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2510 related items for PubMed ID: 23872073

  • 1. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
    Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ.
    Cell Signal; 2013 Nov; 25(11):2198-209. PubMed ID: 23872073
    [Abstract] [Full Text] [Related]

  • 2. TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.
    Samarakoon R, Higgins SP, Higgins CE, Higgins PJ.
    J Mol Cell Cardiol; 2008 Mar; 44(3):527-38. PubMed ID: 18255094
    [Abstract] [Full Text] [Related]

  • 3. Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.
    Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ.
    Cell Signal; 2014 Jul; 26(7):1427-36. PubMed ID: 24613410
    [Abstract] [Full Text] [Related]

  • 4. Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses.
    Overstreet JM, Samarakoon R, Cardona-Grau D, Goldschmeding R, Higgins PJ.
    FASEB J; 2015 Apr; 29(4):1258-68. PubMed ID: 25480384
    [Abstract] [Full Text] [Related]

  • 5. Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.
    Samarakoon R, Higgins CE, Higgins SP, Kutz SM, Higgins PJ.
    J Cell Physiol; 2005 Jul; 204(1):236-46. PubMed ID: 15622520
    [Abstract] [Full Text] [Related]

  • 6. Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways.
    Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, Goldschmeding R, Higgins PJ, Samarakoon R.
    FASEB J; 2019 Sep; 33(9):9797-9810. PubMed ID: 31095421
    [Abstract] [Full Text] [Related]

  • 7. Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.
    Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ.
    J Pathol; 2015 Aug; 236(4):421-32. PubMed ID: 25810340
    [Abstract] [Full Text] [Related]

  • 8. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.
    Shimizu H, Yisireyili M, Nishijima F, Niwa T.
    Am J Nephrol; 2013 Aug; 37(2):97-103. PubMed ID: 23363842
    [Abstract] [Full Text] [Related]

  • 9. 4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
    Larroque-Cardoso P, Mucher E, Grazide MH, Josse G, Schmitt AM, Nadal-Wolbold F, Zarkovic K, Salvayre R, Nègre-Salvayre A.
    Free Radic Biol Med; 2014 Jun; 71():427-436. PubMed ID: 24561579
    [Abstract] [Full Text] [Related]

  • 10. Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts.
    Mun JH, Kim YM, Kim BS, Kim JH, Kim MB, Ko HC.
    Wound Repair Regen; 2014 Jun; 22(1):125-33. PubMed ID: 24471776
    [Abstract] [Full Text] [Related]

  • 11. Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.
    Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ.
    PLoS One; 2011 Jun; 6(7):e22896. PubMed ID: 21829547
    [Abstract] [Full Text] [Related]

  • 12. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
    Lee SY, Shin SJ, Kim HS.
    Int J Oncol; 2013 Mar; 42(3):1027-35. PubMed ID: 23314357
    [Abstract] [Full Text] [Related]

  • 13. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3.
    Yang F, Chung AC, Huang XR, Lan HY.
    Hypertension; 2009 Oct; 54(4):877-84. PubMed ID: 19667256
    [Abstract] [Full Text] [Related]

  • 14. Low-dose paclitaxel ameliorates renal fibrosis by suppressing transforming growth factor-β1-induced plasminogen activator inhibitor-1 signaling.
    Jung ES, Lee J, Heo NJ, Kim S, Kim DK, Joo KW, Han JS.
    Nephrology (Carlton); 2016 Jul; 21(7):574-82. PubMed ID: 26869361
    [Abstract] [Full Text] [Related]

  • 15. NADPH oxidase 4 contributes to connective tissue growth factor expression through Smad3-dependent signaling pathway.
    Liu XH, Zhang QY, Pan LL, Liu SY, Xu P, Luo XL, Zou SL, Xin H, Qu LF, Zhu YZ.
    Free Radic Biol Med; 2016 May; 94():174-84. PubMed ID: 26945889
    [Abstract] [Full Text] [Related]

  • 16. The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region.
    Jeon WK, Choi J, Park SJ, Jo EJ, Lee YK, Lim S, Kim JH, Letterio JJ, Liu F, Kim SJ, Kim BC.
    Oncotarget; 2015 Dec 08; 6(39):41650-66. PubMed ID: 26497676
    [Abstract] [Full Text] [Related]

  • 17. TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications.
    Higgins CE, Tang J, Mian BM, Higgins SP, Gifford CC, Conti DJ, Meldrum KK, Samarakoon R, Higgins PJ.
    FASEB J; 2019 Oct 08; 33(10):10596-10606. PubMed ID: 31284746
    [Abstract] [Full Text] [Related]

  • 18. Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells.
    Morales MG, Vazquez Y, Acuña MJ, Rivera JC, Simon F, Salas JD, Alvarez Ruf J, Brandan E, Cabello-Verrugio C.
    Int J Biochem Cell Biol; 2012 Nov 08; 44(11):1993-2002. PubMed ID: 22964022
    [Abstract] [Full Text] [Related]

  • 19. Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.
    Anorga S, Overstreet JM, Falke LL, Tang J, Goldschmeding RG, Higgins PJ, Samarakoon R.
    FASEB J; 2018 May 08; 32(5):2644-2657. PubMed ID: 29298862
    [Abstract] [Full Text] [Related]

  • 20. PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-β1-receptor signaling.
    Gifford CC, Lian F, Tang J, Costello A, Goldschmeding R, Samarakoon R, Higgins PJ.
    FASEB J; 2021 Jul 08; 35(7):e21725. PubMed ID: 34110636
    [Abstract] [Full Text] [Related]

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