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.
    Demyanets S, Kaun C, Pfaffenberger S, Hohensinner PJ, Rega G, Pammer J, Maurer G, Huber K, Wojta J.
    Biochem Pharmacol; 2006 Apr 28; 71(9):1324-30. PubMed ID: 16540096
    [Abstract] [Full Text] [Related]

  • 7. Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.
    Wang T, Seah S, Loh X, Chan CW, Hartman M, Goh BC, Lee SC.
    Oncotarget; 2016 Jan 19; 7(3):2532-44. PubMed ID: 26565813
    [Abstract] [Full Text] [Related]

  • 8. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma.
    Yanae M, Tsubaki M, Satou T, Itoh T, Imano M, Yamazoe Y, Nishida S.
    J Exp Clin Cancer Res; 2011 Aug 10; 30(1):74. PubMed ID: 21831290
    [Abstract] [Full Text] [Related]

  • 9. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways.
    Kotamraju S, Williams CL, Kalyanaraman B.
    Cancer Res; 2007 Aug 01; 67(15):7386-94. PubMed ID: 17671209
    [Abstract] [Full Text] [Related]

  • 10. The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase.
    Maciejak A, Leszczynska A, Warchol I, Gora M, Kaminska J, Plochocka D, Wysocka-Kapcinska M, Tulacz D, Siedlecka J, Swiezewska E, Sojka M, Danikiewicz W, Odolczyk N, Szkopinska A, Sygitowicz G, Burzynska B.
    BMC Biotechnol; 2013 Aug 30; 13():68. PubMed ID: 24128347
    [Abstract] [Full Text] [Related]

  • 11. Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.
    Kubota T, Fujisaki K, Itoh Y, Yano T, Sendo T, Oishi R.
    Biochem Pharmacol; 2004 Jun 15; 67(12):2175-86. PubMed ID: 15163549
    [Abstract] [Full Text] [Related]

  • 12. Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells.
    Tsubaki M, Mashimo K, Takeda T, Kino T, Fujita A, Itoh T, Imano M, Sakaguchi K, Satou T, Nishida S.
    Biomed Pharmacother; 2016 Mar 15; 78():23-29. PubMed ID: 26898421
    [Abstract] [Full Text] [Related]

  • 13. Statins induce differentiation and cell death in neurons and astroglia.
    März P, Otten U, Miserez AR.
    Glia; 2007 Jan 01; 55(1):1-12. PubMed ID: 16998865
    [Abstract] [Full Text] [Related]

  • 14. Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.
    Ghavami S, Mutawe MM, Hauff K, Stelmack GL, Schaafsma D, Sharma P, McNeill KD, Hynes TS, Kung SK, Unruh H, Klonisch T, Hatch GM, Los M, Halayko AJ.
    Biochim Biophys Acta; 2010 Apr 01; 1803(4):452-67. PubMed ID: 20045437
    [Abstract] [Full Text] [Related]

  • 15. Deltonin induces apoptosis in MDA‑MB‑231 human breast cancer cells via reactive oxygen species‑mediated mitochondrial dysfunction and ERK/AKT signaling pathways.
    Zhang S, He Y, Tong Q, Chen Q, Wu X, Huang W.
    Mol Med Rep; 2013 Mar 01; 7(3):1038-44. PubMed ID: 23314115
    [Abstract] [Full Text] [Related]

  • 16. Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals.
    Shu D, Qing Y, Tong Q, He Y, Xing Z, Zhao Y, Li Y, Wei Y, Huang W, Wu X.
    Biol Pharm Bull; 2011 Mar 01; 34(8):1231-9. PubMed ID: 21804211
    [Abstract] [Full Text] [Related]

  • 17. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
    Gbelcová H, Rimpelová S, Knejzlík Z, Šáchová J, Kolář M, Strnad H, Repiská V, D'Acunto WC, Ruml T, Vítek L.
    Lipids Health Dis; 2017 Dec 20; 16(1):250. PubMed ID: 29262834
    [Abstract] [Full Text] [Related]

  • 18. Toxicity of statins on rat skeletal muscle mitochondria.
    Kaufmann P, Török M, Zahno A, Waldhauser KM, Brecht K, Krähenbühl S.
    Cell Mol Life Sci; 2006 Oct 20; 63(19-20):2415-25. PubMed ID: 17013560
    [Abstract] [Full Text] [Related]

  • 19. Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways.
    Ho SY, Wu WJ, Chiu HW, Chen YA, Ho YS, Guo HR, Wang YJ.
    Chem Biol Interact; 2011 Sep 05; 193(2):162-71. PubMed ID: 21741957
    [Abstract] [Full Text] [Related]

  • 20. Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
    Ravindran J, Gupta N, Agrawal M, Bala Bhaskar AS, Lakshmana Rao PV.
    Apoptosis; 2011 Feb 05; 16(2):145-61. PubMed ID: 21082355
    [Abstract] [Full Text] [Related]

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