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Journal Abstract Search

169 related items for PubMed ID: 23877697

  • 1. Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.
    Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP.
    Antimicrob Agents Chemother; 2013 Oct; 57(10):4882-93. PubMed ID: 23877697
    [Abstract] [Full Text] [Related]

  • 2. Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei.
    Bachmaier S, Gould MK, Polatoglou E, Omelianczyk R, Brennand AE, Aloraini MA, Munday JC, Horn D, Boshart M, de Koning HP.
    Front Cell Infect Microbiol; 2023 Oct; 13():1204707. PubMed ID: 37475965
    [Abstract] [Full Text] [Related]

  • 3. Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
    Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R.
    J Med Chem; 2018 May 10; 61(9):3870-3888. PubMed ID: 29672041
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
    Veerman J, van den Bergh T, Orrling KM, Jansen C, Cos P, Maes L, Chatelain E, Ioset JR, Edink EE, Tenor H, Seebeck T, de Esch I, Leurs R, Sterk GJ.
    Bioorg Med Chem; 2016 Apr 01; 24(7):1573-81. PubMed ID: 26935942
    [Abstract] [Full Text] [Related]

  • 5. Cyclic AMP Regulates Social Behavior in African Trypanosomes.
    Oberholzer M, Saada EA, Hill KL.
    mBio; 2015 Apr 28; 6(3):e01954-14. PubMed ID: 25922395
    [Abstract] [Full Text] [Related]

  • 6. High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes.
    Horn D.
    Parasitology; 2014 Jan 28; 141(1):77-82. PubMed ID: 23561654
    [Abstract] [Full Text] [Related]

  • 7. The N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton.
    Luginbuehl E, Ryter D, Schranz-Zumkehr J, Oberholzer M, Kunz S, Seebeck T.
    Eukaryot Cell; 2010 Oct 28; 9(10):1466-75. PubMed ID: 20693305
    [Abstract] [Full Text] [Related]

  • 8. Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.
    Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, Zorg S, Veerman J, Seebeck T, Sterk GJ, de Esch IJ, Leurs R.
    J Med Chem; 2012 Oct 25; 55(20):8745-56. PubMed ID: 22963052
    [Abstract] [Full Text] [Related]

  • 9. An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.
    de Macêdo JP, Schumann Burkard G, Niemann M, Barrett MP, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P.
    PLoS Pathog; 2015 May 25; 11(5):e1004875. PubMed ID: 25946070
    [Abstract] [Full Text] [Related]

  • 10. The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.
    Oberholzer M, Marti G, Baresic M, Kunz S, Hemphill A, Seebeck T.
    FASEB J; 2007 Mar 25; 21(3):720-31. PubMed ID: 17167070
    [Abstract] [Full Text] [Related]

  • 11. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.
    Mony BM, MacGregor P, Ivens A, Rojas F, Cowton A, Young J, Horn D, Matthews K.
    Nature; 2014 Jan 30; 505(7485):681-685. PubMed ID: 24336212
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).
    Woodring JL, Bland ND, Ochiana SO, Campbell RK, Pollastri MP.
    Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5971-4. PubMed ID: 24042005
    [Abstract] [Full Text] [Related]

  • 13. The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
    Begolo D, Vincent IM, Giordani F, Pöhner I, Witty MJ, Rowan TG, Bengaly Z, Gillingwater K, Freund Y, Wade RC, Barrett MP, Clayton C.
    PLoS Pathog; 2018 Sep 01; 14(9):e1007315. PubMed ID: 30252911
    [Abstract] [Full Text] [Related]

  • 14. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.
    Díaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascón A.
    Biochem J; 2006 Oct 15; 399(2):305-14. PubMed ID: 16776650
    [Abstract] [Full Text] [Related]

  • 15. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.
    Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.
    Proc Natl Acad Sci U S A; 2018 Sep 18; 115(38):9616-9621. PubMed ID: 30185555
    [Abstract] [Full Text] [Related]

  • 16. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.
    de Heuvel E, Singh AK, Edink E, van der Meer T, van der Woude M, Sadek P, Krell-Jørgensen MP, van den Bergh T, Veerman J, Caljon G, Kalejaiye TD, Wijtmans M, Maes L, de Koning HP, Jan Sterk G, Siderius M, de Esch IJP, Brown DG, Leurs R.
    Bioorg Med Chem; 2019 Sep 15; 27(18):3998-4012. PubMed ID: 31327675
    [Abstract] [Full Text] [Related]

  • 17. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
    de Heuvel E, Singh AK, Boronat P, Kooistra AJ, van der Meer T, Sadek P, Blaazer AR, Shaner NC, Bindels DS, Caljon G, Maes L, Sterk GJ, Siderius M, Oberholzer M, de Esch IJP, Brown DG, Leurs R.
    Bioorg Med Chem; 2019 Sep 15; 27(18):4013-4029. PubMed ID: 31378593
    [Abstract] [Full Text] [Related]

  • 18. Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.
    Kalidas S, Cestari I, Monnerat S, Li Q, Regmi S, Hasle N, Labaied M, Parsons M, Stuart K, Phillips MA.
    Eukaryot Cell; 2014 Apr 15; 13(4):504-16. PubMed ID: 24562907
    [Abstract] [Full Text] [Related]

  • 19. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
    Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA.
    Proc Natl Acad Sci U S A; 2006 Dec 12; 103(50):19194-9. PubMed ID: 17142316
    [Abstract] [Full Text] [Related]

  • 20. In silico evolutionary and structural analysis of cAMP response proteins (CARPs) from Leishmania major.
    Bhakta S, Bhattacharya A.
    Arch Microbiol; 2023 Mar 20; 205(4):125. PubMed ID: 36941487
    [Abstract] [Full Text] [Related]

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