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Journal Abstract Search

269 related items for PubMed ID: 23824742

  • 1. Novel small-molecule inhibitors of Bcl-XL to treat lung cancer.
    Park D, Magis AT, Li R, Owonikoko TK, Sica GL, Sun SY, Ramalingam SS, Khuri FR, Curran WJ, Deng X.
    Cancer Res; 2013 Sep 01; 73(17):5485-96. PubMed ID: 23824742
    [Abstract] [Full Text] [Related]

  • 2. Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.
    Rooswinkel RW, van de Kooij B, Verheij M, Borst J.
    Cell Death Dis; 2012 Aug 09; 3(8):e366. PubMed ID: 22875003
    [Abstract] [Full Text] [Related]

  • 3. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
    Chen S, Dai Y, Harada H, Dent P, Grant S.
    Cancer Res; 2007 Jan 15; 67(2):782-91. PubMed ID: 17234790
    [Abstract] [Full Text] [Related]

  • 4. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
    Rahmani M, Aust MM, Attkisson E, Williams DC, Ferreira-Gonzalez A, Grant S.
    Cancer Res; 2013 Feb 15; 73(4):1340-51. PubMed ID: 23243017
    [Abstract] [Full Text] [Related]

  • 5. Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.
    Rahmani M, Aust MM, Hawkins E, Parker RE, Ross M, Kmieciak M, Reshko LB, Rizzo KA, Dumur CI, Ferreira-Gonzalez A, Grant S.
    Haematologica; 2015 Dec 15; 100(12):1553-63. PubMed ID: 26452980
    [Abstract] [Full Text] [Related]

  • 6. 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
    Lin X, Morgan-Lappe S, Huang X, Li L, Zakula DM, Vernetti LA, Fesik SW, Shen Y.
    Oncogene; 2007 Jun 07; 26(27):3972-9. PubMed ID: 17173063
    [Abstract] [Full Text] [Related]

  • 7. Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.
    Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Differ; 2018 Mar 07; 25(4):721-734. PubMed ID: 29459767
    [Abstract] [Full Text] [Related]

  • 8. Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.
    Okumura K, Huang S, Sinicrope FA.
    Clin Cancer Res; 2008 Dec 15; 14(24):8132-42. PubMed ID: 19088028
    [Abstract] [Full Text] [Related]

  • 9. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy.
    Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed JC.
    PLoS One; 2011 Dec 15; 6(9):e24102. PubMed ID: 21949692
    [Abstract] [Full Text] [Related]

  • 10. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.
    Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
    Cell Death Differ; 2012 Nov 15; 19(11):1856-69. PubMed ID: 22790873
    [Abstract] [Full Text] [Related]

  • 11. ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL.
    Li JY, Li YY, Jin W, Yang Q, Shao ZM, Tian XS.
    J Exp Clin Cancer Res; 2012 Dec 23; 31(1):102. PubMed ID: 23259599
    [Abstract] [Full Text] [Related]

  • 12. Discovery of Small Molecule Bak Activator for Lung Cancer Therapy.
    Park D, Anisuzzaman ASM, Magis AT, Chen G, Xie M, Zhang G, Behera M, Sica GL, Ramalingam SS, Owonikoko TK, Deng X.
    Theranostics; 2021 Dec 23; 11(17):8500-8516. PubMed ID: 34373755
    [Abstract] [Full Text] [Related]

  • 13. The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib.
    Hikita H, Takehara T, Shimizu S, Kodama T, Shigekawa M, Iwase K, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Hayashi N.
    Hepatology; 2010 Oct 23; 52(4):1310-21. PubMed ID: 20799354
    [Abstract] [Full Text] [Related]

  • 14. BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
    Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.
    Hepatology; 2009 Dec 23; 50(6):1972-80. PubMed ID: 19839062
    [Abstract] [Full Text] [Related]

  • 15. γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells.
    Séveno C, Loussouarn D, Bréchet S, Campone M, Juin P, Barillé-Nion S.
    Breast Cancer Res; 2012 Jun 15; 14(3):R96. PubMed ID: 22703841
    [Abstract] [Full Text] [Related]

  • 16. Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.
    Clerc P, Ge SX, Hwang H, Waddell J, Roelofs BA, Karbowski M, Sesaki H, Polster BM.
    Br J Pharmacol; 2014 Apr 15; 171(8):1988-99. PubMed ID: 24206264
    [Abstract] [Full Text] [Related]

  • 17. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.
    Hari Y, Harashima N, Tajima Y, Harada M.
    Oncotarget; 2015 Dec 08; 6(39):41902-15. PubMed ID: 26506422
    [Abstract] [Full Text] [Related]

  • 18. Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak.
    Sun JG, Xiang J, Zeng XL, Li X, Wu P, Fung KP, Liu FY.
    Cancer Lett; 2014 Dec 28; 355(2):253-63. PubMed ID: 25304383
    [Abstract] [Full Text] [Related]

  • 19. Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy.
    Ritter V, Krautter F, Klein D, Jendrossek V, Rudner J.
    Cell Death Dis; 2021 Jul 13; 12(7):694. PubMed ID: 34257274
    [Abstract] [Full Text] [Related]

  • 20. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.
    Lindqvist LM, Heinlein M, Huang DC, Vaux DL.
    Proc Natl Acad Sci U S A; 2014 Jun 10; 111(23):8512-7. PubMed ID: 24912196
    [Abstract] [Full Text] [Related]

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