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Journal Abstract Search

168 related items for PubMed ID: 23900402

  • 21. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
    Cui H, Kamal Z, Ai T, Xu Y, More SS, Wilson DJ, Chen L.
    J Med Chem; 2014 Oct 23; 57(20):8340-57. PubMed ID: 25275824
    [Abstract] [Full Text] [Related]

  • 22. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
    Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB.
    Eur J Med Chem; 2018 Jul 15; 155():806-823. PubMed ID: 29957526
    [Abstract] [Full Text] [Related]

  • 23. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
    Yang L, Ma X, Yuan C, He Y, Li L, Fang S, Xia W, He T, Qian S, Xu Z, Li G, Wang Z.
    Eur J Med Chem; 2017 Jul 07; 134():230-241. PubMed ID: 28415012
    [Abstract] [Full Text] [Related]

  • 24. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
    Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A.
    Cancer Res; 2006 Apr 15; 66(8):4368-77. PubMed ID: 16618762
    [Abstract] [Full Text] [Related]

  • 25. Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
    Manjula R, Gokhale N, Unni S, Deshmukh P, Reddyrajula R, Srinivas Bharath MM, Dalimba U, Padmanabhan B.
    Bioorg Chem; 2019 Nov 15; 92():103281. PubMed ID: 31561106
    [Abstract] [Full Text] [Related]

  • 26. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
    Chowdhury S, Sripathy S, Webster A, Park A, Lao U, Hsu JH, Loe T, Bedalov A, Simon JA.
    Molecules; 2020 Jan 21; 25(3):. PubMed ID: 31973227
    [Abstract] [Full Text] [Related]

  • 27. Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.
    Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K.
    Mol Biosyst; 2011 Jan 21; 7(1):59-66. PubMed ID: 20931131
    [Abstract] [Full Text] [Related]

  • 28. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
    Galli U, Mesenzani O, Coppo C, Sorba G, Canonico PL, Tron GC, Genazzani AA.
    Eur J Med Chem; 2012 Sep 21; 55():58-66. PubMed ID: 22835719
    [Abstract] [Full Text] [Related]

  • 29. Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.
    Rotili D, Carafa V, Tarantino D, Botta G, Nebbioso A, Altucci L, Mai A.
    Bioorg Med Chem; 2011 Jun 15; 19(12):3659-68. PubMed ID: 21306905
    [Abstract] [Full Text] [Related]

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  • 31. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
    Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam EW, Fuchter MJ.
    ChemMedChem; 2015 Jan 15; 10(1):69-82. PubMed ID: 25395356
    [Abstract] [Full Text] [Related]

  • 32. Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.
    Arab Sadeghabadi Z, Nourbakhsh M, Pasalar P, Emamgholipour S, Golestani A, Larijani B, Razzaghy-Azar M.
    Obes Res Clin Pract; 2018 Jan 15; 12(2):167-173. PubMed ID: 29150224
    [Abstract] [Full Text] [Related]

  • 33. Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
    Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D, D'Orazi G.
    Free Radic Biol Med; 2010 May 15; 48(10):1338-46. PubMed ID: 20171273
    [Abstract] [Full Text] [Related]

  • 34. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
    Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB.
    Eur J Med Chem; 2014 Apr 09; 76():414-26. PubMed ID: 24602787
    [Abstract] [Full Text] [Related]

  • 35. Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1-3 Inhibitors.
    Hong JY, Fernandez I, Anmangandla A, Lu X, Bai JJ, Lin H.
    ACS Chem Biol; 2021 Jul 16; 16(7):1266-1275. PubMed ID: 34139124
    [Abstract] [Full Text] [Related]

  • 36. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
    Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacché N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D.
    J Med Chem; 2017 Mar 23; 60(6):2344-2360. PubMed ID: 28240897
    [Abstract] [Full Text] [Related]

  • 37. SIRT1 decelerates morphological processing of oligodendrocyte cell lines and regulates the expression of cytoskeleton-related oligodendrocyte proteins.
    Hisahara S, Iwahara N, Matsushita T, Suzuki S, Matsumura A, Fujikura M, Yokokawa K, Saito T, Manabe T, Kawamata J, Horio Y, Shimohama S.
    Biochem Biophys Res Commun; 2021 Mar 26; 546():7-14. PubMed ID: 33556638
    [Abstract] [Full Text] [Related]

  • 38. The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition.
    Schnekenburger M, Mathieu V, Lefranc F, Jang JY, Masi M, Kijjoa A, Evidente A, Kim HJ, Kiss R, Dicato M, Han BW, Diederich M.
    Molecules; 2018 Feb 05; 23(2):. PubMed ID: 29401749
    [Abstract] [Full Text] [Related]

  • 39. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
    Shah AA, Ito A, Nakata A, Yoshida M.
    Biol Pharm Bull; 2016 Feb 05; 39(10):1739-1742. PubMed ID: 27725455
    [Abstract] [Full Text] [Related]

  • 40. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
    Kalle AM, Mallika A, Badiger J, Alinakhi, Talukdar P, Sachchidanand.
    Biochem Biophys Res Commun; 2010 Oct 08; 401(1):13-9. PubMed ID: 20813094
    [Abstract] [Full Text] [Related]

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