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Journal Abstract Search

129 related items for PubMed ID: 2363122

  • 1. Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin.
    Krstenansky JL, Broersma RJ, Owen TJ, Payne MH, Yates MT, Mao SJ.
    Thromb Haemost; 1990 Apr 12; 63(2):208-14. PubMed ID: 2363122
    [Abstract] [Full Text] [Related]

  • 2. Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II.
    Monteiro RQ, Rapôso JG, Wisner A, Guimarães JA, Bon C, Zingali RB.
    Biochem Biophys Res Commun; 1999 Sep 07; 262(3):819-22. PubMed ID: 10471408
    [Abstract] [Full Text] [Related]

  • 3. Probing the distance between the two binding sites of hirudin for its interaction with the active site and the fibrin(ogen)-binding site of alpha-thrombin.
    Wagner U, Schmitz T, Otte M, Dodt J.
    Biomed Biochim Acta; 1991 Sep 07; 50(4-6):707-10. PubMed ID: 1801747
    [Abstract] [Full Text] [Related]

  • 4. Hirudins: from leeches to man.
    Wallis RB.
    Semin Thromb Hemost; 1996 Sep 07; 22(2):185-96. PubMed ID: 8807716
    [Abstract] [Full Text] [Related]

  • 5. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
    Lombardi A, Nastri F, Della Morte R, Rossi A, De Rosa A, Staiano N, Pedone C, Pavone V.
    J Med Chem; 1996 May 10; 39(10):2008-17. PubMed ID: 8642559
    [Abstract] [Full Text] [Related]

  • 6. Hirudin as alternative anticoagulant--a historical review.
    Markwardt F.
    Semin Thromb Hemost; 2002 Oct 10; 28(5):405-14. PubMed ID: 12420235
    [Abstract] [Full Text] [Related]

  • 7. The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides.
    Krstenansky JL, Owen TJ, Yates MT, Mao SJ.
    FEBS Lett; 1990 Sep 03; 269(2):425-9. PubMed ID: 2401369
    [Abstract] [Full Text] [Related]

  • 8. Comparison of hirudin and hirudin PA C-terminal fragments and related analogs as antithrombin agents.
    Krstenansky JL, Owen TJ, Yates MT, Mao SJ.
    Thromb Res; 1988 Oct 15; 52(2):137-41. PubMed ID: 3194888
    [Abstract] [Full Text] [Related]

  • 9. [Recent developments in the biochemistry of hirudins].
    Walsmann P.
    Folia Haematol Int Mag Klin Morphol Blutforsch; 1989 Oct 15; 116(6):821-30. PubMed ID: 2483699
    [Abstract] [Full Text] [Related]

  • 10. A screening procedure to evaluate the anticoagulant activity and the kinetic behaviour of direct thrombin inhibitors.
    Rupin A, Mennecier P, de Nanteuil G, Laubie M, Verbeuren TJ.
    Thromb Res; 1995 May 01; 78(3):217-25. PubMed ID: 7631302
    [Abstract] [Full Text] [Related]

  • 11. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I.
    Myles T, Le Bonniec BF, Betz A, Stone SR.
    Biochemistry; 2001 Apr 24; 40(16):4972-9. PubMed ID: 11305913
    [Abstract] [Full Text] [Related]

  • 12. Covalent linkage of streptokinase to recombinant hirudin: a novel thrombolytic agent with antithrombotic properties.
    Phaneuf MD, Ozaki CK, Johnstone MT, Loza JP, Quist WC, LoGerfo FW.
    Thromb Haemost; 1994 Apr 24; 71(4):481-7. PubMed ID: 8052967
    [Abstract] [Full Text] [Related]

  • 13. Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats.
    Hérault JP, Bernat A, Gaich C, Herbert M.
    Thromb Haemost; 2002 Feb 24; 87(2):238-44. PubMed ID: 11858483
    [Abstract] [Full Text] [Related]

  • 14. Domains specifying thrombin-receptor interaction.
    Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR.
    Nature; 1991 Oct 17; 353(6345):674-7. PubMed ID: 1717851
    [Abstract] [Full Text] [Related]

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  • 18. Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity.
    Mao SJ, Yates MT, Owen TJ, Krstenansky JL.
    Biochemistry; 1988 Oct 18; 27(21):8170-3. PubMed ID: 3233202
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  • 20. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

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