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Journal Abstract Search

192 related items for PubMed ID: 23460019

  • 1. Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.
    Wiza C, Herzfeld de Wiza D, Nascimento EB, Lehr S, Al-Hasani H, Ouwens DM.
    Diabetologia; 2013 May; 56(5):1118-28. PubMed ID: 23460019
    [Abstract] [Full Text] [Related]

  • 2. Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.
    Wiza C, Chadt A, Blumensatt M, Kanzleiter T, Herzfeld De Wiza D, Horrighs A, Mueller H, Nascimento EB, Schürmann A, Al-Hasani H, Ouwens DM.
    Arch Physiol Biochem; 2014 May; 120(2):64-72. PubMed ID: 24576065
    [Abstract] [Full Text] [Related]

  • 3. Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
    Nascimento EB, Snel M, Guigas B, van der Zon GC, Kriek J, Maassen JA, Jazet IM, Diamant M, Ouwens DM.
    Cell Signal; 2010 Jun; 22(6):961-7. PubMed ID: 20138985
    [Abstract] [Full Text] [Related]

  • 4. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
    Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.
    J Biol Chem; 2011 Nov 04; 286(44):38043-38053. PubMed ID: 21914810
    [Abstract] [Full Text] [Related]

  • 5. Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.
    Joassard OR, Amirouche A, Gallot YS, Desgeorges MM, Castells J, Durieux AC, Berthon P, Freyssenet DG.
    Int J Biochem Cell Biol; 2013 Nov 04; 45(11):2444-55. PubMed ID: 23916784
    [Abstract] [Full Text] [Related]

  • 6. Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.
    Wang H, Zhang Q, Wen Q, Zheng Y, Lazarovici P, Jiang H, Lin J, Zheng W.
    Cell Signal; 2012 Jan 04; 24(1):17-24. PubMed ID: 21906675
    [Abstract] [Full Text] [Related]

  • 7. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression.
    Maity S, Das F, Kasinath BS, Ghosh-Choudhury N, Ghosh Choudhury G.
    J Biol Chem; 2020 Oct 16; 295(42):14262-14278. PubMed ID: 32732288
    [Abstract] [Full Text] [Related]

  • 8. Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
    Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Mühlich S, Pfeiffer AFH, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A.
    Cell Signal; 2014 Feb 16; 26(2):233-239. PubMed ID: 24219910
    [Abstract] [Full Text] [Related]

  • 9. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes.
    Kirk-Ballard H, Wang ZQ, Acharya P, Zhang XH, Yu Y, Kilroy G, Ribnicky D, Cefalu WT, Floyd ZE.
    PLoS One; 2013 Feb 16; 8(2):e57112. PubMed ID: 23437325
    [Abstract] [Full Text] [Related]

  • 10. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
    Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.
    Nat Cell Biol; 2007 Mar 16; 9(3):316-23. PubMed ID: 17277771
    [Abstract] [Full Text] [Related]

  • 11. Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture.
    Vandanmagsar B, Haynie KR, Wicks SE, Bermudez EM, Mendoza TM, Ribnicky D, Cefalu WT, Mynatt RL.
    Diabetes Obes Metab; 2014 Aug 16; 16(8):728-38. PubMed ID: 24521217
    [Abstract] [Full Text] [Related]

  • 12. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.
    J Biol Chem; 2007 Jul 13; 282(28):20329-39. PubMed ID: 17517883
    [Abstract] [Full Text] [Related]

  • 13. Over-expression of NYGGF4 (PID1) inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway.
    Wu WL, Gan WH, Tong ML, Li XL, Dai JZ, Zhang CM, Guo XR.
    Mol Genet Metab; 2011 Mar 13; 102(3):374-7. PubMed ID: 21185755
    [Abstract] [Full Text] [Related]

  • 14. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
    Lee A, Hakuno F, Northcott P, Pessin JE, Rozakis Adcock M.
    PLoS One; 2013 Mar 13; 8(1):e55634. PubMed ID: 23383252
    [Abstract] [Full Text] [Related]

  • 15. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
    Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ.
    Am J Physiol Cell Physiol; 2009 Jun 13; 296(6):C1258-70. PubMed ID: 19357233
    [Abstract] [Full Text] [Related]

  • 16. AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis.
    Mi W, Ye Q, Liu S, She QB.
    Oncotarget; 2015 Jun 10; 6(16):13962-77. PubMed ID: 25961827
    [Abstract] [Full Text] [Related]

  • 17. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.
    Zhang L, Kimball SR, Jefferson LS, Shenberger JS.
    Free Radic Biol Med; 2009 Jun 01; 46(11):1500-9. PubMed ID: 19281842
    [Abstract] [Full Text] [Related]

  • 18. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.
    Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A.
    Diabetes; 2008 Aug 01; 57(8):2066-73. PubMed ID: 18443205
    [Abstract] [Full Text] [Related]

  • 19. A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.
    Lai YC, Liu Y, Jacobs R, Rider MH.
    Biochem J; 2012 Oct 01; 447(1):137-47. PubMed ID: 22793019
    [Abstract] [Full Text] [Related]

  • 20. Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway.
    Geetha T, Langlais P, Caruso M, Yi Z.
    J Endocrinol; 2012 Sep 01; 214(3):437-43. PubMed ID: 22728334
    [Abstract] [Full Text] [Related]

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