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337 related items for PubMed ID: 2353935

  • 1. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
    Bai R, Pettit GR, Hamel E.
    Biochem Pharmacol; 1990 Jun 15; 39(12):1941-9. PubMed ID: 2353935
    [Abstract] [Full Text] [Related]

  • 2. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
    Bai RL, Pettit GR, Hamel E.
    J Biol Chem; 1990 Oct 05; 265(28):17141-9. PubMed ID: 2211617
    [Abstract] [Full Text] [Related]

  • 3. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
    Bai R, Friedman SJ, Pettit GR, Hamel E.
    Biochem Pharmacol; 1992 Jun 23; 43(12):2637-45. PubMed ID: 1632820
    [Abstract] [Full Text] [Related]

  • 4. Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.
    Li Y, Kobayashi H, Hashimoto Y, Shirai R, Hirata A, Hayashi K, Hamada Y, Shioiri T, Iwasaki S.
    Chem Biol Interact; 1994 Dec 23; 93(3):175-83. PubMed ID: 7923438
    [Abstract] [Full Text] [Related]

  • 5. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
    Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E.
    J Biol Chem; 1991 Aug 25; 266(24):15882-9. PubMed ID: 1874739
    [Abstract] [Full Text] [Related]

  • 6. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.
    Biochemistry; 1995 Aug 01; 34(30):9714-21. PubMed ID: 7626642
    [Abstract] [Full Text] [Related]

  • 7. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.
    Hamel E.
    Pharmacol Ther; 1992 Aug 01; 55(1):31-51. PubMed ID: 1287674
    [Abstract] [Full Text] [Related]

  • 8. Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.
    Natsume T, Watanabe J, Tamaoki S, Fujio N, Miyasaka K, Kobayashi M.
    Jpn J Cancer Res; 2000 Jul 01; 91(7):737-47. PubMed ID: 10920282
    [Abstract] [Full Text] [Related]

  • 9. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
    Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.
    Mol Pharmacol; 1993 Oct 01; 44(4):757-66. PubMed ID: 8232226
    [Abstract] [Full Text] [Related]

  • 10. Interaction of ustiloxin A with bovine brain tubulin.
    Ludueńa RF, Roach MC, Prasad V, Banerjee M, Koiso Y, Li Y, Iwasaki S.
    Biochem Pharmacol; 1994 Apr 29; 47(9):1593-9. PubMed ID: 8185673
    [Abstract] [Full Text] [Related]

  • 11. Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
    Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E.
    Biochem Pharmacol; 1993 Apr 06; 45(7):1503-15. PubMed ID: 8471072
    [Abstract] [Full Text] [Related]

  • 12. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
    Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E.
    Eur J Biochem; 2003 Sep 06; 270(18):3822-8. PubMed ID: 12950266
    [Abstract] [Full Text] [Related]

  • 13. Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
    Bai RL, Pettit GR, Hamel E.
    Biochem Pharmacol; 1990 Oct 15; 40(8):1859-64. PubMed ID: 2242019
    [Abstract] [Full Text] [Related]

  • 14. Effects of antimitotic agents on tubulin-nucleotide interactions.
    Correia JJ.
    Pharmacol Ther; 1991 Nov 15; 52(2):127-47. PubMed ID: 1818332
    [Abstract] [Full Text] [Related]

  • 15. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site.
    Li Y, Kobayashi H, Tokiwa Y, Hashimoto Y, Iwasaki S.
    Biochem Pharmacol; 1992 Jan 22; 43(2):219-24. PubMed ID: 1739410
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10.
    Edler MC, Fernandez AM, Lassota P, Ireland CM, Barrows LR.
    Biochem Pharmacol; 2002 Feb 15; 63(4):707-15. PubMed ID: 11992639
    [Abstract] [Full Text] [Related]

  • 17. Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
    Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E.
    Mol Pharmacol; 2003 Jun 15; 63(6):1273-80. PubMed ID: 12761336
    [Abstract] [Full Text] [Related]

  • 18. Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.
    Ludueña RF, Roach MC, Prasad V, Pettit GR.
    Biochem Pharmacol; 1993 Jan 26; 45(2):421-7. PubMed ID: 8435093
    [Abstract] [Full Text] [Related]

  • 19. Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid.
    Kruczynski A, Barret JM, Etiévant C, Colpaert F, Fahy J, Hill BT.
    Biochem Pharmacol; 1998 Mar 01; 55(5):635-48. PubMed ID: 9515574
    [Abstract] [Full Text] [Related]

  • 20. Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.
    Bai R, Durso NA, Sackett DL, Hamel E.
    Biochemistry; 1999 Oct 26; 38(43):14302-10. PubMed ID: 10572005
    [Abstract] [Full Text] [Related]

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