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Journal Abstract Search

182 related items for PubMed ID: 23541835

  • 1. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
    Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H.
    Bioorg Med Chem; 2013 May 01; 21(9):2568-76. PubMed ID: 23541835
    [Abstract] [Full Text] [Related]

  • 2. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.
    Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H.
    ChemMedChem; 2013 Nov 01; 8(11):1855-64. PubMed ID: 24039134
    [Abstract] [Full Text] [Related]

  • 3. Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
    Lacivita E, Patarnello D, Stroth N, Caroli A, Niso M, Contino M, De Giorgio P, Di Pilato P, Colabufo NA, Berardi F, Perrone R, Svenningsson P, Hedlund PB, Leopoldo M.
    J Med Chem; 2012 Jul 26; 55(14):6375-80. PubMed ID: 22738316
    [Abstract] [Full Text] [Related]

  • 4. New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
    Liao Y, Böttcher H, Harting J, Greiner H, van Amsterdam C, Cremers T, Sundell S, März J, Rautenberg W, Wikström H.
    J Med Chem; 2000 Feb 10; 43(3):517-25. PubMed ID: 10669578
    [Abstract] [Full Text] [Related]

  • 5. Novel quinazolinone derivatives as 5-HT7 receptor ligands.
    Na YH, Hong SH, Lee JH, Park WK, Baek DJ, Koh HY, Cho YS, Choo H, Pae AN.
    Bioorg Med Chem; 2008 Mar 01; 16(5):2570-8. PubMed ID: 18083580
    [Abstract] [Full Text] [Related]

  • 6. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ, Paluchowska MH, Duszyńska B, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2293-303. PubMed ID: 15727878
    [Abstract] [Full Text] [Related]

  • 7. 4-Aminoethylpiperazinyl aryl ketones with 5-HT₁A/5-HT₇ selectivity.
    Kim MK, Lee HS, Kim S, Cho SY, Roth BL, Chong Y, Choo H.
    Bioorg Med Chem; 2012 Jan 15; 20(2):1139-48. PubMed ID: 22196512
    [Abstract] [Full Text] [Related]

  • 8. Synthesis by microwave irradiation and binding properties of novel 5-HT(1A) receptor ligands.
    Caliendo G, Fiorino F, Perissutti E, Severino B, Gessi S, Cattabriga E, Borea PA, Santagada V.
    Eur J Med Chem; 2001 Jan 15; 36(11-12):873-86. PubMed ID: 11755230
    [Abstract] [Full Text] [Related]

  • 9. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

  • 10. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S, Kołaczkowski M, Maryniak E, Zajdel P, Pawłowski M, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Bojarski AJ, Charakchieva-Minol S, Duszyńska B, Nowak G, Maciag D.
    J Med Chem; 2004 May 06; 47(10):2659-66. PubMed ID: 15115407
    [Abstract] [Full Text] [Related]

  • 11. 5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity.
    Kim Y, Park H, Lee J, Tae J, Kim HJ, Min SJ, Rhim H, Choo H.
    Eur J Med Chem; 2016 Nov 10; 123():180-190. PubMed ID: 27475109
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
    Hirokawa Y, Fujiwara I, Suzuki K, Harada H, Yoshikawa T, Yoshida N, Kato S.
    J Med Chem; 2003 Feb 27; 46(5):702-15. PubMed ID: 12593651
    [Abstract] [Full Text] [Related]

  • 13. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
    Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A.
    J Med Chem; 1999 May 06; 42(9):1556-75. PubMed ID: 10229626
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
    Modica MN, Intagliata S, Pittalà V, Salerno L, Siracusa MA, Cagnotto A, Salmona M, Romeo G.
    Bioorg Med Chem Lett; 2015 Apr 01; 25(7):1427-30. PubMed ID: 25759032
    [Abstract] [Full Text] [Related]

  • 15. Modification of the structure of 4, 6-disubstituted 2-(4-alkyl-1-piperazinyl)pyridines: synthesis and their 5-HT2A receptor activity.
    Paluchowska MH, Bojarski AJ, Bugno R, Charakchieva-Minol S, Wesołowska A.
    Arch Pharm (Weinheim); 2003 Apr 01; 336(2):104-10. PubMed ID: 12761763
    [Abstract] [Full Text] [Related]

  • 16. 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators.
    Bernotas RC, Antane S, Shenoy R, Le VD, Chen P, Harrison BL, Robichaud AJ, Zhang GM, Smith D, Schechter LE.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1657-60. PubMed ID: 20138763
    [Abstract] [Full Text] [Related]

  • 17. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.
    Canale V, Guzik P, Kurczab R, Verdie P, Satała G, Kubica B, Pawłowski M, Martinez J, Subra G, Bojarski AJ, Zajdel P.
    Eur J Med Chem; 2014 May 06; 78():10-22. PubMed ID: 24675176
    [Abstract] [Full Text] [Related]

  • 18. Novel 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists.
    Elokdah H, Li D, McFarlane G, Bernotas RC, Robichaud AJ, Magolda RL, Zhang GM, Smith D, Schechter LE.
    Bioorg Med Chem; 2007 Sep 15; 15(18):6208-26. PubMed ID: 17624788
    [Abstract] [Full Text] [Related]

  • 19. Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.
    Volk B, Gacsályi I, Pallagi K, Poszávácz L, Gyönös I, Szabó E, Bakó T, Spedding M, Simig G, Szénási G.
    J Med Chem; 2011 Oct 13; 54(19):6657-69. PubMed ID: 21859099
    [Abstract] [Full Text] [Related]

  • 20. 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
    Chłoń-Rzepa G, Zmudzki P, Zajdel P, Bojarski AJ, Duszyńska B, Nikiforuk A, Tatarczyńska E, Pawłowski M.
    Bioorg Med Chem; 2007 Aug 01; 15(15):5239-50. PubMed ID: 17517514
    [Abstract] [Full Text] [Related]

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