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Journal Abstract Search

197 related items for PubMed ID: 23758947

  • 1. Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
    Green LK, Syddall SP, Carlin KM, Bell GD, Guise CP, Mowday AM, Hay MP, Smaill JB, Patterson AV, Ackerley DF.
    Mol Cancer; 2013 Jun 10; 12():58. PubMed ID: 23758947
    [Abstract] [Full Text] [Related]

  • 2. Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy.
    Chan-Hyams JVE, Copp JN, Smaill JB, Patterson AV, Ackerley DF.
    Biochem Pharmacol; 2018 Dec 10; 158():192-200. PubMed ID: 30352235
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  • 3. The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy.
    Green LK, Storey MA, Williams EM, Patterson AV, Smaill JB, Copp JN, Ackerley DF.
    Cancers (Basel); 2013 Aug 08; 5(3):985-97. PubMed ID: 24202330
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  • 4. Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.
    Sharrock AV, McManaway SP, Rich MH, Mumm JS, Hermans IF, Tercel M, Pruijn FB, Ackerley DF.
    Front Pharmacol; 2021 Aug 08; 12():701456. PubMed ID: 34163368
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  • 5. Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.
    Prosser GA, Copp JN, Mowday AM, Guise CP, Syddall SP, Williams EM, Horvat CN, Swe PM, Ashoorzadeh A, Denny WA, Smaill JB, Patterson AV, Ackerley DF.
    Biochem Pharmacol; 2013 Apr 15; 85(8):1091-103. PubMed ID: 23399641
    [Abstract] [Full Text] [Related]

  • 6. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.
    Prosser GA, Copp JN, Syddall SP, Williams EM, Smaill JB, Wilson WR, Patterson AV, Ackerley DF.
    Biochem Pharmacol; 2010 Mar 01; 79(5):678-87. PubMed ID: 19852945
    [Abstract] [Full Text] [Related]

  • 7. Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy.
    Ruiz de Garibay G, García de Jalón E, Stigen E, Lund KB, Popa M, Davidson B, Safont MM, Rygh CB, Espedal H, Barrett TM, Haug BE, McCormack E.
    Theranostics; 2021 Mar 01; 11(12):6044-6057. PubMed ID: 33897898
    [Abstract] [Full Text] [Related]

  • 8. Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators.
    Wilson WR, Stribbling SM, Pruijn FB, Syddall SP, Patterson AV, Liyanage HD, Smith E, Botting KJ, Tercel M.
    Mol Cancer Ther; 2009 Oct 01; 8(10):2903-13. PubMed ID: 19808982
    [Abstract] [Full Text] [Related]

  • 9. Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
    Williams EM, Rich MH, Mowday AM, Ashoorzadeh A, Copp JN, Guise CP, Anderson RF, Flanagan JU, Smaill JB, Patterson AV, Ackerley DF.
    Biochemistry; 2019 Sep 03; 58(35):3700-3710. PubMed ID: 31403283
    [Abstract] [Full Text] [Related]

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  • 13. Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
    Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA.
    J Med Chem; 2007 Mar 22; 50(6):1197-212. PubMed ID: 17326614
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  • 17. Nitroreductase-based GDEPT.
    Denny WA.
    Curr Pharm Des; 2002 Mar 22; 8(15):1349-61. PubMed ID: 12052212
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  • 18. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
    Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF.
    Biochem J; 2015 Oct 15; 471(2):131-53. PubMed ID: 26431849
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  • 19. Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli.
    Whiteway J, Koziarz P, Veall J, Sandhu N, Kumar P, Hoecher B, Lambert IB.
    J Bacteriol; 1998 Nov 15; 180(21):5529-39. PubMed ID: 9791100
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