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Journal Abstract Search

106 related items for PubMed ID: 23879329

  • 1. Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.
    Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M.
    J Med Chem; 2013 Aug 22; 56(16):6467-77. PubMed ID: 23879329
    [Abstract] [Full Text] [Related]

  • 2. The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.
    Shekh-Ahmad T, Mawasi H, McDonough JH, Yagen B, Bialer M.
    Epilepsy Behav; 2015 Aug 22; 49():298-302. PubMed ID: 25979572
    [Abstract] [Full Text] [Related]

  • 3. Pharmacokinetic-Pharmacodynamic Correlation and Brain Penetration of sec-Butylpropylacetamide, a New CNS Drug Possessing Unique Activity against Status Epilepticus.
    Mawasi H, Bibi D, Shekh-Ahmad T, Shaul C, Blotnik S, Bialer M.
    Mol Pharm; 2016 Jul 05; 13(7):2492-6. PubMed ID: 27218460
    [Abstract] [Full Text] [Related]

  • 4. Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.
    Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M.
    Epilepsia; 2014 Feb 05; 55(2):353-61. PubMed ID: 24313671
    [Abstract] [Full Text] [Related]

  • 5. sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats.
    Bar-Klein G, Swissa E, Kamintsky L, Shekh-Ahmad T, Saar-Ashkenazy R, Hubary Y, Shrot S, Stetlander L, Eisenkraft A, Friedman A, Bialer M.
    Epilepsia; 2014 Dec 05; 55(12):1953-8. PubMed ID: 25377630
    [Abstract] [Full Text] [Related]

  • 6. Evaluation of the antiallodynic, teratogenic and pharmacokinetic profile of stereoisomers of valnoctamide, an amide derivative of a chiral isomer of valproic acid.
    Kaufmann D, Yagen B, Minert A, Wlodarczyk B, Finnell RH, Schurig V, Devor M, Bialer M.
    Neuropharmacology; 2010 Jun 05; 58(8):1228-36. PubMed ID: 20230843
    [Abstract] [Full Text] [Related]

  • 7. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
    White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M.
    Epilepsia; 2012 Jan 05; 53(1):134-46. PubMed ID: 22150444
    [Abstract] [Full Text] [Related]

  • 8. Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
    Shimshoni JA, Yagen B, Wlodarczyk B, Finnell RH, Schurig V, Bialer M.
    Epilepsia; 2010 Mar 05; 51(3):323-32. PubMed ID: 19674061
    [Abstract] [Full Text] [Related]

  • 9. Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide--Amide derivatives of valproic acid.
    Mawasi H, Shekh-Ahmad T, Finnell RH, Wlodarczyk BJ, Bialer M.
    Epilepsy Behav; 2015 May 05; 46():72-8. PubMed ID: 25863940
    [Abstract] [Full Text] [Related]

  • 10. Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.
    Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M.
    Epilepsia; 2014 Dec 05; 55(12):1944-52. PubMed ID: 25442425
    [Abstract] [Full Text] [Related]

  • 11. Pharmacokinetic and pharmacodynamic analysis of (2S,3S)-sec-butylpropylacetamide (SPD) in rats and pigs-A CNS-active stereoisomer of SPD.
    Bibi D, Bialer M.
    Epilepsia; 2020 Jan 05; 61(1):149-156. PubMed ID: 31957880
    [Abstract] [Full Text] [Related]

  • 12. A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.
    Pouliot W, Bialer M, Hen N, Shekh-Ahmad T, Kaufmann D, Yagen B, Ricks K, Roach B, Nelson C, Dudek FE.
    Neuroscience; 2013 Feb 12; 231():145-56. PubMed ID: 23159312
    [Abstract] [Full Text] [Related]

  • 13. Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.
    Shekh-Ahmad T, Hen N, McDonough JH, Yagen B, Bialer M.
    Epilepsia; 2013 Sep 12; 54 Suppl 6(Suppl 6):99-102. PubMed ID: 24001086
    [Abstract] [Full Text] [Related]

  • 14. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.
    Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M.
    Pharm Res; 2003 Aug 12; 20(8):1293-301. PubMed ID: 12948028
    [Abstract] [Full Text] [Related]

  • 15. Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.
    Haines KM, Matson LM, Dunn EN, Ardinger CE, Lee-Stubbs R, Bibi D, McDonough JH, Bialer M.
    Epilepsia; 2019 Feb 12; 60(2):315-321. PubMed ID: 30615805
    [Abstract] [Full Text] [Related]

  • 16. Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
    Okada A, Noyori H, Yagen B, Shimshoni JA, Bialer M, Fujiwara M.
    Birth Defects Res B Dev Reprod Toxicol; 2009 Oct 12; 86(5):394-401. PubMed ID: 19830722
    [Abstract] [Full Text] [Related]

  • 17. Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
    Mareš P, Kubová H, Hen N, Yagen B, Bialer M.
    Epilepsy Res; 2013 Sep 12; 106(1-2):64-73. PubMed ID: 23815889
    [Abstract] [Full Text] [Related]

  • 18. Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid.
    Spiegelstein O, Yagen B, Levy RH, Finnell RH, Bennett GD, Roeder M, Schurig V, Bialer M.
    Pharm Res; 1999 Oct 12; 16(10):1582-8. PubMed ID: 10554101
    [Abstract] [Full Text] [Related]

  • 19. Pharmacokinetic and pharmacodynamic analysis of (E)-2-ene valproyl derivatives of glycine and valproyl derivatives of nipecotic acid.
    Bialer M, Kadry B, Abdul-Hai A, Haj-Yehia A, Sterling J, Herzig Y, Shirvan M.
    Biopharm Drug Dispos; 1996 Oct 12; 17(7):565-75. PubMed ID: 8894115
    [Abstract] [Full Text] [Related]

  • 20. Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
    Pessah N, Kaufmann D, Yagen B, Hen N, Wlodarczyk B, Finnell RH, Bialer M.
    Epilepsia; 2010 Oct 12; 51(10):1944-53. PubMed ID: 20738383
    [Abstract] [Full Text] [Related]

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