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Journal Abstract Search

273 related items for PubMed ID: 23552177

  • 1. Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.
    Geier M, Braun A, Fladischer P, Stepniak P, Rudroff F, Hametner C, Mihovilovic MD, Glieder A.
    FEBS J; 2013 Jul; 280(13):3094-108. PubMed ID: 23552177
    [Abstract] [Full Text] [Related]

  • 2. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
    Smith G, Modi S, Pillai I, Lian LY, Sutcliffe MJ, Pritchard MP, Friedberg T, Roberts GC, Wolf CR.
    Biochem J; 1998 May 01; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
    [Abstract] [Full Text] [Related]

  • 3. Change in enantioselectivity in bufuralol 1''-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6.
    Masuda K, Tamagake K, Okuda Y, Torigoe F, Tsuzuki D, Isobe T, Hichiya H, Hanioka N, Yamamoto S, Narimatsu S.
    Chirality; 2005 Jan 01; 17(1):37-43. PubMed ID: 15526337
    [Abstract] [Full Text] [Related]

  • 4. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.
    Lussenburg BM, Keizers PH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN.
    Biochem Pharmacol; 2005 Oct 15; 70(8):1253-61. PubMed ID: 16135359
    [Abstract] [Full Text] [Related]

  • 5. Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.
    Allorge D, Bréant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW.
    Proteins; 2005 May 01; 59(2):339-46. PubMed ID: 15726636
    [Abstract] [Full Text] [Related]

  • 6. Comparison of catalytical activity and stereoselectivity between the recombinant human cytochrome P450 2D6.1 and 2D6.10.
    Kong LM, Qian MR, Hu HH, Xu SY, Yu LS, Jiang HD, Chen SQ, Zeng S.
    Pharmazie; 2012 May 01; 67(5):440-7. PubMed ID: 22764579
    [Abstract] [Full Text] [Related]

  • 7. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H, Guo Z, Persmark M, Mimura M, Inoue K, Guengerich FP, Shimada T.
    Mol Pharmacol; 1994 Sep 01; 46(3):568-77. PubMed ID: 7935340
    [Abstract] [Full Text] [Related]

  • 8. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6.
    Jones BC, Hyland R, Ackland M, Tyman CA, Smith DA.
    Drug Metab Dispos; 1998 Sep 01; 26(9):875-82. PubMed ID: 9733666
    [Abstract] [Full Text] [Related]

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  • 10. Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
    Narimatsu S, Kato R, Horie T, Ono S, Tsutsui M, Yabusaki Y, Ohmori S, Kitada M, Ichioka T, Shimada N, Kato R, Ishikawa T.
    Chirality; 1999 Sep 01; 11(1):1-9. PubMed ID: 9914647
    [Abstract] [Full Text] [Related]

  • 11. Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
    Guengerich FP, Hanna IH, Martin MV, Gillam EM.
    Biochemistry; 2003 Feb 11; 42(5):1245-53. PubMed ID: 12564927
    [Abstract] [Full Text] [Related]

  • 12. Recombinant production of human microsomal cytochrome P450 2D6 in the methylotrophic yeast Pichia pastoris.
    Dietrich M, Grundmann L, Kurr K, Valinotto L, Saussele T, Schmid RD, Lange S.
    Chembiochem; 2005 Nov 11; 6(11):2014-22. PubMed ID: 16222729
    [Abstract] [Full Text] [Related]

  • 13. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR.
    Biochem J; 2004 Jun 01; 380(Pt 2):353-60. PubMed ID: 14992686
    [Abstract] [Full Text] [Related]

  • 14. Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
    Deeni YY, Paine MJ, Ayrton AD, Clarke SE, Chenery R, Wolf CR.
    Arch Biochem Biophys; 2001 Dec 01; 396(1):16-24. PubMed ID: 11716457
    [Abstract] [Full Text] [Related]

  • 15. Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.
    Masuda K, Tamagake K, Katsu T, Torigoe F, Saito K, Hanioka N, Yamano S, Yamamoto S, Narimatsu S.
    Chirality; 2006 Feb 01; 18(3):167-76. PubMed ID: 16432914
    [Abstract] [Full Text] [Related]

  • 16. Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation.
    Lisurek M, Simgen B, Antes I, Bernhardt R.
    Chembiochem; 2008 Jun 16; 9(9):1439-49. PubMed ID: 18481342
    [Abstract] [Full Text] [Related]

  • 17. Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.
    Rea V, Kolkman AJ, Vottero E, Stronks EJ, Ampt KA, Honing M, Vermeulen NP, Wijmenga SS, Commandeur JN.
    Biochemistry; 2012 Jan 24; 51(3):750-60. PubMed ID: 22208729
    [Abstract] [Full Text] [Related]

  • 18. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
    Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA.
    Biochemistry; 2002 Sep 10; 41(36):11025-34. PubMed ID: 12206675
    [Abstract] [Full Text] [Related]

  • 19. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
    Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN.
    Biochem Pharmacol; 2004 Dec 01; 68(11):2263-71. PubMed ID: 15498516
    [Abstract] [Full Text] [Related]

  • 20. Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity.
    Schwarz D, Kisselev P, Schunck WH, Chernogolov A, Boidol W, Cascorbi I, Roots I.
    Pharmacogenetics; 2000 Aug 01; 10(6):519-30. PubMed ID: 10975606
    [Abstract] [Full Text] [Related]

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