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Journal Abstract Search

134 related items for PubMed ID: 23564767

  • 1. PTEN regulates sensitivity of melanoma cells to RO4929097, the γ-secretase inhibitor.
    Nair JS, Sheikh T, Ho AL, Schwartz GK.
    Anticancer Res; 2013 Apr; 33(4):1307-16. PubMed ID: 23564767
    [Abstract] [Full Text] [Related]

  • 2. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
    Hales EC, Taub JW, Matherly LH.
    Cell Signal; 2014 Jan; 26(1):149-61. PubMed ID: 24140475
    [Abstract] [Full Text] [Related]

  • 3. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.
    Huynh C, Poliseno L, Segura MF, Medicherla R, Haimovic A, Menendez S, Shang S, Pavlick A, Shao Y, Darvishian F, Boylan JF, Osman I, Hernando E.
    PLoS One; 2011 Jan; 6(9):e25264. PubMed ID: 21980408
    [Abstract] [Full Text] [Related]

  • 4. Cervical Cancer Cell Growth, Drug Resistance, and Epithelial-Mesenchymal Transition Are Suppressed by y-Secretase Inhibitor RO4929097.
    Wang L, Dai G, Yang J, Wu W, Zhang W.
    Med Sci Monit; 2018 Jun 14; 24():4046-4053. PubMed ID: 29899322
    [Abstract] [Full Text] [Related]

  • 5. Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.
    Lee SM, Moon J, Redman BG, Chidiac T, Flaherty LE, Zha Y, Othus M, Ribas A, Sondak VK, Gajewski TF, Margolin KA.
    Cancer; 2015 Feb 01; 121(3):432-440. PubMed ID: 25250858
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.
    Dantas-Barbosa C, Bergthold G, Daudigeos-Dubus E, Blockus H, Boylan JF, Ferreira C, Puget S, Abely M, Vassal G, Grill J, Geoerger B.
    Anticancer Drugs; 2015 Mar 01; 26(3):272-83. PubMed ID: 25486598
    [Abstract] [Full Text] [Related]

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  • 8. Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells.
    Hales EC, Orr SM, Larson Gedman A, Taub JW, Matherly LH.
    J Biol Chem; 2013 Aug 02; 288(31):22836-48. PubMed ID: 23788636
    [Abstract] [Full Text] [Related]

  • 9. Gamma secretase inhibitor enhances sensitivity to doxorubicin in MDA-MB-231 cells.
    Li ZL, Chen C, Yang Y, Wang C, Yang T, Yang X, Liu SC.
    Int J Clin Exp Pathol; 2015 Aug 02; 8(5):4378-87. PubMed ID: 26191129
    [Abstract] [Full Text] [Related]

  • 10. Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.
    Porcelli L, Mazzotta A, Garofoli M, Di Fonte R, Guida G, Guida M, Tommasi S, Azzariti A.
    Biomed Pharmacother; 2021 Jan 02; 133():111006. PubMed ID: 33202284
    [Abstract] [Full Text] [Related]

  • 11. Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.
    Vo K, Amarasinghe B, Washington K, Gonzalez A, Berlin J, Dang TP.
    Mol Cancer; 2011 Nov 10; 10():138. PubMed ID: 22074495
    [Abstract] [Full Text] [Related]

  • 12. Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.
    Ristorcelli E, Beraud E, Mathieu S, Lombardo D, Verine A.
    Int J Cancer; 2009 Sep 01; 125(5):1016-26. PubMed ID: 19405120
    [Abstract] [Full Text] [Related]

  • 13. Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells.
    Zhu G, Yi X, Haferkamp S, Hesbacher S, Li C, Goebeler M, Gao T, Houben R, Schrama D.
    Cancer Lett; 2016 Jun 28; 376(1):43-52. PubMed ID: 27000992
    [Abstract] [Full Text] [Related]

  • 14. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.
    Luistro L, He W, Smith M, Packman K, Vilenchik M, Carvajal D, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, Linn M, Flohr A, Jakob-Røtne R, Jacobsen H, Glenn K, Heimbrook D, Boylan JF.
    Cancer Res; 2009 Oct 01; 69(19):7672-80. PubMed ID: 19773430
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  • 16. Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.
    Fofaria NM, Frederick DT, Sullivan RJ, Flaherty KT, Srivastava SK.
    Oncotarget; 2015 Dec 01; 6(38):40535-56. PubMed ID: 26497853
    [Abstract] [Full Text] [Related]

  • 17. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.
    Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA.
    Breast Cancer Res Treat; 2012 Jul 01; 134(2):495-510. PubMed ID: 22547109
    [Abstract] [Full Text] [Related]

  • 18. Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer.
    Lee HW, Kim SJ, Choi IJ, Song J, Chun KH.
    Clin Exp Metastasis; 2015 Aug 01; 32(6):593-603. PubMed ID: 26134677
    [Abstract] [Full Text] [Related]

  • 19. Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.
    Kolb EA, Gorlick R, Keir ST, Maris JM, Lock R, Carol H, Kurmasheva RT, Reynolds CP, Kang MH, Wu J, Houghton PJ, Smith MA.
    Pediatr Blood Cancer; 2012 May 01; 58(5):815-8. PubMed ID: 22052798
    [Abstract] [Full Text] [Related]

  • 20. Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer.
    Su F, Zhu S, Ruan J, Muftuoglu Y, Zhang L, Yuan Q.
    Oncotarget; 2016 Jan 26; 7(4):4142-54. PubMed ID: 26716652
    [Abstract] [Full Text] [Related]

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