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Journal Abstract Search

285 related items for PubMed ID: 23549429

  • 1. Discovery of Rho-kinase inhibitors by docking-based virtual screening.
    Shen M, Yu H, Li Y, Li P, Pan P, Zhou S, Zhang L, Li S, Lee SM, Hou T.
    Mol Biosyst; 2013 Jun; 9(6):1511-21. PubMed ID: 23549429
    [Abstract] [Full Text] [Related]

  • 2. Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays.
    Shen M, Tian S, Pan P, Sun H, Li D, Li Y, Zhou H, Li C, Lee SM, Hou T.
    Sci Rep; 2015 Nov 16; 5():16749. PubMed ID: 26568382
    [Abstract] [Full Text] [Related]

  • 3. Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.
    Shen M, Zhou S, Li Y, Pan P, Zhang L, Hou T.
    Mol Biosyst; 2013 Mar 16; 9(3):361-74. PubMed ID: 23340525
    [Abstract] [Full Text] [Related]

  • 4. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening.
    Chong CM, Kou MT, Pan P, Zhou H, Ai N, Li C, Zhong HJ, Leung CH, Hou T, Lee SM.
    Mol Biosyst; 2016 Aug 16; 12(9):2713-21. PubMed ID: 27354305
    [Abstract] [Full Text] [Related]

  • 5. Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+CD44+ prostate cancer stem cells.
    Rentala S, Chintala R, Guda M, Chintala M, Komarraju AL, Mangamoori LN.
    Biochem Biophys Res Commun; 2013 Nov 22; 441(3):586-92. PubMed ID: 24177008
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds.
    Ikram N, Mirza MU, Vanmeert M, Froeyen M, Salo-Ahen OMH, Tahir M, Qazi A, Ahmad S.
    Biomolecules; 2019 Mar 28; 9(4):. PubMed ID: 30925835
    [Abstract] [Full Text] [Related]

  • 7. Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as selective ROCK2 inhibitors with anti-breast cancer migration and invasion activities.
    Cao Z, Wei X, Xing S, Zhang J, Wang S, Yue L, Zhang J, Jiang N, Zhai X.
    Bioorg Chem; 2024 Oct 28; 151():107675. PubMed ID: 39126868
    [Abstract] [Full Text] [Related]

  • 8. Development and evaluation of an integrated virtual screening strategy by combining molecular docking and pharmacophore searching based on multiple protein structures.
    Tian S, Sun H, Li Y, Pan P, Li D, Hou T.
    J Chem Inf Model; 2013 Oct 28; 53(10):2743-56. PubMed ID: 24010823
    [Abstract] [Full Text] [Related]

  • 9. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
    Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM.
    Cancer Res; 2012 Oct 01; 72(19):5025-34. PubMed ID: 22846914
    [Abstract] [Full Text] [Related]

  • 10. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
    Green J, Cao J, Bandarage UK, Gao H, Court J, Marhefka C, Jacobs M, Taslimi P, Newsome D, Nakayama T, Shah S, Rodems S.
    J Med Chem; 2015 Jun 25; 58(12):5028-37. PubMed ID: 26039570
    [Abstract] [Full Text] [Related]

  • 11. Discovery of Akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents.
    Chuang CH, Cheng TC, Leu YL, Chuang KH, Tzou SC, Chen CS.
    Int J Mol Sci; 2015 Feb 02; 16(2):3202-12. PubMed ID: 25648320
    [Abstract] [Full Text] [Related]

  • 12. In silico screening-based discovery of benzamide derivatives as inhibitors of Rho-associated kinase-1 (ROCK1).
    Xu QX, Guo L, Li Y, Wang ZW, Hu P, Yang GM, Pan Y.
    J Biomol Struct Dyn; 2024 Sep 02; 42(14):7467-7484. PubMed ID: 37668086
    [Abstract] [Full Text] [Related]

  • 13. Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation.
    Mishra RK, Alokam R, Singhal SM, Srivathsav G, Sriram D, Kaushik-Basu N, Manvar D, Yogeeswari P.
    J Chem Inf Model; 2014 Oct 27; 54(10):2876-86. PubMed ID: 25254429
    [Abstract] [Full Text] [Related]

  • 14. An Integrated In Silico Method to Discover Novel Rock1 Inhibitors: Multi- Complex-Based Pharmacophore, Molecular Dynamics Simulation and Hybrid Protocol Virtual Screening.
    Chen H, Li S, Hu Y, Chen G, Jiang Q, Tong R, Zang Z, Cai L.
    Comb Chem High Throughput Screen; 2016 Oct 27; 19(1):36-50. PubMed ID: 26632439
    [Abstract] [Full Text] [Related]

  • 15. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin.
    Boerma M, Fu Q, Wang J, Loose DS, Bartolozzi A, Ellis JL, McGonigle S, Paradise E, Sweetnam P, Fink LM, Vozenin-Brotons MC, Hauer-Jensen M.
    Blood Coagul Fibrinolysis; 2008 Oct 27; 19(7):709-18. PubMed ID: 18832915
    [Abstract] [Full Text] [Related]

  • 16. High-throughput screening against ~6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery.
    Gong H, Yuan Z, Zhan L.
    Mol Divers; 2016 May 27; 20(2):537-49. PubMed ID: 26700101
    [Abstract] [Full Text] [Related]

  • 17. Determination of potential selective inhibitors for ROCKI and ROCKII isoforms with molecular modeling techniques: structure based docking, ADMET and molecular dynamics simulation.
    Bayel Secinti B, Tatar G, Taskin Tok T.
    J Biomol Struct Dyn; 2019 Jun 27; 37(9):2457-2463. PubMed ID: 30047850
    [Abstract] [Full Text] [Related]

  • 18. Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.
    Patel RA, Liu Y, Wang B, Li R, Sebti SM.
    Oncogene; 2014 Jan 30; 33(5):550-5. PubMed ID: 23396364
    [Abstract] [Full Text] [Related]

  • 19. Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor.
    Jin CH, Jun KY, Lee E, Kim S, Kwon Y, Kim K, Na Y.
    Bioorg Med Chem; 2014 Sep 01; 22(17):4553-65. PubMed ID: 25131958
    [Abstract] [Full Text] [Related]

  • 20. Targeting natural compounds against HER2 kinase domain as potential anticancer drugs applying pharmacophore based molecular modelling approaches.
    Rampogu S, Son M, Baek A, Park C, Rana RM, Zeb A, Parameswaran S, Lee KW.
    Comput Biol Chem; 2018 Jun 01; 74():327-338. PubMed ID: 29702367
    [Abstract] [Full Text] [Related]

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