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211 related items for PubMed ID: 23512348

  • 1. Obscurins: unassuming giants enter the spotlight.
    Perry NA, Ackermann MA, Shriver M, Hu LY, Kontrogianni-Konstantopoulos A.
    IUBMB Life; 2013 Jun; 65(6):479-86. PubMed ID: 23512348
    [Abstract] [Full Text] [Related]

  • 2. Obscurins: Goliaths and Davids take over non-muscle tissues.
    Ackermann MA, Shriver M, Perry NA, Hu LY, Kontrogianni-Konstantopoulos A.
    PLoS One; 2014 Jun; 9(2):e88162. PubMed ID: 24516603
    [Abstract] [Full Text] [Related]

  • 3. Unraveling obscurins in heart disease.
    Grogan A, Kontrogianni-Konstantopoulos A.
    Pflugers Arch; 2019 May; 471(5):735-743. PubMed ID: 30099631
    [Abstract] [Full Text] [Related]

  • 4. Obscure functions: the location-function relationship of obscurins.
    Manring HR, Carter OA, Ackermann MA.
    Biophys Rev; 2017 Jun; 9(3):245-258. PubMed ID: 28510116
    [Abstract] [Full Text] [Related]

  • 5. Obscurin: A multitasking giant in the fight against cancer.
    Guardia T, Eason M, Kontrogianni-Konstantopoulos A.
    Biochim Biophys Acta Rev Cancer; 2021 Aug; 1876(1):188567. PubMed ID: 34015411
    [Abstract] [Full Text] [Related]

  • 6. Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance.
    Perry NA, Shriver M, Mameza MG, Grabias B, Balzer E, Kontrogianni-Konstantopoulos A.
    FASEB J; 2012 Jul; 26(7):2764-75. PubMed ID: 22441987
    [Abstract] [Full Text] [Related]

  • 7. Giant obscurin regulates migration and metastasis via RhoA-dependent cytoskeletal remodeling in pancreatic cancer.
    Tuntithavornwat S, Shea DJ, Wong BS, Guardia T, Lee SJ, Yankaskas CL, Zheng L, Kontrogianni-Konstantopoulos A, Konstantopoulos K.
    Cancer Lett; 2022 Feb 01; 526():155-167. PubMed ID: 34826548
    [Abstract] [Full Text] [Related]

  • 8. The kinase domains of obscurin interact with intercellular adhesion proteins.
    Hu LY, Kontrogianni-Konstantopoulos A.
    FASEB J; 2013 May 01; 27(5):2001-12. PubMed ID: 23392350
    [Abstract] [Full Text] [Related]

  • 9. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit.
    Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, Kontrogianni-Konstantopoulos A.
    Oncotarget; 2016 Jul 19; 7(29):45414-45428. PubMed ID: 27323778
    [Abstract] [Full Text] [Related]

  • 10. When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability.
    Fukuzawa A, Koch D, Grover S, Rees M, Gautel M.
    Hum Mol Genet; 2021 Jun 09; 30(12):1131-1141. PubMed ID: 33438037
    [Abstract] [Full Text] [Related]

  • 11. The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
    Ford-Speelman DL, Roche JA, Bowman AL, Bloch RJ.
    Mol Biol Cell; 2009 Sep 09; 20(17):3905-17. PubMed ID: 19605563
    [Abstract] [Full Text] [Related]

  • 12. Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
    Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O'Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A.
    Sci Adv; 2017 Jun 09; 3(6):e1603081. PubMed ID: 28630914
    [Abstract] [Full Text] [Related]

  • 13. The potential of obscurin as a therapeutic target in muscle disorders.
    Randazzo D, Pierantozzi E, Rossi D, Sorrentino V.
    Expert Opin Ther Targets; 2017 Sep 09; 21(9):897-910. PubMed ID: 28756711
    [Abstract] [Full Text] [Related]

  • 14. Novel OBSCN variants associated with a risk to exercise-intolerance and rhabdomyolysis.
    Zemorshidi F, Töpf A, Claeys KG, McFarlane A, Patton A, Nafissi S, Straub V.
    Neuromuscul Disord; 2024 Jan 09; 34():83-88. PubMed ID: 38159459
    [Abstract] [Full Text] [Related]

  • 15. Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.
    Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A.
    Oncogene; 2015 Aug 06; 34(32):4248-59. PubMed ID: 25381817
    [Abstract] [Full Text] [Related]

  • 16. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly.
    Young P, Ehler E, Gautel M.
    J Cell Biol; 2001 Jul 09; 154(1):123-36. PubMed ID: 11448995
    [Abstract] [Full Text] [Related]

  • 17. Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth.
    Borisov AB, Raeker MO, Kontrogianni-Konstantopoulos A, Yang K, Kurnit DM, Bloch RJ, Russell MW.
    Biochem Biophys Res Commun; 2003 Oct 24; 310(3):910-8. PubMed ID: 14550291
    [Abstract] [Full Text] [Related]

  • 18. Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells.
    Borisov AB, Raeker MO, Russell MW.
    J Cell Biochem; 2008 Apr 01; 103(5):1621-35. PubMed ID: 18041765
    [Abstract] [Full Text] [Related]

  • 19. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.
    Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S.
    Commun Biol; 2019 Apr 01; 2():178. PubMed ID: 31098411
    [Abstract] [Full Text] [Related]

  • 20. Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.
    Sutter SB, Raeker MO, Borisov AB, Russell MW.
    Dev Genes Evol; 2004 Jul 01; 214(7):352-9. PubMed ID: 15185077
    [Abstract] [Full Text] [Related]

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