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PUBMED FOR HANDHELDS

Journal Abstract Search


271 related items for PubMed ID: 23454189

  • 1. PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.
    Caruso A, Alvarez-Sánchez R, Hillebrecht A, Poirier A, Schuler F, Lavé T, Funk C, Belli S.
    Biochem Pharmacol; 2013 Jun 01; 85(11):1684-99. PubMed ID: 23454189
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  • 3. Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure.
    He H, Lyons KA, Shen X, Yao Z, Bleasby K, Chan G, Hafey M, Li X, Xu S, Salituro GM, Cohen LH, Tang W.
    Xenobiotica; 2009 Sep 01; 39(9):687-93. PubMed ID: 19569734
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  • 5. Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.
    Mariappan TT, Kurawattimath V, Gautam SS, Kulkarni CP, Kallem R, Taskar KS, Marathe PH, Mandlekar S.
    Mol Pharm; 2014 Feb 03; 11(2):477-85. PubMed ID: 24380373
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  • 13. Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.
    Shen DD, Artru AA, Adkison KK.
    Adv Drug Deliv Rev; 2004 Oct 14; 56(12):1825-57. PubMed ID: 15381336
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  • 14. In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
    Hsiao P, Bui T, Ho RJ, Unadkat JD.
    Drug Metab Dispos; 2008 Mar 14; 36(3):481-4. PubMed ID: 18057117
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  • 16. Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.
    Zhang YY, Liu H, Summerfield SG, Luscombe CN, Sahi J.
    Mol Pharm; 2016 May 02; 13(5):1540-50. PubMed ID: 27015243
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  • 17. In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms.
    Chen H, Winiwarter S, Fridén M, Antonsson M, Engkvist O.
    J Mol Graph Model; 2011 Aug 02; 29(8):985-95. PubMed ID: 21571561
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  • 19. Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats.
    Nagaya Y, Nozaki Y, Takenaka O, Watari R, Kusano K, Yoshimura T, Kusuhara H.
    Drug Metab Pharmacokinet; 2016 Feb 02; 31(1):57-66. PubMed ID: 26830080
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