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184 related items for PubMed ID: 23569176

  • 1. Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
    Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP.
    Drug Metab Dispos; 2013 Jun; 41(6):1174-8. PubMed ID: 23569176
    [Abstract] [Full Text] [Related]

  • 2. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
    Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW.
    Drug Metab Dispos; 2012 Sep; 40(9):1825-33. PubMed ID: 22711747
    [Abstract] [Full Text] [Related]

  • 3. Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.
    Fuchs H, Kishimoto W, Gansser D, Tanswell P, Ishiguro N.
    Drug Metab Dispos; 2014 Oct; 42(10):1761-5. PubMed ID: 25053619
    [Abstract] [Full Text] [Related]

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  • 5. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
    Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.
    Antimicrob Agents Chemother; 2007 Sep; 51(9):3230-4. PubMed ID: 17576841
    [Abstract] [Full Text] [Related]

  • 6. Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.
    Sampson KE, Brinker A, Pratt J, Venkatraman N, Xiao Y, Blasberg J, Steiner T, Bourner M, Thompson DC.
    Drug Metab Dispos; 2015 Feb; 43(2):199-207. PubMed ID: 25388687
    [Abstract] [Full Text] [Related]

  • 7. Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models.
    Nakanishi H, Yonezawa A, Matsubara K, Yano I.
    Eur J Pharmacol; 2013 Jun 15; 710(1-3):20-8. PubMed ID: 23588114
    [Abstract] [Full Text] [Related]

  • 8. Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology.
    Andersen V, Svenningsen K, Knudsen LA, Hansen AK, Holmskov U, Stensballe A, Vogel U.
    World J Gastroenterol; 2015 Nov 07; 21(41):11862-76. PubMed ID: 26557010
    [Abstract] [Full Text] [Related]

  • 9. Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice.
    Geyer J, Gavrilova O, Petzinger E.
    J Vet Pharmacol Ther; 2009 Feb 07; 32(1):87-96. PubMed ID: 19161460
    [Abstract] [Full Text] [Related]

  • 10. Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.
    Huang L, Li X, Roberts J, Janosky B, Lin MH.
    Xenobiotica; 2015 Feb 07; 45(6):547-55. PubMed ID: 25539457
    [Abstract] [Full Text] [Related]

  • 11. The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
    Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B.
    Drug Metab Dispos; 2009 May 07; 37(5):946-55. PubMed ID: 19225039
    [Abstract] [Full Text] [Related]

  • 12. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
    Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.
    J Pharmacol Exp Ther; 2010 Jun 07; 333(3):788-96. PubMed ID: 20304939
    [Abstract] [Full Text] [Related]

  • 13. Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats.
    Hoffmann K, Löscher W.
    Epilepsia; 2007 Apr 07; 48(4):631-45. PubMed ID: 17437408
    [Abstract] [Full Text] [Related]

  • 14. Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats.
    Miyake T.
    Biol Pharm Bull; 2020 Mar 01; 43(3):384-392. PubMed ID: 31685755
    [Abstract] [Full Text] [Related]

  • 15. Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
    Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, Sugiyama Y.
    J Pharmacol Exp Ther; 2011 Dec 01; 339(3):935-44. PubMed ID: 21934030
    [Abstract] [Full Text] [Related]

  • 16. Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation.
    Yousif S, Chaves C, Potin S, Margaill I, Scherrmann JM, Declèves X.
    J Neurochem; 2012 Nov 01; 123(4):491-503. PubMed ID: 22845665
    [Abstract] [Full Text] [Related]

  • 17. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
    Yamada A, Maeda K, Kamiyama E, Sugiyama D, Kondo T, Shiroyanagi Y, Nakazawa H, Okano T, Adachi M, Schuetz JD, Adachi Y, Hu Z, Kusuhara H, Sugiyama Y.
    Drug Metab Dispos; 2007 Dec 01; 35(12):2166-76. PubMed ID: 17823233
    [Abstract] [Full Text] [Related]

  • 18. ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate.
    Hashimoto N, Nakamichi N, Uwafuji S, Yoshida K, Sugiura T, Tsuji A, Kato Y.
    J Control Release; 2013 Jan 10; 165(1):54-61. PubMed ID: 23089896
    [Abstract] [Full Text] [Related]

  • 19. Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes.
    Turncliff RZ, Tian X, Brouwer KL.
    Biochem Pharmacol; 2006 May 14; 71(10):1520-9. PubMed ID: 16542640
    [Abstract] [Full Text] [Related]

  • 20. Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
    Zhang S, Wang X, Sagawa K, Morris ME.
    Drug Metab Dispos; 2005 Mar 14; 33(3):341-8. PubMed ID: 15608138
    [Abstract] [Full Text] [Related]

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