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1226 related items for PubMed ID: 23830905

  • 1. Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.
    Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.
    Neuroscience; 2013 Oct 10; 250():8-19. PubMed ID: 23830905
    [Abstract] [Full Text] [Related]

  • 2. Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice.
    Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.
    Neuroscience; 2013 Feb 12; 231():49-60. PubMed ID: 23201826
    [Abstract] [Full Text] [Related]

  • 3. Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.
    Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M.
    Acta Neuropathol Commun; 2014 Jul 15; 2():78. PubMed ID: 25022663
    [Abstract] [Full Text] [Related]

  • 4. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
    Wang S, Ni HM, Chao X, Wang H, Bridges B, Kumer S, Schmitt T, Mareninova O, Gukovskaya A, De Lisle RC, Ballabio A, Pacher P, Ding WX.
    Autophagy; 2019 Nov 15; 15(11):1954-1969. PubMed ID: 30894069
    [Abstract] [Full Text] [Related]

  • 5. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.
    Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A.
    Mol Neurodegener; 2018 Sep 04; 13(1):48. PubMed ID: 30180904
    [Abstract] [Full Text] [Related]

  • 6. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T.
    Mol Neurodegener; 2016 Jun 24; 11(1):46. PubMed ID: 27341800
    [Abstract] [Full Text] [Related]

  • 7. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
    Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC.
    Autophagy; 2019 Jun 24; 15(6):1082-1099. PubMed ID: 30654731
    [Abstract] [Full Text] [Related]

  • 8. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
    Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z, Wang G.
    EMBO J; 2016 Jan 18; 35(2):121-42. PubMed ID: 26702100
    [Abstract] [Full Text] [Related]

  • 9. Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
    Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A.
    Autophagy; 2019 Apr 18; 15(4):631-651. PubMed ID: 30335591
    [Abstract] [Full Text] [Related]

  • 10. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
    Arrant AE, Onyilo VC, Unger DE, Roberson ED.
    J Neurosci; 2018 Feb 28; 38(9):2341-2358. PubMed ID: 29378861
    [Abstract] [Full Text] [Related]

  • 11. Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
    Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F.
    Nat Commun; 2017 May 25; 8():15277. PubMed ID: 28541286
    [Abstract] [Full Text] [Related]

  • 12. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
    Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A.
    EMBO J; 2012 Mar 07; 31(5):1095-108. PubMed ID: 22343943
    [Abstract] [Full Text] [Related]

  • 13. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
    Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.
    Acta Neuropathol; 2014 Mar 07; 127(6):845-60. PubMed ID: 24619111
    [Abstract] [Full Text] [Related]

  • 14. Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner.
    Sakai M, Ohnishi K, Masuda M, Ohminami H, Yamanaka-Okumura H, Hara T, Taketani Y.
    Biosci Biotechnol Biochem; 2020 Jun 07; 84(6):1221-1231. PubMed ID: 32046625
    [Abstract] [Full Text] [Related]

  • 15. Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.
    Li D, Shao R, Wang N, Zhou N, Du K, Shi J, Wang Y, Zhao Z, Ye X, Zhang X, Xu H.
    Autophagy; 2021 Apr 07; 17(4):872-887. PubMed ID: 32138578
    [Abstract] [Full Text] [Related]

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  • 17. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
    Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, Luo J, Lee JK, Liang C, Chen JF.
    Autophagy; 2020 Sep 07; 16(9):1635-1650. PubMed ID: 31847700
    [Abstract] [Full Text] [Related]

  • 18. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.
    Zhu S, Tai C, Petkau TL, Zhang S, Liao C, Dong Z, Wen W, Chang Q, Tian Wang Y, MacVicar BA, Leavitt BR, Jia W, Cynader MS.
    Brain Res; 2013 Sep 12; 1530():54-65. PubMed ID: 23887054
    [Abstract] [Full Text] [Related]

  • 19. Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.
    Zhou X, Sun L, Brady OA, Murphy KA, Hu F.
    Acta Neuropathol Commun; 2017 Jan 26; 5(1):9. PubMed ID: 28126008
    [Abstract] [Full Text] [Related]

  • 20. Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway.
    Tan X, Guan H, Yang Y, Luo S, Hou L, Chen H, Li J.
    Toxicol Appl Pharmacol; 2020 Aug 15; 401():115090. PubMed ID: 32512069
    [Abstract] [Full Text] [Related]

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