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Journal Abstract Search

141 related items for PubMed ID: 23654226

  • 1. Nonempirical energetic analysis of reactivity and covalent inhibition of fatty acid amide hydrolase.
    Chudyk EI, Dyguda-Kazimierowicz E, Langner KM, Sokalski WA, Lodola A, Mor M, Sirirak J, Mulholland AJ.
    J Phys Chem B; 2013 Jun 06; 117(22):6656-66. PubMed ID: 23654226
    [Abstract] [Full Text] [Related]

  • 2. Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling.
    Lodola A, Mor M, Sirirak J, Mulholland AJ.
    Biochem Soc Trans; 2009 Apr 06; 37(Pt 2):363-7. PubMed ID: 19290863
    [Abstract] [Full Text] [Related]

  • 3. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling.
    Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ.
    Chem Commun (Camb); 2011 Mar 07; 47(9):2517-9. PubMed ID: 21240393
    [Abstract] [Full Text] [Related]

  • 4. Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties.
    Patricelli MP, Lovato MA, Cravatt BF.
    Biochemistry; 1999 Aug 03; 38(31):9804-12. PubMed ID: 10433686
    [Abstract] [Full Text] [Related]

  • 5. QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.
    Lodola A, Mor M, Hermann JC, Tarzia G, Piomelli D, Mulholland AJ.
    Chem Commun (Camb); 2005 Sep 21; (35):4399-401. PubMed ID: 16136230
    [Abstract] [Full Text] [Related]

  • 6. Application of computational methods to the design of fatty acid amide hydrolase (FAAH) inhibitors based on a carbamic template structure.
    Lodola A, Rivara S, Mor M.
    Adv Protein Chem Struct Biol; 2011 Sep 21; 85():1-26. PubMed ID: 21920320
    [Abstract] [Full Text] [Related]

  • 7. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
    Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M.
    J Med Chem; 2013 Mar 28; 56(6):2500-12. PubMed ID: 23425199
    [Abstract] [Full Text] [Related]

  • 8. Probing the Ser-Ser-Lys catalytic triad mechanism of peptide amidase: computational studies of the ground state, transition state, and intermediate.
    Valiña AL, Mazumder-Shivakumar D, Bruice TC.
    Biochemistry; 2004 Dec 21; 43(50):15657-72. PubMed ID: 15595822
    [Abstract] [Full Text] [Related]

  • 9. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase.
    McKinney MK, Cravatt BF.
    J Biol Chem; 2003 Sep 26; 278(39):37393-9. PubMed ID: 12734197
    [Abstract] [Full Text] [Related]

  • 10. Computational insights into function and inhibition of fatty acid amide hydrolase.
    Palermo G, Rothlisberger U, Cavalli A, De Vivo M.
    Eur J Med Chem; 2015 Feb 16; 91():15-26. PubMed ID: 25240419
    [Abstract] [Full Text] [Related]

  • 11. Differential transition-state stabilization in enzyme catalysis: quantum chemical analysis of interactions in the chorismate mutase reaction and prediction of the optimal catalytic field.
    Szefczyk B, Mulholland AJ, Ranaghan KE, Sokalski WA.
    J Am Chem Soc; 2004 Dec 15; 126(49):16148-59. PubMed ID: 15584751
    [Abstract] [Full Text] [Related]

  • 12. Physical nature of intermolecular interactions within cAMP-dependent protein kinase active site: differential transition state stabilization in phosphoryl transfer reaction.
    Szarek P, Dyguda-Kazimierowicz E, Tachibana A, Sokalski WA.
    J Phys Chem B; 2008 Sep 18; 112(37):11819-26. PubMed ID: 18720966
    [Abstract] [Full Text] [Related]

  • 13. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
    Patricelli MP, Cravatt BF.
    Biochemistry; 2001 May 22; 40(20):6107-15. PubMed ID: 11352748
    [Abstract] [Full Text] [Related]

  • 14. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
    Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC.
    J Mol Biol; 2010 Jul 23; 400(4):743-54. PubMed ID: 20493882
    [Abstract] [Full Text] [Related]

  • 15. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling.
    Lodola A, Mor M, Rivara S, Christov C, Tarzia G, Piomelli D, Mulholland AJ.
    Chem Commun (Camb); 2008 Jan 14; (2):214-6. PubMed ID: 18092091
    [Abstract] [Full Text] [Related]

  • 16. Anandamide hydrolysis in FAAH reveals a dual strategy for efficient enzyme-assisted amide bond cleavage via nitrogen inversion.
    Palermo G, Campomanes P, Cavalli A, Rothlisberger U, De Vivo M.
    J Phys Chem B; 2015 Jan 22; 119(3):789-801. PubMed ID: 25205244
    [Abstract] [Full Text] [Related]

  • 17. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes.
    Alexander JP, Cravatt BF.
    Chem Biol; 2005 Nov 22; 12(11):1179-87. PubMed ID: 16298297
    [Abstract] [Full Text] [Related]

  • 18. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
    Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D.
    J Med Chem; 2004 Oct 07; 47(21):4998-5008. PubMed ID: 15456244
    [Abstract] [Full Text] [Related]

  • 19. Clarifying the catalytic roles of conserved residues in the amidase signature family.
    Patricelli MP, Cravatt BF.
    J Biol Chem; 2000 Jun 23; 275(25):19177-84. PubMed ID: 10764768
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
    Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D.
    ChemMedChem; 2006 Jan 23; 1(1):130-9. PubMed ID: 16892344
    [Abstract] [Full Text] [Related]

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