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Journal Abstract Search

277 related items for PubMed ID: 23485065

  • 21. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
    DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK.
    Nature; 2016 Jul 07; 535(7610):182-6. PubMed ID: 27362234
    [Abstract] [Full Text] [Related]

  • 22. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.
    Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S.
    J Biol Chem; 2013 Jun 14; 288(24):17167-78. PubMed ID: 23629648
    [Abstract] [Full Text] [Related]

  • 23. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
    Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK.
    Nature; 2011 Jan 13; 469(7329):175-80. PubMed ID: 21228869
    [Abstract] [Full Text] [Related]

  • 24. Search for β2 adrenergic receptor ligands by virtual screening via grid computing and investigation of binding modes by docking and molecular dynamics simulations.
    Bai Q, Shao Y, Pan D, Zhang Y, Liu H, Yao X.
    PLoS One; 2014 Jan 13; 9(9):e107837. PubMed ID: 25229694
    [Abstract] [Full Text] [Related]

  • 25. Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.
    Reynolds KA, Katritch V, Abagyan R.
    J Comput Aided Mol Des; 2009 May 13; 23(5):273-88. PubMed ID: 19148767
    [Abstract] [Full Text] [Related]

  • 26. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.
    Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK.
    Nature; 2017 Aug 24; 548(7668):480-484. PubMed ID: 28813418
    [Abstract] [Full Text] [Related]

  • 27. The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays.
    Schneider M, Wolf S, Schlitter J, Gerwert K.
    FEBS Lett; 2011 Nov 16; 585(22):3587-92. PubMed ID: 22027616
    [Abstract] [Full Text] [Related]

  • 28. An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
    Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P.
    Nat Chem Biol; 2020 Jul 16; 16(7):749-755. PubMed ID: 32483378
    [Abstract] [Full Text] [Related]

  • 29. Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation.
    Zhu Y, Yuan Y, Xiao X, Zhang L, Guo Y, Pu X.
    J Mol Model; 2014 Nov 16; 20(11):2491. PubMed ID: 25342155
    [Abstract] [Full Text] [Related]

  • 30. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
    Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.
    Proc Natl Acad Sci U S A; 2017 Feb 14; 114(7):1708-1713. PubMed ID: 28130548
    [Abstract] [Full Text] [Related]

  • 31. Function-specific virtual screening for GPCR ligands using a combined scoring method.
    Kooistra AJ, Vischer HF, McNaught-Flores D, Leurs R, de Esch IJ, de Graaf C.
    Sci Rep; 2016 Jun 24; 6():28288. PubMed ID: 27339552
    [Abstract] [Full Text] [Related]

  • 32. Development and characterization of pepducins as Gs-biased allosteric agonists.
    Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JL.
    J Biol Chem; 2014 Dec 26; 289(52):35668-84. PubMed ID: 25395624
    [Abstract] [Full Text] [Related]

  • 33.
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  • 34. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
    Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.
    Science; 2007 Nov 23; 318(5854):1266-73. PubMed ID: 17962519
    [Abstract] [Full Text] [Related]

  • 35. β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.
    Kim D, Pauer SH, Yong HM, An SS, Liggett SB.
    J Biol Chem; 2016 Aug 19; 291(34):17616-28. PubMed ID: 27342779
    [Abstract] [Full Text] [Related]

  • 36.
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  • 37. Structure-based discovery of beta2-adrenergic receptor ligands.
    Kolb P, Rosenbaum DM, Irwin JJ, Fung JJ, Kobilka BK, Shoichet BK.
    Proc Natl Acad Sci U S A; 2009 Apr 21; 106(16):6843-8. PubMed ID: 19342484
    [Abstract] [Full Text] [Related]

  • 38. A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.
    Sanchez-Soto M, Verma RK, Willette BKA, Gonye EC, Moore AM, Moritz AE, Boateng CA, Yano H, Free RB, Shi L, Sibley DR.
    Sci Signal; 2020 Feb 04; 13(617):. PubMed ID: 32019899
    [Abstract] [Full Text] [Related]

  • 39. Cell-based high-throughput screening assay system for monitoring G protein-coupled receptor activation using beta-galactosidase enzyme complementation technology.
    Yan YX, Boldt-Houle DM, Tillotson BP, Gee MA, D'Eon BJ, Chang XJ, Olesen CE, Palmer MA.
    J Biomol Screen; 2002 Oct 04; 7(5):451-9. PubMed ID: 14599361
    [Abstract] [Full Text] [Related]

  • 40. Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.
    Dalton JA, Lans I, Giraldo J.
    BMC Bioinformatics; 2015 Apr 23; 16(1):124. PubMed ID: 25902715
    [Abstract] [Full Text] [Related]

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