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137 related items for PubMed ID: 23468426

  • 1. The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
    Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2013 Mar 18; 14(5):599-606. PubMed ID: 23468426
    [Abstract] [Full Text] [Related]

  • 2. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
    Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ.
    Biochemistry; 2005 May 03; 44(17):6619-28. PubMed ID: 15850395
    [Abstract] [Full Text] [Related]

  • 3. The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
    Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.
    Arch Biochem Biophys; 2013 Feb 01; 530(1):48-53. PubMed ID: 23262315
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  • 5. The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
    Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.
    Arch Biochem Biophys; 2011 Dec 15; 516(2):103-7. PubMed ID: 22001738
    [Abstract] [Full Text] [Related]

  • 6. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
    Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ.
    Biochem J; 2003 Jun 15; 372(Pt 3):687-93. PubMed ID: 12622704
    [Abstract] [Full Text] [Related]

  • 7. Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
    Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    Biochem Biophys Res Commun; 2010 Aug 06; 398(4):659-64. PubMed ID: 20603104
    [Abstract] [Full Text] [Related]

  • 8. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.
    Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.
    FEBS Lett; 2013 Aug 19; 587(16):2705-9. PubMed ID: 23860486
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  • 10. Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
    Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2009 Aug 17; 10(12):2025-31. PubMed ID: 19598184
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  • 11. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
    Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE.
    Nature; 1997 Jun 19; 387(6635):827-30. PubMed ID: 9194566
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  • 12. The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.
    Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE.
    Nature; 1999 Oct 14; 401(6754):721-4. PubMed ID: 10537113
    [Abstract] [Full Text] [Related]

  • 13. A heuristic approach to the analysis of enzymic catalysis: reaction of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes.
    Blackburn JM, Sutherland JD, Baldwin JE.
    Biochemistry; 1995 Jun 06; 34(22):7548-62. PubMed ID: 7779800
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  • 15. Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.
    Elkins JM, Rutledge PJ, Burzlaff NI, Clifton IJ, Adlington RM, Roach PL, Baldwin JE.
    Org Biomol Chem; 2003 May 07; 1(9):1455-60. PubMed ID: 12926272
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  • 16. Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
    McNeill LA, Brown TJN, Sami M, Clifton IJ, Burzlaff NI, Claridge TDW, Adlington RM, Baldwin JE, Rutledge PJ, Schofield CJ.
    Chemistry; 2017 Sep 18; 23(52):12815-12824. PubMed ID: 28703303
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  • 18. Isopenicillin N Synthase: Crystallographic Studies.
    Chapman NC, Rutledge PJ.
    Chembiochem; 2021 May 14; 22(10):1687-1705. PubMed ID: 33415840
    [Abstract] [Full Text] [Related]

  • 19. Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase.
    Rabe P, Walla CC, Goodyear NK, Welsh J, Southwart R, Clifton I, Linyard JDS, Tumber A, Claridge TDW, Myers WK, Schofield CJ.
    J Biol Chem; 2022 Sep 14; 298(9):102249. PubMed ID: 35835215
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  • 20. Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?
    Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    J Am Chem Soc; 2008 Aug 06; 130(31):10096-102. PubMed ID: 18620394
    [Abstract] [Full Text] [Related]

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