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207 related items for PubMed ID: 23841915

  • 1. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.
    Golubovskaya VM, Ho B, Zheng M, Magis A, Ostrov D, Morrison C, Cance WG.
    BMC Cancer; 2013 Jul 11; 13():342. PubMed ID: 23841915
    [Abstract] [Full Text] [Related]

  • 2. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.
    Golubovskaya VM, Palma NL, Zheng M, Ho B, Magis A, Ostrov D, Cance WG.
    Anticancer Agents Med Chem; 2013 May 11; 13(4):532-45. PubMed ID: 22292771
    [Abstract] [Full Text] [Related]

  • 3. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
    Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG.
    Carcinogenesis; 2012 May 11; 33(5):1004-13. PubMed ID: 22402131
    [Abstract] [Full Text] [Related]

  • 4. p53 regulates FAK expression in human tumor cells.
    Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG.
    Mol Carcinog; 2008 May 11; 47(5):373-82. PubMed ID: 17999388
    [Abstract] [Full Text] [Related]

  • 5. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
    Golubovskaya VM, Finch R, Cance WG.
    J Biol Chem; 2005 Jul 01; 280(26):25008-21. PubMed ID: 15855171
    [Abstract] [Full Text] [Related]

  • 6. The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.
    Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG.
    Biochem J; 2008 Apr 01; 411(1):151-60. PubMed ID: 18215142
    [Abstract] [Full Text] [Related]

  • 7. Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.
    Golubovskaya VM, Ho B, Conroy J, Liu S, Wang D, Cance WG.
    Cancers (Basel); 2014 Jan 21; 6(1):166-78. PubMed ID: 24452144
    [Abstract] [Full Text] [Related]

  • 8. Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors.
    Dragoj M, Bankovic J, Sereti E, Stojanov SJ, Dimas K, Pesic M, Stankovic T.
    Invest New Drugs; 2017 Dec 21; 35(6):718-732. PubMed ID: 28733702
    [Abstract] [Full Text] [Related]

  • 9. FAK and p53 protein interactions.
    Golubovskaya VM, Cance WG.
    Anticancer Agents Med Chem; 2011 Sep 21; 11(7):617-9. PubMed ID: 21355845
    [Abstract] [Full Text] [Related]

  • 10. MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.
    Hirai H, Arai T, Okada M, Nishibata T, Kobayashi M, Sakai N, Imagaki K, Ohtani J, Sakai T, Yoshizumi T, Mizuarai S, Iwasawa Y, Kotani H.
    Cancer Biol Ther; 2010 Apr 01; 9(7):514-22. PubMed ID: 20107315
    [Abstract] [Full Text] [Related]

  • 11. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
    Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN.
    Cell Cycle; 2012 Sep 01; 11(17):3250-9. PubMed ID: 22894899
    [Abstract] [Full Text] [Related]

  • 12. p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines.
    Anaganti S, Fernández-Cuesta L, Langerød A, Hainaut P, Olivier M.
    Cancer Lett; 2011 Jan 28; 300(2):215-24. PubMed ID: 21071137
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
    Neuteboom ST, Karjian PL, Boyer CR, Beryt M, Pegram M, Wahl GM, Shepard HM.
    Mol Cancer Ther; 2002 Apr 28; 1(6):377-84. PubMed ID: 12477050
    [Abstract] [Full Text] [Related]

  • 14. Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
    Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, Crudele A, Ceccarelli S, Carcarino E, D'Oria V, Porru M, Giorda E, Ferrari K, Miele L, Villa E, Balsano C, Pasini D, Furlanello C, Locatelli F, Nobili V, Rota R, Leonetti C, Alisi A.
    Cell Death Differ; 2017 May 28; 24(5):889-902. PubMed ID: 28338656
    [Abstract] [Full Text] [Related]

  • 15. Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
    Soares J, Raimundo L, Pereira NA, Monteiro Â, Gomes S, Bessa C, Pereira C, Queiroz G, Bisio A, Fernandes J, Gomes C, Reis F, Gonçalves J, Inga A, Santos MM, Saraiva L.
    Oncotarget; 2016 Jan 26; 7(4):4326-43. PubMed ID: 26735173
    [Abstract] [Full Text] [Related]

  • 16. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism.
    Pereira DM, Simões AE, Gomes SE, Castro RE, Carvalho T, Rodrigues CM, Borralho PM.
    Oncotarget; 2016 Jun 07; 7(23):34322-40. PubMed ID: 27144434
    [Abstract] [Full Text] [Related]

  • 17. The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.
    Golubovskaya VM, Zheng M, Zhang L, Li JL, Cance WG.
    BMC Cancer; 2009 Aug 12; 9():280. PubMed ID: 19671193
    [Abstract] [Full Text] [Related]

  • 18. Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype.
    Zhong B, Shingyoji M, Hanazono M, Nguyễn TT, Morinaga T, Tada Y, Shimada H, Hiroshima K, Tagawa M.
    Apoptosis; 2020 Aug 12; 25(7-8):535-547. PubMed ID: 32468177
    [Abstract] [Full Text] [Related]

  • 19. Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.
    Du T, Qu Y, Li J, Li H, Su L, Zhou Q, Yan M, Li C, Zhu Z, Liu B.
    Mol Cancer; 2014 May 04; 13():100. PubMed ID: 24885567
    [Abstract] [Full Text] [Related]

  • 20. A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.
    Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T.
    Clin Cancer Res; 2009 Jun 01; 15(11):3725-32. PubMed ID: 19458054
    [Abstract] [Full Text] [Related]

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