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Journal Abstract Search

129 related items for PubMed ID: 23583910

  • 1. Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.
    Lange S, Keller M, Müller C, Oliaro-Bosso S, Balliano G, Bracher F.
    Eur J Med Chem; 2013 May; 63():758-64. PubMed ID: 23583910
    [Abstract] [Full Text] [Related]

  • 2. Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae.
    Oliaro-Bosso S, Ceruti M, Balliano G, Milla P, Rocco F, Viola F.
    Lipids; 2005 Dec; 40(12):1257-62. PubMed ID: 16477810
    [Abstract] [Full Text] [Related]

  • 3. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
    Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A.
    Nature; 2004 Nov 04; 432(7013):118-22. PubMed ID: 15525992
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.
    Galli U, Oliaro-Bosso S, Taramino S, Venegoni S, Pastore E, Tron GC, Balliano G, Viola F, Sorba G.
    Bioorg Med Chem Lett; 2007 Jan 01; 17(1):220-4. PubMed ID: 17027267
    [Abstract] [Full Text] [Related]

  • 5. Inhibitory effect of umbelliferone aminoalkyl derivatives on oxidosqualene cyclases from S. cerevisiae, T. cruzi, P. carinii, H. sapiens, and A. thaliana: a structure-activity study.
    Oliaro-Bosso S, Viola F, Taramino S, Tagliapietra S, Barge A, Cravotto G, Balliano G.
    ChemMedChem; 2007 Feb 01; 2(2):226-33. PubMed ID: 17154325
    [Abstract] [Full Text] [Related]

  • 6. NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes.
    Tani O, Akutsu Y, Ito S, Suzuki T, Tateishi Y, Yamaguchi T, Niimi T, Namatame I, Chiba Y, Sakashita H, Kubota T, Yanagi T, Mizukami S, Hirayama K, Furukawa K, Yamasaki K.
    J Med Chem; 2018 Jun 14; 61(11):5047-5053. PubMed ID: 29771525
    [Abstract] [Full Text] [Related]

  • 7. Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.
    Buckner FS, Griffin JH, Wilson AJ, Van Voorhis WC.
    Antimicrob Agents Chemother; 2001 Apr 14; 45(4):1210-5. PubMed ID: 11257036
    [Abstract] [Full Text] [Related]

  • 8. Biosynthetic Mechanism of Lanosterol: Cyclization.
    Chen N, Wang S, Smentek L, Hess BA, Wu R.
    Angew Chem Int Ed Engl; 2015 Jul 20; 54(30):8693-6. PubMed ID: 26069216
    [Abstract] [Full Text] [Related]

  • 9. Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.
    Balliano G, Dehmlow H, Oliaro-Bosso S, Scaldaferri M, Taramino S, Viola F, Caron G, Aebi J, Ackermann J.
    Bioorg Med Chem Lett; 2009 Feb 01; 19(3):718-23. PubMed ID: 19119009
    [Abstract] [Full Text] [Related]

  • 10. Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
    Keller M, Wolfgardt A, Müller C, Wilcken R, Böckler FM, Oliaro-Bosso S, Ferrante T, Balliano G, Bracher F.
    Eur J Med Chem; 2016 Feb 15; 109():13-22. PubMed ID: 26745812
    [Abstract] [Full Text] [Related]

  • 11. Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases.
    Rocco F, Bosso SO, Viola F, Milla P, Roma G, Grossi G, Ceruti M.
    Lipids; 2003 Mar 15; 38(3):201-7. PubMed ID: 12784859
    [Abstract] [Full Text] [Related]

  • 12. Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles.
    Brown GR, Hollinshead DM, Stokes ES, Clarke DS, Eakin MA, Foubister AJ, Glossop SC, Griffiths D, Johnson MC, McTaggart F, Mirrlees DJ, Smith GJ, Wood R.
    J Med Chem; 1999 Apr 08; 42(7):1306-11. PubMed ID: 10197973
    [Abstract] [Full Text] [Related]

  • 13. Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.
    Watanabe T, Umezawa Y, Takahashi Y, Akamatsu Y.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5807-10. PubMed ID: 20728352
    [Abstract] [Full Text] [Related]

  • 14. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
    Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J.
    J Lipid Res; 1997 Feb 01; 38(2):373-90. PubMed ID: 9162756
    [Abstract] [Full Text] [Related]

  • 15. Mechanistic insights into oxidosqualene cyclizations through homology modeling.
    Schulz-Gasch T, Stahl M.
    J Comput Chem; 2003 Apr 30; 24(6):741-53. PubMed ID: 12666166
    [Abstract] [Full Text] [Related]

  • 16. Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives.
    Barth MM, Binet JL, Thomas DM, de Fornel DC, Samreth S, Schuber FJ, Renaut PP.
    J Med Chem; 1996 Jun 07; 39(12):2302-12. PubMed ID: 8691425
    [Abstract] [Full Text] [Related]

  • 17. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.
    Huff MW, Telford DE.
    Trends Pharmacol Sci; 2005 Jul 07; 26(7):335-40. PubMed ID: 15951028
    [Abstract] [Full Text] [Related]

  • 18. Oxidosqualene cyclase inhibitors as antimicrobial agents.
    Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD.
    J Med Chem; 2003 Sep 25; 46(20):4240-3. PubMed ID: 13678402
    [Abstract] [Full Text] [Related]

  • 19. Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases.
    Ceruti M, Balliano G, Rocco F, Milla P, Arpicco S, Cattel L, Viola F.
    Lipids; 2001 Jun 25; 36(6):629-36. PubMed ID: 11485168
    [Abstract] [Full Text] [Related]

  • 20. Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a).
    Brown GR, Foubister AJ, Johnson MC, Newcombe NJ, Waterson D, Wells SL.
    Bioorg Med Chem Lett; 2001 Aug 20; 11(16):2213-6. PubMed ID: 11514173
    [Abstract] [Full Text] [Related]

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