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248 related items for PubMed ID: 23592791

  • 1. Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.
    Maurya IK, Thota CK, Verma SD, Sharma J, Rawal MK, Ravikumar B, Sen S, Chauhan N, Lynn AM, Chauhan VS, Prasad R.
    J Biol Chem; 2013 Jun 07; 288(23):16775-16787. PubMed ID: 23592791
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  • 2. ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.
    Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD.
    Antimicrob Agents Chemother; 2008 Nov 07; 52(11):3851-62. PubMed ID: 18710914
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  • 3. FK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates of Candida albicans.
    Nim S, Rawal MK, Prasad R.
    FEMS Yeast Res; 2014 Jun 07; 14(4):624-32. PubMed ID: 24628911
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  • 4. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.
    Sanglard D, Ischer F, Monod M, Bille J.
    Microbiology (Reading); 1997 Feb 07; 143 ( Pt 2)():405-416. PubMed ID: 9043118
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  • 5. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
    Holmes AR, Keniya MV, Ivnitski-Steele I, Monk BC, Lamping E, Sklar LA, Cannon RD.
    Antimicrob Agents Chemother; 2012 Mar 07; 56(3):1508-15. PubMed ID: 22203607
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  • 6. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.
    Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.
    Antimicrob Agents Chemother; 1995 Nov 07; 39(11):2378-86. PubMed ID: 8585712
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  • 7. Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance.
    Niimi M, Niimi K, Takano Y, Holmes AR, Fischer FJ, Uehara Y, Cannon RD.
    J Antimicrob Chemother; 2004 Dec 07; 54(6):999-1006. PubMed ID: 15486081
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  • 10. Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.
    Tsao S, Weber S, Cameron C, Nehme D, Ahmadzadeh E, Raymond M.
    J Antimicrob Chemother; 2016 Nov 07; 71(11):3125-3134. PubMed ID: 27402010
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  • 12. Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.
    Nim S, Lobato LG, Moreno A, Chaptal V, Rawal MK, Falson P, Prasad R.
    Biochim Biophys Acta; 2016 Nov 07; 1858(11):2858-2870. PubMed ID: 27569110
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  • 14. Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition.
    Niimi M, Niimi K, Tanabe K, Cannon RD, Lamping E.
    Antimicrob Agents Chemother; 2022 Jan 18; 66(1):e0174821. PubMed ID: 34780272
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  • 15. Deletion of transmembrane domain 12 of CDR1, a multidrug transporter from Candida albicans, leads to altered drug specificity: expression of a yeast multidrug transporter in baculovirus expression system.
    Krishnamurthy S, Chatterjee U, Gupta V, Prasad R, Das P, Snehlata P, Hasnain SE, Prasad R.
    Yeast; 1998 Apr 30; 14(6):535-50. PubMed ID: 9605504
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  • 17. Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1.
    Madani G, Lamping E, Cannon RD.
    mSphere; 2021 Feb 10; 6(1):. PubMed ID: 33568458
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  • 18. Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element.
    Gaur NA, Manoharlal R, Saini P, Prasad T, Mukhopadhyay G, Hoefer M, Morschhäuser J, Prasad R.
    Biochem Biophys Res Commun; 2005 Jun 24; 332(1):206-14. PubMed ID: 15896319
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  • 19. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model.
    Mónico A, Nim S, Duarte N, Rawal MK, Prasad R, Di Pietro A, Ferreira MU.
    Bioorg Med Chem; 2017 Jul 01; 25(13):3278-3284. PubMed ID: 28479022
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